Entry Database : PDB / ID : 5yqg Structure visualization Downloads & linksTitle The structure of 14-3-3 and pNumb peptide Components14-3-3 protein eta Peptide from Protein numb homolog DetailsKeywords PEPTIDE BINDING PROTEIN / Complex / Phosphorylation / non-canonicalFunction / homology Function and homology informationFunction Domain/homology Component
neuroblast division in subventricular zone / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / RHO GTPases activate PKNs / Activation of BAD and translocation to mitochondria / glucocorticoid catabolic process / TP53 Regulates Metabolic Genes / regulation of postsynapse assembly / lateral ventricle development / Degradation of GLI1 by the proteasome / negative regulation of dendrite morphogenesis ... neuroblast division in subventricular zone / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / RHO GTPases activate PKNs / Activation of BAD and translocation to mitochondria / glucocorticoid catabolic process / TP53 Regulates Metabolic Genes / regulation of postsynapse assembly / lateral ventricle development / Degradation of GLI1 by the proteasome / negative regulation of dendrite morphogenesis / Hedgehog 'on' state / nuclear receptor-mediated glucocorticoid signaling pathway / Recycling pathway of L1 / regulation of sodium ion transmembrane transporter activity / nuclear glucocorticoid receptor binding / alpha-catenin binding / membrane depolarization during action potential / regulation of postsynaptic neurotransmitter receptor internalization / adherens junction organization / negative regulation of protein localization to plasma membrane / positive regulation of dendrite morphogenesis / clathrin-coated vesicle / regulation of neuron differentiation / positive regulation of neurogenesis / regulation of mitotic nuclear division / intercalated disc / neuroblast proliferation / sodium channel regulator activity / regulation of sodium ion transport / clathrin-coated pit / forebrain development / cytoskeleton organization / axonogenesis / intracellular protein transport / beta-catenin binding / apical part of cell / nervous system development / actin binding / basolateral plasma membrane / cytoplasmic vesicle / transmembrane transporter binding / dendritic spine / endosome membrane / postsynaptic density / early endosome / positive regulation of cell migration / cadherin binding / protein domain specific binding / protein heterodimerization activity / glutamatergic synapse / synapse / positive regulation of DNA-templated transcription / negative regulation of apoptotic process / enzyme binding / identical protein binding / plasma membrane / cytoplasm / cytosol Similarity search - Function NUMB domain / Numb/numb-like / NUMB domain / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. ... NUMB domain / Numb/numb-like / NUMB domain / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / PH-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Chen, X. / Liu, Z. / Wen, W. Funding support China, 3items Details Hide detailsOrganization Grant number Country Ministry of Science and Technology of the People's Republic of China 2014CB910201 China the National Natural Science Foundation of China 31422015, 31670730, 31270778 China the Shanghai Municipal Education Commission 14SG06 China
CitationJournal : J. Biol. Chem. / Year : 2018Title : Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex.Authors : Chen, X. / Liu, Z. / Shan, Z. / Yao, W. / Gu, A. / Wen, W. History Deposition Nov 6, 2017 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 7, 2018 Provider : repository / Type : Initial releaseRevision 1.1 May 2, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_abbrev / _citation.journal_volume ... _citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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