登録情報 | データベース: PDB / ID: 6ash |
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タイトル | Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution |
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要素 | Cathepsin K |
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キーワード | HYDROLASE/ HYDROLASE Inhibitor / cathepsin K / exosite / inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE / HYDROLASE- HYDROLASE Inhibitor complex |
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機能・相同性 | 機能・相同性情報
cathepsin K / mononuclear cell differentiation / intramembranous ossification / negative regulation of cartilage development / cellular response to zinc ion starvation / RUNX1 regulates transcription of genes involved in differentiation of keratinocytes / thyroid hormone generation / endolysosome lumen / Trafficking and processing of endosomal TLR / proteoglycan binding ...cathepsin K / mononuclear cell differentiation / intramembranous ossification / negative regulation of cartilage development / cellular response to zinc ion starvation / RUNX1 regulates transcription of genes involved in differentiation of keratinocytes / thyroid hormone generation / endolysosome lumen / Trafficking and processing of endosomal TLR / proteoglycan binding / Activation of Matrix Metalloproteinases / cysteine-type endopeptidase activator activity involved in apoptotic process / mitophagy / fibronectin binding / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / cysteine-type peptidase activity / bone resorption / cellular response to transforming growth factor beta stimulus / collagen binding / MHC class II antigen presentation / Degradation of the extracellular matrix / lysosomal lumen / proteolysis involved in protein catabolic process / positive regulation of apoptotic signaling pathway / response to insulin / response to organic cyclic compound / cellular response to tumor necrosis factor / response to ethanol / lysosome / immune response / apical plasma membrane / external side of plasma membrane / cysteine-type endopeptidase activity / intracellular membrane-bounded organelle / serine-type endopeptidase activity / proteolysis / extracellular space / extracellular region / nucleoplasm類似検索 - 分子機能 Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Papain-like cysteine endopeptidase / : / Cysteine peptidase, asparagine active site / Eukaryotic thiol (cysteine) proteases asparagine active site. / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / Peptidase C1A, papain C-terminal ...Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Papain-like cysteine endopeptidase / : / Cysteine peptidase, asparagine active site / Eukaryotic thiol (cysteine) proteases asparagine active site. / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / Papain-like cysteine peptidase superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid / Cathepsin K類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.423 Å |
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データ登録者 | Law, S. / Aguda, A. / Nguyen, N. / Brayer, G. / Bromme, D. |
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資金援助 | カナダ, 4件 組織 | 認可番号 | 国 |
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Canadian Institutes of Health Research (CIHR) | MOP-89974 | カナダ | Canadian Institutes of Health Research (CIHR) | MOP-125866 | カナダ | Canadian Institutes of Health Research (CIHR) | MOP-125866 | カナダ | Natural Sciences and Engineering Research Council (NSERC, Canada) | RGPIN-326803-13 | カナダ |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution. 著者: Law, S. / Brayer, G. / Bromme, D. |
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履歴 | 登録 | 2017年8月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年8月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月21日 | Group: Data collection / Database references / Structure summary カテゴリ: citation / struct / Item: _citation.title / _struct.title |
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改定 1.2 | 2020年1月8日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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