登録情報 | データベース: PDB / ID: 6b2p |
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タイトル | Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis |
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要素 | Serine/threonine-protein kinase PknB |
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キーワード | TRANSFERASE/INHIBITOR / kinase / drug design / tuberculosis / TRANSFERASE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
negative regulation of growth rate / protein serine/threonine kinase activity => GO:0004674 / acetyltransferase activator activity / negative regulation of catalytic activity / negative regulation of fatty acid biosynthetic process / response to host immune response / positive regulation of catalytic activity / positive regulation of DNA binding / peptidoglycan biosynthetic process / peptidoglycan-based cell wall ...negative regulation of growth rate / protein serine/threonine kinase activity => GO:0004674 / acetyltransferase activator activity / negative regulation of catalytic activity / negative regulation of fatty acid biosynthetic process / response to host immune response / positive regulation of catalytic activity / positive regulation of DNA binding / peptidoglycan biosynthetic process / peptidoglycan-based cell wall / negative regulation of protein binding / manganese ion binding / regulation of cell shape / protein autophosphorylation / membrane => GO:0016020 / non-specific serine/threonine protein kinase / protein kinase activity / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / identical protein binding / metal ion binding / plasma membrane類似検索 - 分子機能 PASTA domain / PASTA domain / PASTA domain profile. / PASTA / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ...PASTA domain / PASTA domain / PASTA domain profile. / PASTA / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-CJJ / Serine/threonine-protein kinase PknB / Serine/threonine-protein kinase PknB類似検索 - 構成要素 |
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生物種 | Mycobacterium tuberculosis (結核菌) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 3.01 Å |
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データ登録者 | Zuccola, H.J. |
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引用 | ジャーナル: ACS Med Chem Lett / 年: 2017 タイトル: Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. 著者: Wang, T. / Bemis, G. / Hanzelka, B. / Zuccola, H. / Wynn, M. / Moody, C.S. / Green, J. / Locher, C. / Liu, A. / Gao, H. / Xu, Y. / Wang, S. / Wang, J. / Bennani, Y.L. / Thomson, J.A. / Muh, U. |
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履歴 | 登録 | 2017年9月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年2月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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