Entry Database : PDB / ID : 6a30 Structure visualization Downloads & linksTitle Crystal Structure of Munc13-1 MUN Domain and Synaptobrevin-2 Juxtamembrane Linker Region ComponentsProtein unc-13 homolog A Synaptobrevin-2 juxtamembrane linker peptide DetailsKeywords EXOCYTOSIS / Synaptic exocytosis / Membrane fusion / Munc13 / Munc18 / SNARE / SynaptobrevinFunction / homology Function and homology informationFunction Domain/homology Component
dense core granule priming / neuronal dense core vesicle exocytosis / trans-Golgi Network Vesicle Budding / regulation of delayed rectifier potassium channel activity / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Other interleukin signaling / diacylglycerol binding / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ... dense core granule priming / neuronal dense core vesicle exocytosis / trans-Golgi Network Vesicle Budding / regulation of delayed rectifier potassium channel activity / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Other interleukin signaling / diacylglycerol binding / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Lysosome Vesicle Biogenesis / Glutamate Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / zymogen granule membrane / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / regulation of synaptic vesicle priming / Dopamine Neurotransmitter Release Cycle / Golgi Associated Vesicle Biogenesis / regulated exocytosis / presynaptic dense core vesicle exocytosis / synaptic vesicle docking / storage vacuole / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / vesicle fusion / positive regulation of glutamate receptor signaling pathway / synaptic vesicle maturation / eosinophil degranulation / SNARE complex / SNAP receptor activity / presynaptic active zone cytoplasmic component / Cargo recognition for clathrin-mediated endocytosis / regulation of vesicle-mediated transport / positive regulation of synaptic plasticity / Clathrin-mediated endocytosis / regulation of exocytosis / hormone secretion / calcium-ion regulated exocytosis / positive regulation of intracellular protein transport / positive regulation of dendrite extension / innervation / Golgi to plasma membrane protein transport / neurotransmitter secretion / regulation of short-term neuronal synaptic plasticity / neuron projection terminus / regulation of synaptic vesicle recycling / regulation of amyloid precursor protein catabolic process / syntaxin binding / syntaxin-1 binding / SNARE complex assembly / positive regulation of neurotransmitter secretion / clathrin-coated vesicle / synaptic vesicle priming / Golgi-associated vesicle / postsynaptic cytosol / spectrin binding / neuromuscular junction development / myosin binding / presynaptic active zone / synaptic vesicle exocytosis / calyx of Held / synaptic vesicle endocytosis / excitatory synapse / amyloid-beta metabolic process / response to glucose / vesicle-mediated transport / SNARE binding / secretory granule / synaptic membrane / synaptic transmission, glutamatergic / establishment of localization in cell / long-term synaptic potentiation / trans-Golgi network / cytoplasmic vesicle membrane / neuromuscular junction / terminal bouton / phospholipid binding / synaptic vesicle membrane / cellular response to insulin stimulus / calcium-dependent protein binding / synaptic vesicle / presynapse / presynaptic membrane / cytoplasmic vesicle / protein-containing complex assembly / vesicle / transmembrane transporter binding / molecular adaptor activity / membrane fusion / postsynaptic density / cell differentiation / calmodulin binding / protein domain specific binding / axon / lipid binding / glutamatergic synapse / synapse / calcium ion binding / protein-containing complex binding Similarity search - Function Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. / Domain of Unknown Function (DUF1041) / Synaptobrevin/Vesicle-associated membrane protein ... Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. / Domain of Unknown Function (DUF1041) / Synaptobrevin/Vesicle-associated membrane protein / Synaptobrevin signature. / Synaptobrevin-like / Synaptobrevin / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / C2 domain superfamily Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.793 Å DetailsAuthors Wang, S. / Li, Y. / Gong, J.H. / Ye, S. / Yang, X.F. / Zhang, R.G. / Ma, C. Funding support China, 4items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31670846 China National Natural Science Foundation of China 31670850 China National Natural Science Foundation of China 31721002 China National Basic Research Program of China (973 Program) 2015CB910800 China
CitationJournal : Nat Commun / Year : 2019Title : Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.Authors : Wang, S. / Li, Y. / Gong, J.H. / Ye, S. / Yang, X.F. / Zhang, R.G. / Ma, C. History Deposition Jun 14, 2018 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 30, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2023 Group : Author supporting evidence / Data collection ... Author supporting evidence / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_audit_support / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization
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