登録情報 | データベース: PDB / ID: 5yi4 |
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タイトル | Solution Structure of the DISC1/Ndel1 complex |
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要素 | Disrupted in schizophrenia 1 homolog,Nuclear distribution protein nudE-like 1 |
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キーワード | PROTEIN BINDING / DISC1 / Ndel1 / coiled coil / psychiatric disorder |
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機能・相同性 | 機能・相同性情報
neurofilament cytoskeleton / pyramidal neuron migration to cerebral cortex / cerebral cortex radially oriented cell migration / establishment of chromosome localization / central nervous system neuron axonogenesis / radial glia-guided pyramidal neuron migration / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain ...neurofilament cytoskeleton / pyramidal neuron migration to cerebral cortex / cerebral cortex radially oriented cell migration / establishment of chromosome localization / central nervous system neuron axonogenesis / radial glia-guided pyramidal neuron migration / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain / oligopeptidase activity / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / regulation of dendritic spine development / nuclear membrane disassembly / RHO GTPases Activate Formins / Separation of Sister Chromatids / vesicle transport along microtubule / neurofilament cytoskeleton organization / lysosome localization / dynein complex / microtubule nucleation / regulation of synapse maturation / axon hillock / positive regulation of ubiquitin-dependent protein catabolic process / non-motile cilium assembly / retrograde axonal transport / activation of GTPase activity / positive regulation of ruffle assembly / mitotic centrosome separation / protein localization to centrosome / microtubule organizing center / microtubule associated complex / intermediate filament cytoskeleton / centrosome localization / inner cell mass cell proliferation / positive regulation of cell-matrix adhesion / regulation of postsynapse organization / neuron projection extension / ciliary base / kinesin complex / positive regulation of neuroblast proliferation / positive regulation of axon regeneration / regulation of intracellular protein transport / regulation of neuron projection development / beta-tubulin binding / cell leading edge / establishment of mitotic spindle orientation / kinesin binding / positive regulation of Wnt signaling pathway / cilium assembly / alpha-tubulin binding / TOR signaling / canonical Wnt signaling pathway / GABA-ergic synapse / positive regulation of axon extension / response to electrical stimulus / axon cytoplasm / regulation of synaptic transmission, glutamatergic / ciliary basal body / positive regulation of GTPase activity / negative regulation of protein binding / chromosome segregation / neuron migration / kinetochore / positive regulation of neuron projection development / microtubule cytoskeleton organization / spindle / neuron cellular homeostasis / neuron projection development / protein localization / cell migration / synaptic vesicle / insulin receptor signaling pathway / nuclear envelope / presynapse / nervous system development / cell body / ubiquitin-dependent protein catabolic process / microtubule binding / microtubule / molecular adaptor activity / postsynaptic density / axon / centrosome / glutamatergic synapse / protein-containing complex binding / perinuclear region of cytoplasm / endoplasmic reticulum / mitochondrion / identical protein binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 NUDE domain / Disrupted in schizophrenia 1 / NUDE family / NUDE protein, C-terminal conserved region類似検索 - ドメイン・相同性 Disrupted in schizophrenia 1 homolog / Nuclear distribution protein nudE-like 1類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Ye, F. / Yu, C. / Yu, C. / Zhang, M. |
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資金援助 | 香港, 中国, 5件 組織 | 認可番号 | 国 |
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RGC | 664113 | 香港 | RGC | 16103614 | 香港 | RGC | AoE-M09-12 | 香港 | RGC | T13-607/12R | 香港 | Minister of Science and Technology of China | 2014CB910204 | 中国 |
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引用 | ジャーナル: Neuron / 年: 2017 タイトル: DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. 著者: Ye, F. / Kang, E. / Yu, C. / Qian, X. / Jacob, F. / Yu, C. / Mao, M. / Poon, R.Y.C. / Kim, J. / Song, H. / Ming, G.L. / Zhang, M. |
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履歴 | 登録 | 2017年10月2日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2017年11月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月29日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_nmr_software Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name / _pdbx_nmr_software.name |
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改定 1.2 | 2023年6月14日 | Group: Database references / Other / カテゴリ: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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改定 1.3 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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