Entry Database : PDB / ID : 6c56 Structure visualization Downloads & linksTitle Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in its Apo form ComponentsGeranylgeranyl pyrophosphate synthase Details Keywords TRANSFERASE / ISOPRENOID PATHWAY / ISOPENTENYL TRANSFERASEFunction / homology Function and homology informationFunction Domain/homology Component
isoprenoid metabolic process / plastoquinone biosynthetic process / geranylgeranyl diphosphate biosynthetic process / geranylgeranyl diphosphate synthase / transferase complex / Transferases; Transferring alkyl or aryl groups, other than methyl groups / geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / prenyltransferase activity ... isoprenoid metabolic process / plastoquinone biosynthetic process / geranylgeranyl diphosphate biosynthetic process / geranylgeranyl diphosphate synthase / transferase complex / Transferases; Transferring alkyl or aryl groups, other than methyl groups / geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / prenyltransferase activity / Cholesterol biosynthesis / farnesyltranstransferase activity / ubiquinone biosynthetic process / isoprenoid biosynthetic process / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / Activation of gene expression by SREBF (SREBP) / Z disc / perinuclear region of cytoplasm / mitochondrion / nucleoplasm / identical protein binding / metal ion binding / cytoplasm / cytosol Similarity search - Function Polyprenyl synthases signature 1. / Polyprenyl synthases signature 2. / Polyprenyl synthetase, conserved site / Polyprenyl synthetase / Polyprenyl synthetase / Farnesyl Diphosphate Synthase / Farnesyl Diphosphate Synthase / Isoprenoid synthase domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Park, J. / Ta, V. / Tsantrizos, Y.S. / Berghuis, A.M. CitationJournal : J. Med. Chem. / Year : 2018Title : Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.Authors : Lacbay, C.M. / Waller, D.D. / Park, J. / Gomez Palou, M. / Vincent, F. / Huang, X.F. / Ta, V. / Berghuis, A.M. / Sebag, M. / Tsantrizos, Y.S. History Deposition Jan 15, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 5, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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