PROTEIN BINDING / Kinase / Complex / Phosphorylation
Function / homology
Function and homology information
microvillus assembly / vesicle membrane / Golgi-associated vesicle / Golgi cisterna membrane / Apoptotic cleavage of cellular proteins / cellular response to starvation / negative regulation of cell migration / cell periphery / kinase binding / cellular response to oxidative stress ...microvillus assembly / vesicle membrane / Golgi-associated vesicle / Golgi cisterna membrane / Apoptotic cleavage of cellular proteins / cellular response to starvation / negative regulation of cell migration / cell periphery / kinase binding / cellular response to oxidative stress / regulation of apoptotic process / dendritic spine / protein autophosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / apical plasma membrane / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / apoptotic process / perinuclear region of cytoplasm / Golgi apparatus / magnesium ion binding / protein homodimerization activity / extracellular exosome / ATP binding / identical protein binding / membrane / metal ion binding / cytoplasm / cytosol Similarity search - Function
MST4, kinase domain / MOB kinase activator family / MOB kinase activator superfamily / Mob1/phocein family / Mob1/phocein family / Programmed cell death protein 10, dimerisation domain superfamily / : / Programmed cell death protein 10, dimerisation domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...MST4, kinase domain / MOB kinase activator family / MOB kinase activator superfamily / Mob1/phocein family / Mob1/phocein family / Programmed cell death protein 10, dimerisation domain superfamily / : / Programmed cell death protein 10, dimerisation domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
Method to determine structure: SAD / Resolution: 1.897→30.038 Å / SU ML: 0.18 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 19.71 / Stereochemistry target values: ML Details: The number of reflections containing anomalous reflections used in refinement is 18533. Non-anomalous reflections in data collection and refinement are 12086 and 12079 respectively.
Rfactor
Num. reflection
% reflection
Rfree
0.1977
1865
10.06 %
Rwork
0.1527
-
-
obs
0.1572
12079
97.91 %
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement step
Cycle: LAST / Resolution: 1.897→30.038 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
1103
0
2
75
1180
Refine LS restraints
Refine-ID
Type
Dev ideal
Number
X-RAY DIFFRACTION
f_bond_d
0.011
1168
X-RAY DIFFRACTION
f_angle_d
1.246
1589
X-RAY DIFFRACTION
f_dihedral_angle_d
8.527
912
X-RAY DIFFRACTION
f_chiral_restr
0.063
176
X-RAY DIFFRACTION
f_plane_restr
0.007
203
LS refinement shell
Resolution (Å)
Rfactor Rfree
Num. reflection Rfree
Rfactor Rwork
Num. reflection Rwork
Refine-ID
% reflection obs (%)
1.897-1.9483
0.2598
84
0.2432
757
X-RAY DIFFRACTION
48
1.9483-2.0056
0.242
90
0.2134
823
X-RAY DIFFRACTION
50
2.0056-2.0703
0.2168
95
0.1905
847
X-RAY DIFFRACTION
52
2.0703-2.1443
0.2127
103
0.1749
912
X-RAY DIFFRACTION
55
2.1443-2.2301
0.1689
115
0.1559
1020
X-RAY DIFFRACTION
62
2.2301-2.3316
0.1737
138
0.1401
1252
X-RAY DIFFRACTION
77
2.3316-2.4545
0.1907
165
0.144
1428
X-RAY DIFFRACTION
88
2.4545-2.6082
0.1901
185
0.1558
1607
X-RAY DIFFRACTION
96
2.6082-2.8094
0.2112
176
0.1627
1548
X-RAY DIFFRACTION
96
2.8094-3.0919
0.2335
179
0.1647
1631
X-RAY DIFFRACTION
99
3.0919-3.5387
0.1882
174
0.1445
1617
X-RAY DIFFRACTION
99
3.5387-4.456
0.2178
177
0.1318
1607
X-RAY DIFFRACTION
98
4.456-30.042
0.1664
184
0.1497
1619
X-RAY DIFFRACTION
98
Refinement TLS params.
Method: refined / Refine-ID: X-RAY DIFFRACTION
ID
L11 (°2)
L12 (°2)
L13 (°2)
L22 (°2)
L23 (°2)
L33 (°2)
S11 (Å °)
S12 (Å °)
S13 (Å °)
S21 (Å °)
S22 (Å °)
S23 (Å °)
S31 (Å °)
S32 (Å °)
S33 (Å °)
T11 (Å2)
T12 (Å2)
T13 (Å2)
T22 (Å2)
T23 (Å2)
T33 (Å2)
Origin x (Å)
Origin y (Å)
Origin z (Å)
1
7.9843
0.9397
1.9758
2.1276
0.4748
4.2894
0.5181
0.803
-0.9547
-0.8494
-0.1083
0.373
0.9859
0.2336
-0.3532
0.5024
0.0402
-0.1367
0.273
-0.0445
0.3596
-0.786
8.1301
7.9558
2
3.8631
0.8839
0.6126
5.7028
-0.7623
3.2152
-0.0047
-0.1725
0.0489
0.4172
0.0136
0.2876
-0.1409
-0.0402
-0.0125
0.1262
-0.0015
0.0156
0.1227
-0.0103
0.1125
-0.2559
12.0946
26.7066
3
3.5509
0.0667
-0.2656
2.9192
-0.6341
3.0386
0.02
0.2839
-0.3592
-0.3402
0.0316
0.3464
0.3105
-0.2644
-0.019
0.1463
-0.0087
-0.0307
0.1107
-0.0099
0.1496
-3.903
9.5246
16.4
4
1.5544
0.3579
1.9237
2.0067
-0.4962
8.2504
0.098
0.6117
0.2402
-0.5476
0.097
-0.3207
-0.2115
0.6246
-0.3013
0.2695
-0.0582
0.065
0.275
0.0308
0.1798
7.2142
20.0973
8.7536
5
7.9294
0.0282
0.9541
5.2856
0.3099
4.2025
-0.3326
0.3769
0.2932
-0.7115
0.195
0.3544
-0.2925
-0.6097
0.1635
0.2856
-0.0008
-0.0641
0.2342
0.034
0.131
-6.3684
18.1978
5.0262
6
4.8185
2.2675
5.3148
7.3317
3.8785
7.2604
-0.1378
0.2256
0.6801
-0.0644
-0.1655
1.1952
-0.1303
-1.3235
0.2717
0.2496
0.0181
-0.0538
0.533
0.0571
0.4224
-11.185
19.8014
11.9046
7
5.5252
-2.1928
-0.7097
3.6436
0.0971
7.1795
0.0431
-1.3233
0.0732
1.2698
0.2266
0.4893
-0.0237
-0.202
-0.2101
0.2942
0.0146
0.1287
0.4326
-0.0378
0.3538
-11.7517
11.4126
30.4093
Refinement TLS group
ID
Refine-ID
Refine TLS-ID
Selection details
1
X-RAY DIFFRACTION
1
chain 'A' and (resid67through90 )
2
X-RAY DIFFRACTION
2
chain 'A' and (resid91through120 )
3
X-RAY DIFFRACTION
3
chain 'A' and (resid121through173 )
4
X-RAY DIFFRACTION
4
chain 'A' and (resid174through185 )
5
X-RAY DIFFRACTION
5
chain 'A' and (resid186through197 )
6
X-RAY DIFFRACTION
6
chain 'A' and (resid198through210 )
7
X-RAY DIFFRACTION
7
chain 'B' and (resid323through333 )
+
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