- PDB-5xjq: Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in ... -
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基本情報
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データベース: PDB / ID: 5xjq
タイトル
Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human
要素
(Small nuclear ribonucleoprotein ...) x 5
Gem-associated protein 2
Survival motor neuron protein
キーワード
SPLICING
機能・相同性
機能・相同性情報
negative regulation of RNA binding / Gemini of coiled bodies / SMN complex / U7 snRNP / SLBP independent Processing of Histone Pre-mRNAs / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / U12-type spliceosomal complex / methylosome / 7-methylguanosine cap hypermethylation / pICln-Sm protein complex ...negative regulation of RNA binding / Gemini of coiled bodies / SMN complex / U7 snRNP / SLBP independent Processing of Histone Pre-mRNAs / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / U12-type spliceosomal complex / methylosome / 7-methylguanosine cap hypermethylation / pICln-Sm protein complex / RNA splicing, via transesterification reactions / small nuclear ribonucleoprotein complex / SMN-Sm protein complex / spliceosomal tri-snRNP complex / P granule / telomerase holoenzyme complex / U2-type spliceosomal complex / U2-type precatalytic spliceosome / commitment complex / U2-type prespliceosome assembly / U2-type catalytic step 2 spliceosome / U4 snRNP / U2 snRNP / RNA Polymerase II Transcription Termination / U1 snRNP / U2-type prespliceosome / precatalytic spliceosome / spliceosomal complex assembly / mRNA Splicing - Minor Pathway / U5 snRNP / spliceosomal snRNP assembly / Cajal body / U4/U6 x U5 tri-snRNP complex / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / RNA splicing / DNA-templated transcription termination / spliceosomal complex / mRNA processing / cytoplasmic ribonucleoprotein granule / Z disc / mRNA splicing, via spliceosome / nervous system development / snRNP Assembly / SARS-CoV-2 modulates host translation machinery / perikaryon / nuclear body / neuron projection / axon / nucleolus / RNA binding / extracellular exosome / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
Gem-associated protein 2 / Gemin2/Brr1 / Survival motor neuron (SMN) interacting protein 1 (SIP1) / SMN complex subunit Smn1 / : / Survival Motor Neuron, YG-box / Survival Motor Neuron, Gemin2-binding domain / : / Survival motor neuron, Tudor domain / Survival motor neuron protein (SMN), Tudor domain ...Gem-associated protein 2 / Gemin2/Brr1 / Survival motor neuron (SMN) interacting protein 1 (SIP1) / SMN complex subunit Smn1 / : / Survival Motor Neuron, YG-box / Survival Motor Neuron, Gemin2-binding domain / : / Survival motor neuron, Tudor domain / Survival motor neuron protein (SMN), Tudor domain / Tudor domain profile. / Small nuclear ribonucleoprotein D1 / Small nuclear ribonucleoprotein Sm D2 / SH3 type barrels. - #100 / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein G / Small nuclear ribonucleoprotein F / Sm-like protein Lsm7/SmG / Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 / Tudor domain / Tudor domain / Sm-like protein Lsm6/SmF / LSM domain / LSM domain, eukaryotic/archaea-type / snRNP Sm proteins / : / Sm domain profile. / LSM domain superfamily / SH3 type barrels. / Roll / Mainly Beta 類似検索 - ドメイン・相同性
Gem-associated protein 2 / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein F / Small nuclear ribonucleoprotein G / Small nuclear ribonucleoprotein Sm D1 / Small nuclear ribonucleoprotein Sm D2 / Survival motor neuron protein 類似検索 - 構成要素
2: Gem-associated protein 2 A: Small nuclear ribonucleoprotein Sm D1 B: Small nuclear ribonucleoprotein Sm D2 E: Small nuclear ribonucleoprotein E F: Small nuclear ribonucleoprotein F G: Small nuclear ribonucleoprotein G M: Survival motor neuron protein
Gem-associatedprotein2 / Gemin-2 / Component of gems 2 / Survival of motor neuron protein-interacting protein 1 / SMN- ...Gemin-2 / Component of gems 2 / Survival of motor neuron protein-interacting protein 1 / SMN-interacting protein 1
解像度: 3.28→60 Å / Cor.coef. Fo:Fc: 0.919 / Cor.coef. Fo:Fc free: 0.849 / SU B: 23.694 / SU ML: 0.381 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R Free: 0.54 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
反射数
%反射
Selection details
Rfree
0.2618
775
5 %
RANDOM
Rwork
0.1981
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obs
0.2013
14695
79.17 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK