Entry Database : PDB / ID : 5yqz Structure visualization Downloads & linksTitle Structure of the glucagon receptor in complex with a glucagon analogue ComponentsGlucagon analogue Glucagon receptor,Endolysin,Glucagon receptor DetailsKeywords SIGNALING PROTEIN/HYDROLASE / Human GCGR receptor / Class B / 7TM domain / membrane / LCP / XFEL / SIGNALING PROTEIN / SIGNALING PROTEIN-HYDROLASE complexFunction / homology Function and homology informationFunction Domain/homology Component
glucagon receptor binding / regulation of glycogen metabolic process / glucagon receptor activity / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / cellular response to glucagon stimulus / response to starvation / exocytosis / positive regulation of insulin secretion involved in cellular response to glucose stimulus ... glucagon receptor binding / regulation of glycogen metabolic process / glucagon receptor activity / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / cellular response to glucagon stimulus / response to starvation / exocytosis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / peptide hormone binding / regulation of insulin secretion / Synthesis, secretion, and deacylation of Ghrelin / generation of precursor metabolites and energy / hormone-mediated signaling pathway / response to nutrient / viral release from host cell by cytolysis / positive regulation of gluconeogenesis / protein kinase A signaling / cellular response to starvation / peptidoglycan catabolic process / guanyl-nucleotide exchange factor activity / positive regulation of peptidyl-threonine phosphorylation / response to activity / gluconeogenesis / regulation of blood pressure / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / Glucagon signaling in metabolic regulation / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Glucagon-type ligand receptors / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / positive regulation of peptidyl-serine phosphorylation / cell wall macromolecule catabolic process / glucose homeostasis / lysozyme / lysozyme activity / G alpha (s) signalling events / G alpha (q) signalling events / secretory granule lumen / host cell cytoplasm / positive regulation of ERK1 and ERK2 cascade / endosome / cell surface receptor signaling pathway / defense response to bacterium / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / signaling receptor binding / positive regulation of gene expression / negative regulation of apoptotic process / extracellular space / extracellular region / identical protein binding / membrane / plasma membrane Similarity search - Function GPCR, family 2, glucagon receptor / Glucagon / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ... GPCR, family 2, glucagon receptor / Glucagon / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Lysozyme-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human) Enterobacteria phage T4 (virus)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Zhang, H. / Qiao, A. / Yang, L. / VAN EPS, N. / Frederiksen, K. / Yang, D. / Dai, A. / Cai, X. / Zhang, H. / Yi, C. ...Zhang, H. / Qiao, A. / Yang, L. / VAN EPS, N. / Frederiksen, K. / Yang, D. / Dai, A. / Cai, X. / Zhang, H. / Yi, C. / Can, C. / He, L. / Yang, H. / Lau, J. / Ernst, O. / Hanson, M. / Stevens, R. / Wang, M. / Seedtz-Runge, S. / Jiang, H. / Zhao, Q. / Wu, B. Funding support China, 2items Details Hide detailsOrganization Grant number Country National Science Foundation (China) 31422017 China National Science Foundation (China) 81525024 China
CitationJournal : Nature / Year : 2018Title : Structure of the glucagon receptor in complex with a glucagon analogue.Authors: Zhang, H. / Qiao, A. / Yang, L. / Van Eps, N. / Frederiksen, K.S. / Yang, D. / Dai, A. / Cai, X. / Zhang, H. / Yi, C. / Cao, C. / He, L. / Yang, H. / Lau, J. / Ernst, O.P. / Hanson, M.A. / ... Authors : Zhang, H. / Qiao, A. / Yang, L. / Van Eps, N. / Frederiksen, K.S. / Yang, D. / Dai, A. / Cai, X. / Zhang, H. / Yi, C. / Cao, C. / He, L. / Yang, H. / Lau, J. / Ernst, O.P. / Hanson, M.A. / Stevens, R.C. / Wang, M.W. / Reedtz-Runge, S. / Jiang, H. / Zhao, Q. / Wu, B. History Deposition Nov 8, 2017 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 17, 2018 Provider : repository / Type : Initial releaseRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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