登録情報 データベース : PDB / ID : 6cbx 構造の表示 ダウンロードとリンクタイトル Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 要素N-lysine methyltransferase SMYD2 詳細 キーワード TRANSFERASE/INHIBITOR / SMYD2 MTF9975 inhibitor / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding ... lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / regulation of signal transduction by p53 class mediator / Regulation of TP53 Activity through Methylation / PKMTs methylate histone lysines / p53 binding / heart development / negative regulation of cell population proliferation / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytosol / cytoplasm 類似検索 - 分子機能 SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain ... SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Beta Complex / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.94 Å 詳細データ登録者 ZENG, H. / DONG, A. / Hutchinson, A. / Seitova, A. / TATLOCK, J. / KUMPF, R. / OWEN, A. / TAYLOR, A. / Casimiro-Garcia, A. / Bountra, C. ...ZENG, H. / DONG, A. / Hutchinson, A. / Seitova, A. / TATLOCK, J. / KUMPF, R. / OWEN, A. / TAYLOR, A. / Casimiro-Garcia, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / BROWN, P.J. / WU, H. / Structural Genomics Consortium (SGC) 引用ジャーナル : to be published タイトル : Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497著者: ZENG, H. / DONG, A. / Hutchinson, A. / Seitova, A. / TATLOCK, J. / KUMPF, R. / OWEN, A. / TAYLOR, A. / Casimiro-Garcia, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / BROWN, P.J. / WU, ... 著者 : ZENG, H. / DONG, A. / Hutchinson, A. / Seitova, A. / TATLOCK, J. / KUMPF, R. / OWEN, A. / TAYLOR, A. / Casimiro-Garcia, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / BROWN, P.J. / WU, H. / Structural Genomics Consortium (SGC) 履歴 登録 2018年2月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2018年3月14日 Provider : repository / タイプ : Initial release改定 1.1 2024年3月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name
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