Entry Database : PDB / ID : 6ae8 Structure visualization Downloads & linksTitle Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement ComponentsHistone H2A.Z-specific chaperone CHZ1 Histone H2B.1,Histone H2A.Z DetailsKeywords CHAPERONE / histone variantsFunction / homology Function and homology informationFunction Domain/homology Component
HATs acetylate histones / nuclear-transcribed mRNA catabolic process, non-stop decay / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Assembly of the ORC complex at the origin of replication / HDACs deacetylate histones / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / replication fork protection complex / Oxidative Stress Induced Senescence ... HATs acetylate histones / nuclear-transcribed mRNA catabolic process, non-stop decay / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Assembly of the ORC complex at the origin of replication / HDACs deacetylate histones / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / replication fork protection complex / Oxidative Stress Induced Senescence / postreplication repair / silent mating-type cassette heterochromatin formation / RNA Polymerase I Promoter Escape / Estrogen-dependent gene expression / Ub-specific processing proteases / heterochromatin organization / nucleosomal DNA binding / euchromatin / chromatin DNA binding / structural constituent of chromatin / nucleosome / chromatin organization / chromatin remodeling / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin binding / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / DNA binding / identical protein binding / nucleus Similarity search - Function Histone chaperone domain CHZ / Histone chaperone domain CHZ / Histone chaperone domain CHZ / Histone, subunit A / Histone, subunit A / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A conserved site / Histone H2A signature. ... Histone chaperone domain CHZ / Histone chaperone domain CHZ / Histone chaperone domain CHZ / Histone, subunit A / Histone, subunit A / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A conserved site / Histone H2A signature. / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone H2A / Histone 2A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Saccharomyces cerevisiae S288c (yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.65 Å DetailsAuthors Wang, Y.Y. / Shan, S. / Zhou, Z. Funding support China, 2items Details Hide detailsOrganization Grant number Country Ministry of Science and Technology (China) 2015CB856200 China Ministry of Science and Technology (China) 31521002 China
CitationJournal : Plos Biol. / Year : 2019Title : Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.Authors : Wang, Y. / Liu, S. / Sun, L. / Xu, N. / Shan, S. / Wu, F. / Liang, X. / Huang, Y. / Luk, E. / Wu, C. / Zhou, Z. History Deposition Aug 3, 2018 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Apr 17, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jun 19, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 22, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_validate_symm_contact / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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