登録情報 | データベース: PDB / ID: 6a30 |
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タイトル | Crystal Structure of Munc13-1 MUN Domain and Synaptobrevin-2 Juxtamembrane Linker Region |
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要素 | - Protein unc-13 homolog A
- Synaptobrevin-2 juxtamembrane linker peptide
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キーワード | EXOCYTOSIS / Synaptic exocytosis / Membrane fusion / Munc13 / Munc18 / SNARE / Synaptobrevin |
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機能・相同性 | 機能・相同性情報
dense core granule priming / neuronal dense core vesicle exocytosis / trans-Golgi Network Vesicle Budding / regulation of delayed rectifier potassium channel activity / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Other interleukin signaling / diacylglycerol binding / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ...dense core granule priming / neuronal dense core vesicle exocytosis / trans-Golgi Network Vesicle Budding / regulation of delayed rectifier potassium channel activity / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Other interleukin signaling / diacylglycerol binding / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Lysosome Vesicle Biogenesis / regulation of synaptic vesicle priming / Glutamate Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / zymogen granule membrane / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / Dopamine Neurotransmitter Release Cycle / Golgi Associated Vesicle Biogenesis / regulated exocytosis / presynaptic dense core vesicle exocytosis / synaptic vesicle docking / storage vacuole / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / positive regulation of glutamate receptor signaling pathway / synaptic vesicle maturation / eosinophil degranulation / vesicle fusion / SNARE complex / SNAP receptor activity / presynaptic active zone cytoplasmic component / Cargo recognition for clathrin-mediated endocytosis / positive regulation of synaptic plasticity / regulation of vesicle-mediated transport / Clathrin-mediated endocytosis / hormone secretion / calcium-ion regulated exocytosis / positive regulation of intracellular protein transport / innervation / positive regulation of dendrite extension / Golgi to plasma membrane protein transport / regulation of exocytosis / neurotransmitter secretion / regulation of short-term neuronal synaptic plasticity / neuron projection terminus / regulation of synaptic vesicle recycling / regulation of amyloid precursor protein catabolic process / syntaxin-1 binding / SNARE complex assembly / positive regulation of neurotransmitter secretion / syntaxin binding / clathrin-coated vesicle / synaptic vesicle priming / Golgi-associated vesicle / neuromuscular junction development / spectrin binding / myosin binding / presynaptic active zone / synaptic vesicle exocytosis / calyx of Held / excitatory synapse / synaptic vesicle endocytosis / amyloid-beta metabolic process / response to glucose / vesicle-mediated transport / SNARE binding / synaptic membrane / secretory granule / synaptic transmission, glutamatergic / establishment of localization in cell / long-term synaptic potentiation / cytoplasmic vesicle membrane / neuromuscular junction / trans-Golgi network / terminal bouton / phospholipid binding / synaptic vesicle membrane / cellular response to insulin stimulus / calcium-dependent protein binding / synaptic vesicle / presynapse / presynaptic membrane / cytoplasmic vesicle / protein-containing complex assembly / vesicle / transmembrane transporter binding / molecular adaptor activity / membrane fusion / cell differentiation / calmodulin binding / protein domain specific binding / axon / glutamatergic synapse / lipid binding / synapse / calcium ion binding / protein-containing complex binding / perinuclear region of cytoplasm / protein-containing complex類似検索 - 分子機能 Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. / Domain of Unknown Function (DUF1041) / Synaptobrevin/Vesicle-associated membrane protein ...Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. / Domain of Unknown Function (DUF1041) / Synaptobrevin/Vesicle-associated membrane protein / Synaptobrevin signature. / Synaptobrevin-like / Synaptobrevin / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / C2 domain superfamily類似検索 - ドメイン・相同性 Vesicle-associated membrane protein 2 / Protein unc-13 homolog A類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.793 Å |
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データ登録者 | Wang, S. / Li, Y. / Gong, J.H. / Ye, S. / Yang, X.F. / Zhang, R.G. / Ma, C. |
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資金援助 | 中国, 4件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China | 31670846 | 中国 | National Natural Science Foundation of China | 31670850 | 中国 | National Natural Science Foundation of China | 31721002 | 中国 | National Basic Research Program of China (973 Program) | 2015CB910800 | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly. 著者: Wang, S. / Li, Y. / Gong, J.H. / Ye, S. / Yang, X.F. / Zhang, R.G. / Ma, C. |
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履歴 | 登録 | 2018年6月14日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年1月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月22日 | Group: Author supporting evidence / Data collection ...Author supporting evidence / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_audit_support / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization |
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