PDB-5w5t: Agrobacterium tumefaciens ADP-Glucose Pyrophosphorylase bound to ...

Basic information

• Entry: Database: PDB / ID: 5w5t
• Title: Agrobacterium tumefaciens ADP-Glucose Pyrophosphorylase bound to activator ethyl pyruvate
• Components: Glucose-1-phosphate adenylyltransferase
• Keywords: TRANSFERASE / Glucose-1-phosphate adenylyltransferase / glycogen biosynthesis / starch biosynthesis / allosterism

Function / homology

Function:

glucose-1-phosphate adenylyltransferase / glucose-1-phosphate adenylyltransferase activity / glycogen biosynthetic process / ATP binding

Domain/homology:

Glucose-1-phosphate adenylyltransferase GlgC, bacterial / ADP-glucose pyrophosphorylase, conserved site / Glucose-1-phosphate adenylyltransferase / ADP-glucose pyrophosphorylase signature 1. / ADP-glucose pyrophosphorylase signature 2. / ADP-glucose pyrophosphorylase signature 3. / : / GlmU-like, C-terminal hexapeptide / Nucleotidyl transferase domain / Nucleotidyl transferase / Hexapeptide repeat proteins / UDP N-Acetylglucosamine Acyltransferase; domain 1 / Trimeric LpxA-like superfamily / 3 Solenoid / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Nucleotide-diphospho-sugar transferases / Alpha-Beta Complex / Mainly Beta / Alpha Beta

Component:

ethyl 2-oxopropanoate / Glucose-1-phosphate adenylyltransferase

• Biological species: Rhizobium radiobacter (Agrobacterium genomosp. 4)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.76 Å
• Authors: Mascarenhas, R.N. / Hill, B.L. / Ballicora, M.A. / Liu, D.

Funding support

United States, 1items

Organization	Grant number	Country
National Science Foundation (NSF, United States)	MCB1616851	United States

• Citation: Journal: J. Biol. Chem. / Year: 2019; Title: Structural analysis reveals a pyruvate-binding activator site in theAgrobacterium tumefaciensADP-glucose pyrophosphorylase.; Authors: Hill, B.L. / Mascarenhas, R. / Patel, H.P. / Asencion Diez, M.D. / Wu, R. / Iglesias, A.A. / Liu, D. / Ballicora, M.A.

History

Deposition	Jun 15, 2017	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Nov 14, 2018	Provider: repository / Type: Initial release
Revision 1.1	Nov 21, 2018	Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_abbrev / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2	Feb 20, 2019	Group: Author supporting evidence / Data collection / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.3	Nov 27, 2019	Group: Author supporting evidence / Database references / Category: citation / pdbx_audit_support Item: _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _pdbx_audit_support.funding_organization
Revision 2.0	Mar 31, 2021	Group: Atomic model / Data collection / Refinement description Category: atom_site / pdbx_nonpoly_scheme / pdbx_refine_tls_group / refine / refine_hist / refine_ls_restr / refine_ls_shell Item: _atom_site.Cartn_x / _pdbx_nonpoly_scheme.auth_mon_id / _pdbx_nonpoly_scheme.auth_seq_num / _pdbx_refine_tls_group.beg_auth_asym_id / _pdbx_refine_tls_group.beg_auth_seq_id / _pdbx_refine_tls_group.end_auth_asym_id / _pdbx_refine_tls_group.end_auth_seq_id / _pdbx_refine_tls_group.selection_details / _refine.B_iso_max / _refine.B_iso_mean / _refine.B_iso_min / _refine.ls_R_factor_R_free / _refine.ls_R_factor_R_work / _refine.ls_R_factor_obs / _refine.ls_d_res_high / _refine.ls_number_reflns_R_work / _refine.ls_percent_reflns_obs / _refine_hist.cycle_id / _refine_hist.d_res_high / _refine_hist.number_atoms_total / _refine_hist.pdbx_B_iso_mean_ligand / _refine_hist.pdbx_B_iso_mean_solvent / _refine_hist.pdbx_number_atoms_ligand / _refine_hist.pdbx_number_residues_total / _refine_ls_restr.dev_ideal / _refine_ls_restr.number / _refine_ls_restr.type / _refine_ls_shell.R_factor_R_free_error / _refine_ls_shell.number_reflns_all / _refine_ls_shell.pdbx_total_number_of_bins_used
Revision 2.1	Mar 13, 2024	Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Assembly

Deposited unit

A: Glucose-1-phosphate adenylyltransferase

B: Glucose-1-phosphate adenylyltransferase

C: Glucose-1-phosphate adenylyltransferase

D: Glucose-1-phosphate adenylyltransferase

E: Glucose-1-phosphate adenylyltransferase

F: Glucose-1-phosphate adenylyltransferase

G: Glucose-1-phosphate adenylyltransferase

H: Glucose-1-phosphate adenylyltransferase

I: Glucose-1-phosphate adenylyltransferase

J: Glucose-1-phosphate adenylyltransferase

K: Glucose-1-phosphate adenylyltransferase

L: Glucose-1-phosphate adenylyltransferase

M: Glucose-1-phosphate adenylyltransferase

N: Glucose-1-phosphate adenylyltransferase

O: Glucose-1-phosphate adenylyltransferase

P: Glucose-1-phosphate adenylyltransferase

Q: Glucose-1-phosphate adenylyltransferase

R: Glucose-1-phosphate adenylyltransferase

Z: Glucose-1-phosphate adenylyltransferase

T: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• 942 kDa, 20 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	941,950	151
Polymers	929,348	20
Non-polymers	12,602	131
Water	202,795	11257

1

A: Glucose-1-phosphate adenylyltransferase

B: Glucose-1-phosphate adenylyltransferase

C: Glucose-1-phosphate adenylyltransferase

D: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• defined by author&software
• Evidence: gel filtration
• 189 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	188,556	32
Polymers	185,870	4
Non-polymers	2,686	28
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	18210 Å2
ΔGint	-251 kcal/mol
Surface area	61370 Å2
Method	PISA

2

Q: Glucose-1-phosphate adenylyltransferase

R: Glucose-1-phosphate adenylyltransferase

hetero molecules

E: Glucose-1-phosphate adenylyltransferase

F: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• defined by author&software
• 189 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	188,664	33
Polymers	185,870	4
Non-polymers	2,794	29
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1
crystal symmetry operation	1_545	x,y-1,z	1

Calculated values:

Buried area	18880 Å2
ΔGint	-298 kcal/mol
Surface area	61020 Å2
Method	PISA

3

O: Glucose-1-phosphate adenylyltransferase

P: Glucose-1-phosphate adenylyltransferase

hetero molecules

G: Glucose-1-phosphate adenylyltransferase

H: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• defined by author&software
• 188 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	188,091	27
Polymers	185,870	4
Non-polymers	2,222	23
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1
crystal symmetry operation	1_545	x,y-1,z	1

Calculated values:

Buried area	17700 Å2
ΔGint	-242 kcal/mol
Surface area	60590 Å2
Method	PISA

4

I: Glucose-1-phosphate adenylyltransferase

J: Glucose-1-phosphate adenylyltransferase

M: Glucose-1-phosphate adenylyltransferase

N: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• defined by author&software
• 189 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	188,548	32
Polymers	185,870	4
Non-polymers	2,678	28
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	18680 Å2
ΔGint	-233 kcal/mol
Surface area	61330 Å2
Method	PISA

5

K: Glucose-1-phosphate adenylyltransferase

L: Glucose-1-phosphate adenylyltransferase

Z: Glucose-1-phosphate adenylyltransferase

T: Glucose-1-phosphate adenylyltransferase

hetero molecules

Summary:

• defined by author&software
• 188 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	188,091	27
Polymers	185,870	4
Non-polymers	2,222	23
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	16680 Å2
ΔGint	-242 kcal/mol
Surface area	61200 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	93.781, 140.145, 228.855
Angle α, β, γ (deg.)	107.81, 101.84, 90.06
Int Tables number	1
Space group name H-M	P1

Components

#1: Protein

A B C D E F G H I J K L M N O P Q R Z T
Glucose-1-phosphate adenylyltransferase / ADP-glucose pyrophosphorylase / ADPGlc PPase / ADP-glucose synthase

Details:

Mass: 46467.398 Da / Num. of mol.: 20
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Rhizobium radiobacter (Agrobacterium genomosp. 4)
Gene: glgC / Production host: Escherichia coli K-12 (bacteria)
References: UniProt: P39669, glucose-1-phosphate adenylyltransferase

#2: Chemical

A-501 A-502 A-503 A-504 B-501 B-502 B-503 C-501 C-502 C-503 C-504 D-501 D-502 D-503 D-504 E-501 E-502 E-503 F-501 F-502 ...
ChemComp-SO4 / SULFATE ION

Details:

Mass: 96.063 Da / Num. of mol.: 75 / Source method: obtained synthetically / Formula: SO₄

#3: Chemical

A-505 B-504 B-505 B-506 C-505 C-506 C-507 C-508 D-505 D-506 D-507 E-504 G-504 G-505 H-503 I-505 I-506 I-507 J-504 J-505 ...
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL

Details:

Mass: 92.094 Da / Num. of mol.: 46 / Source method: obtained synthetically / Formula: C₃H₈O₃

#4: Chemical

A-506 D-508 F-503 G-506 I-508 L-507 M-508 O-508 R-511 Z-506
ChemComp-9X7 / ethyl 2-oxopropanoate

Details:

Mass: 116.115 Da / Num. of mol.: 10 / Source method: obtained synthetically / Formula: C₅H₈O₃

#5: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 11257 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 3.01 ų/Da / Density % sol: 59.12 %
• Crystal grow: Temperature: 277 K / Method: vapor diffusion, hanging drop / Details: 50mM HEPES pH7.5, 1.5M LiSO4

Data collection

• Diffraction: Mean temperature: 80 K
• Diffraction source: Source: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.98 Å
• Detector: Type: MARRESEARCH / Detector: CCD / Date: Apr 15, 2016
• Radiation: Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.98 Å / Relative weight: 1
• Reflection twin: Operator: h,-k,-h-l / Fraction: 0.5
• Reflection: Resolution: 1.76→50 Å / Num. obs: 1035315 / % possible obs: 97.1 % / Redundancy: 2.1 % / R_merge(I) obs: 0.05 / R_pim(I) all: 0.046 / R_rim(I) all: 0.068 / Χ²: 0.926 / Net I/σ(I): 8.7 / Num. measured all: 2210333

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	Rmerge(I) obs	Num. unique all	CC1/2	Rpim(I) all	Rrim(I) all	Χ2	% possible all
1.76-1.79	1.9	0.618	48723	0.736	0.556	0.833	0.899	91.5
1.79-1.82	1.9	0.509	50796	0.795	0.458	0.686	0.9	95.3
1.82-1.86	2.1	0.44	51254	0.831	0.394	0.593	0.912	96
1.86-1.9	2.2	0.355	51358	0.881	0.318	0.478	0.93	96.4
1.9-1.94	2.2	0.28	51643	0.917	0.25	0.377	0.943	96.6
1.94-1.98	2.2	0.232	51566	0.94	0.208	0.313	0.964	96.7
1.98-2.03	2.2	0.182	51651	0.962	0.164	0.246	0.969	96.9
2.03-2.09	2.2	0.149	51694	0.974	0.134	0.201	0.984	97
2.09-2.15	2.2	0.128	51747	0.981	0.115	0.172	0.974	97.2
2.15-2.22	2.2	0.105	52075	0.987	0.094	0.141	0.981	97.3
2.22-2.3	2.2	0.087	51824	0.99	0.078	0.118	0.964	97.4
2.3-2.39	2.2	0.074	52021	0.993	0.067	0.1	0.956	97.6
2.39-2.5	2.2	0.065	52175	0.994	0.059	0.088	0.936	97.8
2.5-2.63	2.2	0.054	52284	0.995	0.049	0.074	0.92	98
2.63-2.79	2.2	0.046	52345	0.997	0.042	0.062	0.906	98.2
2.79-3.01	2.2	0.037	52518	0.997	0.034	0.05	0.898	98.4
3.01-3.31	2.2	0.034	52510	0.996	0.031	0.046	0.955	98.5
3.31-3.79	2.1	0.031	52548	0.996	0.029	0.042	1.052	98.6
3.79-4.78	2.1	0.026	52620	0.997	0.024	0.035	0.867	98.7
4.78-50	2.1	0.023	51963	0.998	0.021	0.031	0.594	97.4

Processing

Software

Name	Version	Classification
PHENIX	1.9_1692	refinement
HKL-3000		data scaling
PDB_EXTRACT	3.22	data extraction
HKL-3000		data reduction
PHASER		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.76→41.26 Å / Cross valid method: FREE R-VALUE / σ(F): 1.96 / Phase error: 23.89 / Stereochemistry target values: TWIN_LSQ_F

	Rfactor	Num. reflection	% reflection
Rfree	0.207	50673	5.2 %
Rwork	0.163	-	-
obs	0.166	974344	91.1 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso mean: 25.64 Ų

Refinement step

Cycle: LAST / Resolution: 1.76→41.26 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	64362	0	731	11257	76350

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.007	66593
X-RAY DIFFRACTION	f_angle_d	1.106	90425
X-RAY DIFFRACTION	f_dihedral_angle_d	13.604	24222
X-RAY DIFFRACTION	f_chiral_restr	0.043	9789
X-RAY DIFFRACTION	f_plane_restr	0.005	11798

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
1.7629-1.7933	0.2896	956	0.2617	20078	X-RAY DIFFRACTION	38
1.7933-1.8259	0.2814	1439	0.2472	27952	X-RAY DIFFRACTION	52
1.8259-1.861	0.2529	2035	0.2355	39001	X-RAY DIFFRACTION	73
1.861-1.899	0.2562	2393	0.2223	46186	X-RAY DIFFRACTION	87
1.899-1.9403	0.2557	2510	0.2081	48749	X-RAY DIFFRACTION	91
1.9403-1.9854	0.2375	2682	0.2014	48843	X-RAY DIFFRACTION	92
1.9854-2.035	0.2368	2506	0.1939	49368	X-RAY DIFFRACTION	92
2.035-2.09	0.2185	2673	0.1894	49092	X-RAY DIFFRACTION	92
2.09-2.1515	0.2251	2527	0.1874	49322	X-RAY DIFFRACTION	92
2.1515-2.221	0.2215	2632	0.1836	49540	X-RAY DIFFRACTION	92
2.221-2.3003	0.2167	2519	0.1754	49465	X-RAY DIFFRACTION	93
2.3003-2.3924	0.2286	2634	0.1727	49493	X-RAY DIFFRACTION	93
2.3924-2.5013	0.2173	2653	0.1735	49638	X-RAY DIFFRACTION	93
2.5013-2.6331	0.2159	2727	0.1692	49657	X-RAY DIFFRACTION	93
2.6331-2.798	0.2083	2805	0.1645	49704	X-RAY DIFFRACTION	93
2.798-3.0139	0.2032	2650	0.1528	49965	X-RAY DIFFRACTION	93
3.0139-3.317	0.2001	2528	0.1456	50057	X-RAY DIFFRACTION	94
3.317-3.7965	0.1735	2371	0.1247	50308	X-RAY DIFFRACTION	94
3.7965-4.7813	0.1547	2524	0.1094	50113	X-RAY DIFFRACTION	94
4.7813-35.1691	0.2102	2513	0.1837	49508	X-RAY DIFFRACTION	93

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.0131	-0.0103	0.0018	0.0198	0.0015	0.0058	0.053	0.008	-0.022	-0.0588	0.0226	0.023	-0.015	-0.0106	0.0308	0.1526	0.029	-0.0136	0.0831	0.0216	0.0446	-43.4698	-28.4975	58.6602
2	0.0027	-0.0029	-0.0003	0.011	-0.0044	0.0061	0.0434	0.0072	-0.0246	-0.0592	0.04	0.0488	0.0304	-0.0162	0.0221	0.1451	0.0303	-0.026	0.091	0.0158	0.0766	-46.3526	-36.9892	59.5297
3	0.014	-0.0053	0.0083	0.0027	-0.0033	0.0037	0.0006	0.0072	-0.0033	-0.0089	-0.0039	0.0153	-0.0029	-0.0106	-0.0117	0.199	0.0954	-0.1462	0.2019	0.1249	0.2338	-65.3987	-22.4621	51.9597
4	0.0029	0.001	0.0021	-0.0002	0.0017	0.0005	0.005	0.0329	-0.0072	-0.0186	0.0257	0.0241	0.0132	-0.0123	0.0062	0.1741	0.0157	-0.1394	0.1859	0.0441	0.1629	-59.5309	-36.9826	49.8996
5	0.0029	-0.0008	-0.005	0.0048	0.0043	0.0145	0.0097	-0.0049	0.0097	-0.0285	0.0172	0.0257	-0.0156	0.0047	0.0031	0.1206	0.0361	0.0314	0.0889	0.0294	0.0997	-46.8203	-15.6228	66.4138
6	0.0461	0.0276	-0.0062	0.0135	-0.01	0.01	-0.0071	0.0654	0.0507	-0.0637	0.0123	-0.0177	-0.0184	0.0231	-0.0189	0.1297	-0.0281	0.2041	0.032	0.0813	0.0432	-28.6786	-4.6753	60.1127
7	0.002	0.0024	0.0051	0.0099	0.0016	0.0094	-0.0057	-0.0031	-0.0074	0.0275	0.0489	-0.0503	-0.0079	0.0004	0.0244	0.0715	-0.0063	0.0049	0.0923	-0.0254	0.0898	-20.9901	-31.0436	88.2973
8	0.0002	0.0004	0.0002	0.0004	-0.0004	0.0003	-0.0158	-0.0109	-0.009	0.0091	0.0067	-0.0014	0.011	-0.0092	-0	0.1478	0.0044	-0.0571	0.1145	-0.0388	0.0998	-19.1909	-42.2454	97.1781
9	0.0017	0.0011	-0.0016	0.0009	-0.0036	0.0107	-0.0148	-0.0063	0.0114	0.029	-0.0101	-0.0377	-0.0103	0.0203	-0.0337	0.0253	-0.0406	-0.0938	0.0838	-0.16	0.241	-0.2984	-26.6511	92.486
10	0.0043	-0.0023	-0.0012	0.0007	-0.0009	0.002	-0.0056	-0.0149	0.0107	0.0269	0.0149	-0.0318	0.0155	0.0161	-0.0004	0.139	0.035	-0.0978	0.1524	-0.0935	0.2235	-3.0326	-37.503	98.7055
11	0.0064	-0.0006	-0.0099	0.0023	-0.0006	0.0359	0.0085	-0.0105	0.0368	-0.0137	0.0308	-0.0624	-0.0475	-0.0249	0.0069	0.0859	-0.0112	0.0432	0.0797	-0.0285	0.1473	-22.4487	-12.2592	80.7074
12	0.0063	-0.0006	-0.0019	0.0148	-0.0015	0.0036	-0.004	-0.0219	0.0158	0.0178	0.0065	-0.0099	-0.0131	-0.0285	0.001	0.1052	0.0374	0.0936	0.116	-0.0624	0.0954	-34.5406	-5.2096	88.5767
13	0.0004	0.0003	-0.0005	0.0006	-0.0001	0.001	-0.0015	-0.0131	0.0059	0.0145	0.0144	-0.0062	-0.0024	-0.0124	0	0.2258	0.048	0.0151	0.2091	-0.0869	0.146	-31.5016	-5.4529	102.4974
14	0.0113	0.0029	-0.0012	0.0171	-0.0011	0.0144	0.025	-0.0104	0.006	0.0386	0.0422	0.0444	-0.0005	-0.0101	0.0437	0.0551	0.0021	-0.0016	0.0711	0.0142	0.0717	-40.2805	-44.5848	88.924
15	-0.0001	0.0002	0.0001	0.0008	0.0007	0.001	-0.0056	-0.0116	0.0056	0.0047	0.004	-0.0006	-0.0037	0.0098	0	0.2298	-0.0093	0.0512	0.1726	0.0138	0.1349	-41.9549	-34.0092	100.2534
16	0.0077	-0.0017	-0.0008	0.0073	0.004	0.0025	-0.0095	-0.0047	0	0.0115	0.0043	0.0371	0.0013	-0.0134	-0.0117	0.0401	-0.0014	0.0469	0.1049	0.071	0.172	-57.455	-46.6993	91.0706
17	0.0061	-0.0005	-0.004	0.0028	-0.0016	0.0028	0.0161	-0.0267	-0.0106	0.0173	0.007	0.0228	-0.0076	-0.0489	0.0062	0.0915	-0.0307	0.1513	0.1187	0.0845	0.2066	-61.8228	-46.205	99.6455
18	0.0016	0.0008	0.0007	-0.0003	0.0013	0.0028	0.0029	-0.0089	-0.0025	0.0266	0.0103	0.0244	-0.0146	-0.0066	0.0032	0.1618	0.0029	0.0993	0.1605	0.0604	0.1702	-58.6463	-42.5281	101.7695
19	0.0034	-0.0037	-0.0005	0.0042	0.0013	0.0004	0.0045	0.0015	-0.0269	-0.0111	0.0276	0.0165	-0.001	0.0158	0.007	0.0238	-0.0184	-0.0038	0.0649	0.0275	0.1215	-46.0285	-60.0883	83.1835
20	0.0136	-0.0031	-0.0036	0.0042	0.0003	0.0079	0.0003	-0.0444	-0.042	0.0059	0.0061	0.0053	0.0203	0.0297	-0.01	0.0556	0.0238	-0.0537	0.0838	0.0285	0.1104	-26.6336	-71.0562	83.7849
21	0.0036	0.002	0.0031	0.001	0.0012	0.0025	0.0029	-0.0065	-0.0078	0.0133	0.0089	0.0086	0.0053	0.0108	0.0048	0.1736	0.0467	-0.0226	0.154	0.0764	0.1019	-29.0427	-71.0823	101.4486
22	0.012	-0.0089	0.0159	0.0145	-0.0176	0.0308	0.0539	0.0088	0.0309	-0.0547	0.0246	-0.0241	0.0069	0.0305	0.0681	0.1561	0.0395	0.0638	0.0729	-0.0353	0.0646	-20.4212	-46.8974	57.4856
23	0.0085	0.0032	-0.0069	0.0017	-0.0021	0.0059	0.0345	-0.0002	0.0185	-0.024	0.0075	-0.0015	-0.0035	0.0071	0.01	0.1443	0.0327	0.0187	0.1026	-0.0145	0.083	-26.1628	-38.2969	58.9622
24	0.0099	0.0055	-0.001	0.0108	-0.0038	0.0036	0.0062	0.0181	0.0056	-0.0221	-0.0027	-0.0282	-0.0163	0.0066	-0.0102	0.1168	0.0482	0.1551	0.0485	-0.0351	0.1101	-8.2477	-42.63	55.6463
25	0.0013	-0.0009	-0.0005	0.0003	0.0003	0.0003	0.0019	0.0058	0.0063	-0.0008	0.0026	-0.0092	-0.0011	0.0031	-0.0011	0.1907	0.0813	0.1104	0.1971	-0.0321	0.1953	3.9758	-52.6751	47.0855
26	0.0007	0	0.0002	0	0	0.0018	0.0017	0.0103	0.0043	-0.0031	0.0072	-0.0039	-0.0007	0.0079	-0.004	0.1937	0.0315	0.114	0.1213	0.0065	0.1799	-6.4731	-38.1958	49.8077
27	0.0013	-0.0007	-0.0003	-0.0001	-0.0003	0.0004	0.0024	0.0076	-0.0032	-0.0143	0.0006	-0.0097	-0.0041	-0.0017	0	0.2021	0.0325	0.1142	0.189	-0.0015	0.1874	-4.3775	-41.7776	45.7944
28	0.0063	0.0023	0.0012	0.0039	-0.0001	0.0002	0.0216	0.0011	-0.0106	-0.0099	0.001	-0.0133	0.0098	0.003	0.0094	0.1304	0.0223	0.0244	0.0946	-0.0294	0.1006	-14.4242	-61.5321	63.9863
29	0.0075	-0.0031	-0.0093	0.0115	0.0104	0.0139	0.0224	-0.0004	-0.0217	-0.0102	0.0209	0.0023	0.0191	-0.0062	0.0268	0.0468	0.0099	-0.0601	0.0428	-0.0032	0.0885	-34.2456	-67.2915	70.7247
30	0.0083	-0.0002	0.0051	0.0024	-0.0016	0.0061	-0.0026	0.027	-0.0124	-0.015	-0.001	0.0046	-0.0029	-0.0169	-0.006	0.1436	-0.0034	-0.1167	0.1133	-0.0569	0.0966	-35.4551	-70.6238	59.208
31	0.0007	-0.0012	0.0012	0.0017	-0.0012	0.0018	-0.0016	0.0089	-0.0052	-0.0145	0.0121	-0.001	0.0032	-0.0133	0.0025	0.2009	0.0198	-0.074	0.1797	-0.0818	0.1114	-33.5158	-70.5251	46.1728
32	0.0057	0.0023	-0.0027	0.0234	0.0037	0.0054	0.0374	-0.0156	0.0093	0.0505	0.0236	0.0266	0.007	-0.0121	0.0315	0.091	-0.0212	-0.0211	0.0946	0.0362	0.111	5.0057	25.5057	130.6408
33	-0.0002	0.0003	0.0001	0.0009	0.0007	0.0004	-0.0045	-0.0155	0.0038	-0.0002	0.0025	-0.0095	-0.0026	0.0067	-0	0.2316	-0.0169	0.0586	0.1797	0.0091	0.1497	2.6143	36.3036	141.5246
34	0.0039	0.0006	0.0018	-0.0005	0.0012	0.0069	0.0187	-0.0225	0.0036	0.0416	-0	0.0524	-0.0057	-0.0414	-0.0027	0.047	-0.0461	0.1075	0.0884	0.1611	0.1939	-14.7969	23.5147	135.5876
35	0.0173	0.0222	0.0109	0.0322	0.0224	0.055	0.0377	-0.0159	-0.036	0.0388	0.0596	0.0429	-0.0025	-0.0186	0.0359	0.0914	-0.0239	0.0004	0.1176	0.0694	0.1553	-5.0156	16.0718	130.7224
36	0.0144	-0.0048	-0.0047	0.0018	0.0045	0.0309	-0.0099	-0.0466	-0.0374	0.0141	0.0119	-0.0031	0.0184	0.0288	-0.0066	0.093	0.035	-0.1314	0.0532	0.0624	0.1184	19.0993	-1.1047	127.0857
37	0.0029	0.0026	0.0049	0.002	0.0037	0.0076	0.0007	-0.0041	-0.0003	0.014	0.0088	0.0015	0.0048	0.0181	0.0098	0.2046	0.0347	-0.0546	0.1787	0.1091	0.1343	15.3174	-0.866	144.5525
38	0.0064	-0.0027	0.0024	0.012	-0.0121	0.0157	0.0301	0.0124	-0.0025	-0.0523	0.0324	-0.0197	0.0085	0.003	0.0322	0.0946	0.0244	-0.0215	0.0924	-0.05	0.0965	25.9625	23.0976	101.1957
39	0.0067	0.0003	-0.0022	0.0004	0.0003	0.0013	0.0008	0.0172	0.0022	-0.0132	0.0018	-0.0029	0.0018	0.0017	0.0017	0.0985	0.0108	0.0121	0.1041	-0.0285	0.0787	24.3917	33.7	101.1563
40	0.0065	0.0068	-0.0094	0.019	-0.0184	0.0202	0.0345	0.019	0.0053	-0.0135	0.0244	-0.0438	-0.0331	0.0186	0.0247	0.0902	0.0216	0.0279	0.091	-0.0928	0.1373	37.5797	31.2167	102.4023
41	0.0063	-0.0018	-0.0035	0.0016	0.0025	0.0014	0.0038	0.0036	0.0055	-0.0106	-0.0107	-0.0078	0.008	0.0129	-0.0077	0.1164	0.0687	0.1249	0.1392	-0.1525	0.2355	49.5887	16.7053	94.4952
42	0.0054	0.0015	-0.0027	-0	-0.0018	0.0005	0.0092	0.024	-0.0043	-0.0263	0.0175	-0.0275	-0.0183	0.0155	0.0051	0.1812	0.0077	0.1106	0.1937	-0.0984	0.2094	43.5214	31.3546	92.3114
43	0.0069	-0.0058	-0.0004	0.0117	-0.0038	0.0067	0.0084	0.0026	-0.018	-0.0007	0.0301	-0.024	0.0126	-0.009	0.0042	0.075	0.0339	-0.0335	0.0911	-0.0409	0.1489	30.9575	9.7363	108.8294
44	0.0137	0.0039	-0.0029	0.0014	-0.002	0.0251	-0.0127	0.0423	-0.0327	-0.0063	-0.0049	0.0057	0.0125	-0.0275	-0.0217	0.0964	-0.0276	-0.1284	0.0497	-0.0586	0.13	11.8522	-1.2511	106.359
45	0.0013	-0.0016	0.003	0.0015	-0.0025	0.0056	-0.0057	0.0072	-0.0037	-0.0153	0.0132	-0.0071	-0.0002	-0.0172	0.01	0.2284	-0.024	-0.0666	0.1906	-0.0958	0.1628	15.5264	-0.9187	88.9831
46	0.0119	0.004	-0.0004	0.0109	0.0126	0.0276	0.0157	0.002	0.0319	0.0555	0.0406	0.0568	0.0187	-0.0066	0.0295	0.0903	0.0006	0.0169	0.0718	0.0321	0.0856	4.8318	23.5084	47.6731
47	0.0012	-0.0003	-0.0009	0.0015	-0.0006	0.0004	-0.0069	0.0017	0.0071	0.0356	0.0071	0.0213	-0.003	0.0075	-0.0003	0.129	0.0008	0.037	0.0836	0.0279	0.1112	4.3651	36.1925	49.4021
48	0.0072	0.0067	0.0011	0.0156	-0.0038	0.0046	-0.0168	0.0063	0.0111	0.012	-0.0075	0.0269	0.0061	-0.0156	-0.0228	0.0793	-0.0001	0.0651	0.1093	0.0936	0.2208	-12.0318	23.5952	47.1746
49	0.0009	0.0006	-0.001	0.0002	-0.0007	0.0006	0.0021	-0.0003	0.0013	0.0043	-0.0064	0.01	-0.0017	-0.0075	-0	0.2715	-0.0474	0.1114	0.3051	0.0779	0.3548	-21.7484	17.4285	56.768
50	0.0016	-0.0017	-0.0036	0.002	0.0032	0.0058	0.0016	-0.0031	-0.0006	0.0088	-0.0006	0.005	-0.0119	-0.011	-0.009	0.1347	0.0032	0.1117	0.0851	0.0569	0.1932	-11.4847	31.8991	54.3703
51	0.001	0.0011	-0.0006	-0.0003	0.0008	0.0003	-0.002	-0.0044	-0.0007	0.025	0.0136	0.0152	-0.0108	-0.0091	-0	0.2016	0.0096	0.1066	0.2117	0.0484	0.2509	-14.027	28.094	57.5729
52	0.0013	-0.0015	-0.0011	0.0044	0.0036	0.0017	-0	-0.007	-0.0246	0.0053	0.0382	0.0332	0.0159	0.0125	0	0.0632	-0.0042	-0.002	0.0655	0.0252	0.1332	-0.1323	10.0314	40.5132
53	0.0094	-0.0024	-0.0014	0.0038	-0.0031	0.0133	0.0111	-0.0464	-0.037	0.0373	0.0322	0.0092	0.0212	0.0311	0.0032	0.1591	0.0483	-0.0681	0.1053	0.0088	0.0798	19.145	-0.7774	42.5932
54	0.0038	0.0031	0.0022	0.0023	0.0015	0.0014	0.0023	-0.0114	-0.0084	0.0136	0.0089	0.0089	0.0023	0.0097	0.0023	0.2461	0.0439	-0.0121	0.1913	0.0693	0.0859	15.8419	-0.113	60.0921
55	0.0035	-0.0065	0.0058	0.0251	-0.0244	0.0288	0.0468	-0.0016	0.0351	-0.0871	0.0383	-0.0447	0.0272	0.0106	0.0339	0.1634	0.0149	0.0296	0.0779	-0.0203	0.0768	25.1704	22.8614	16.0305
56	0.0013	-0.0002	-0.0004	0.0005	-0.0003	0.0018	-0.0005	-0.0092	0.02	-0.0237	-0.002	-0.0104	0.0004	0.0009	-0.0004	0.1813	0.0026	0.0636	0.0905	-0.0135	0.0913	25.7824	35.2744	13.989
57	0.0056	0.0012	-0.0006	-0.0007	0.0008	0.0039	0.001	0.0187	0.01	-0.0109	-0.008	-0.0132	0.005	0.0314	-0.0128	0.126	0.0517	0.2034	0.1063	-0.1017	0.2092	45.6347	20.2744	12.9395
58	0.0003	0.0004	-0.0007	0.0001	-0.0004	0.0008	0.0021	0.0161	0.0049	-0.0085	-0.0027	0.0026	-0.0025	0.0014	0	0.2335	-0.017	0.1242	0.2032	-0.01	0.1946	39.1492	33.9672	4.1131
59	0.0047	-0.0008	0.007	0.0006	-0.001	0.0143	0.0165	0.0077	-0.0047	-0.0117	0.0163	-0.0137	0.0045	0.0082	0.0042	0.1293	0.0301	0.0891	0.1552	-0.052	0.1937	42.2317	17.7968	16.4441
60	0.0012	0.0007	-0.0002	0.001	0.0002	-0.0005	0.0035	-0.0062	-0.0082	-0.0157	0.0082	-0.0192	0.0149	-0.0095	0	0.1374	0.0218	0.0041	0.1127	-0.0321	0.1115	29.0862	6.3158	23.705
61	0.0027	0.0054	-0.0022	0.0184	0.0093	0.0032	0.0318	0.0263	-0.0398	-0.0467	0.0236	0.0195	0.0517	-0.0118	0.0347	0.1842	-0.0357	-0.1576	0.0661	-0.0318	0.0516	11.9562	0.4894	22.5613
62	0.0026	-0.0037	0.0039	0.0043	-0.0047	0.0063	-0.0033	0.0131	-0.0089	-0.0167	0.0145	-0.0053	-0.0031	-0.0106	0.0043	0.2845	-0.0011	-0.0763	0.1855	-0.0848	0.0985	14.27	-1.4231	4.7196
63	0.0087	0.0126	0.0063	0.0266	0.0151	0.0103	0.0754	-0.012	0.0475	0.0767	0.0227	0.0328	0.0103	-0.0327	0.0668	0.1541	-0.0464	0.0454	0.0558	0.0302	0.0449	-40.6036	-44.2446	174.1026
64	-0.0009	0.0008	-0.0004	0.0008	0.0004	0.0007	0.0089	-0.0179	0.0161	0.0231	-0.0013	0.0079	-0.0144	0.0097	-0.0037	0.1529	-0.0491	0.0987	0.0479	0.0048	0.0714	-46.0044	-37.4907	180.7239
65	0.0028	0.0005	-0.0056	0.0006	-0.0025	0.0054	0.0121	-0.0175	0.0117	0.0071	0.0001	0.0166	0.002	-0.026	-0.0012	0.1437	-0.0712	0.1943	0.1243	0.0507	0.1995	-63.5884	-50.6619	181.558
66	0.0021	-0.0007	-0	-0.0003	0.001	-0	0.005	-0.0175	0.0076	0.0228	0.0149	0.0176	-0.0148	-0.0115	0.0023	0.2355	-0.015	0.1504	0.1576	-0.0061	0.2023	-57.5273	-38.4149	186.1551
67	0.0042	0.0032	-0.0015	0.0149	0.0098	0.0162	0.026	-0.0034	-0.0164	0.0144	0.0199	0.0134	0.0135	0.0118	0.0087	0.1121	-0.0273	0.0131	0.0786	0.0145	0.0806	-46.3532	-59.9344	168.7464
68	0.0075	-0.0026	-0.0057	0.0035	0.0016	0.0053	0.004	-0.0443	-0.0357	0.033	-0.0051	-0.018	0.007	0.0239	-0.0148	0.1109	0.0029	-0.1237	0.0866	0.0513	0.0976	-26.9889	-70.8611	169.6581
69	0.0022	0.0034	0.0042	0.0041	0.0046	0.0066	-0.0005	-0.0073	-0.0072	0.0145	0.0149	0.0044	0.0001	0.0151	0.0094	0.206	-0.0204	-0.0821	0.1744	0.0894	0.0887	-29.3329	-70.4721	187.2819
70	0.0069	-0.0004	0.0019	0.0237	-0.021	0.0259	0.0227	0.0043	0.0157	-0.0396	0.0548	-0.0378	0.0094	-0.0046	0.0409	0.0493	0.0014	0.0041	0.0813	-0.037	0.0768	-22.377	-46.8705	142.9655
71	0.0067	0.0013	-0.0032	0.0027	-0.0003	0.0018	-0.0077	0.0007	0.0075	-0.01	0.0095	-0.0072	-0.0018	-0.001	0.0016	0.13	0.0042	0.0188	0.1122	-0.0276	0.1065	-24.3967	-36.1841	143.8407
72	0.0117	0.0045	-0.0079	0.01	-0.0002	0.0202	-0.0046	0.0155	-0.0115	-0.016	0.0125	-0.0417	-0.0199	0.0077	-0.0047	0.0278	0.0023	0.0682	0.0742	-0.0781	0.1333	-8.4983	-42.927	140.8039
73	0.0031	0.001	-0.0036	0.0005	-0.0011	0.0016	0.0044	0.0159	-0.0043	-0.0141	0.0023	-0.0176	-0.0086	0.0344	-0.0008	0.0835	0.0172	0.1205	0.1269	-0.0861	0.1968	-1.1198	-46.2866	133.8696
74	0.0021	-0.0014	-0.0009	-0.0004	-0.0004	0.0002	0.0012	0.0103	-0.0043	-0.022	0.0131	-0.0229	-0.0089	0.0079	0	0.1365	0.0171	0.0814	0.1784	-0.0452	0.1672	-4.6555	-41.8773	130.8059
75	0.0036	0.0064	-0.0004	0.0156	-0.0009	-0.0001	-0.0018	-0.0035	-0.027	0.0065	0.0074	-0.0236	0.0034	0.0048	-0.0001	0.0596	0.0032	0.01	0.1116	-0.029	0.1571	-14.7488	-61.6988	149.5559
76	0.0098	0.0102	-0.0045	0.0171	0.0017	0.0018	0.0146	0.0312	-0.0421	-0.0094	0.017	-0.0128	0.0346	-0.029	0.0118	0.0253	-0.046	-0.0864	0.0714	-0.0331	0.0702	-35.2958	-69.377	150.065
77	0.0053	-0.004	0.003	0.0025	-0.0015	0.0016	0.0027	0.0081	-0.0093	-0.0158	0.0107	-0.0073	0.0056	-0.0106	0.0042	0.1565	-0.0484	-0.0233	0.1593	-0.0756	0.0831	-33.8283	-71.1207	132.1274
78	0.0062	0.0018	0.0101	0.0165	0.021	0.0443	0.0449	0.0028	0.036	0.0615	0.0326	0.0403	0.0398	-0.0099	0.0326	0.1767	-0.0065	0.0472	0.0988	0.0278	0.0992	-42.8011	-47.5751	4.818
79	0.0061	-0.0086	0.0005	0.0154	0.0007	0.0066	0.0085	-0.0049	0.0256	0.0716	0.0187	0.047	-0.0192	-0.011	0.0151	0.1755	-0.0197	0.0849	0.0744	0.0474	0.1263	-45.8209	-39.0736	4.1382
80	0.0022	0.0003	-0.003	0.0002	-0.001	0.0013	-0.0014	-0.0034	-0.0012	0.0031	-0.0023	0.003	0.0023	-0.0094	-0.004	0.166	-0.0499	0.1941	0.1674	0.0761	0.2158	-64.7828	-53.8751	11.6132
81	0.003	-0.0002	-0.0005	-0.0002	0.0013	-0.0002	0.0001	-0.0196	-0.0014	0.0211	0.01	0.0123	-0.0117	-0.0124	0.001	0.2133	0.0056	0.1567	0.1696	0.0191	0.1978	-58.463	-39.3854	14.182
82	0.0016	-0.0024	-0.0024	0.0109	0.0105	0.0083	0.0016	0.0044	-0.0035	0.0317	0.0283	0.0203	0.0173	0.0166	0.0046	0.1195	-0.0249	0.0215	0.094	0.0328	0.1177	-46.19	-60.345	-3.0934
83	0.0026	-0.0021	-0.0066	0.0031	0.0002	0.0125	0.0063	-0.0298	-0.0255	0.0354	-0.0013	-0.0193	0.0174	0.022	-0.0135	0.141	0.0317	-0.1525	0.0593	0.0359	0.0472	-26.755	-70.8021	-2.1865
84	-0.0001	0	0.0004	0.0003	-0.001	0.0011	0.0006	-0.0145	-0.0062	0.0137	0.0122	0.0008	0.0025	0.0129	0	0.3067	0.0116	-0.0687	0.2191	0.0786	0.1185	-30.1786	-72.584	15.5447
85	0.0076	-0.0044	-0.0038	0.02	-0.0176	0.0215	0.0141	-0.001	0.0239	-0.0675	0.0412	-0.0485	0.0166	0.0036	0.0257	0.0959	0.002	0.0067	0.0998	-0.0348	0.1122	-20.8543	-46.5975	-26.9304
86	0.0019	0.0001	-0.0014	0.0012	0.0005	0.0007	-0.0054	0.0032	0.002	-0.0299	0.006	-0.0233	-0.0044	-0.0042	-0.0009	0.1366	0.0079	0.0223	0.0925	-0.029	0.0923	-20.1796	-33.9268	-28.4064
87	0.0024	0.0006	0.0007	0.0025	0.0008	0.0019	-0.0121	-0.0021	0.0109	-0.0096	-0.0108	-0.026	0.0053	0.0171	-0.0181	0.0727	-0.0014	0.0694	0.1056	-0.0898	0.2355	-3.8928	-46.5013	-26.467
88	0.0022	0.0023	-0.004	0.0015	-0.0025	0.0053	0.004	0.0082	0.0104	-0.0166	-0.011	-0.0122	-0.0132	0.0374	-0.0146	0.1484	0.0046	0.1393	0.1402	-0.076	0.2735	0.8516	-45.6945	-34.9704
89	0.0005	-0.0013	-0.0004	-0.0002	-0.0008	0.0003	-0.0001	0.013	-0.0005	-0.0221	0.0128	-0.0134	-0.0125	0.0067	-0	0.2095	-0.0039	0.1023	0.2158	-0.043	0.2594	-1.9743	-41.8634	-36.8852
90	0.0035	0.0013	-0.0011	0.0056	-0.0094	0.015	-0.0066	0.0058	-0.032	-0.0105	0.0253	-0.03	0.0184	-0.0094	0.0115	0.0561	0.0215	0.0024	0.0619	-0.0377	0.1289	-15.6447	-60.0851	-19.8228
91	0.0068	0.0038	-0.0003	0.0031	0.0004	0.0108	-0.0038	0.0403	-0.0317	-0.0316	0.0145	-0.0037	0.0053	-0.036	-0.0051	0.1359	-0.0278	-0.0688	0.0914	-0.0163	0.0652	-34.8498	-71.0332	-21.8315
92	-0	-0.0002	0.0001	0.0003	0	0.0006	-0.0037	0.0117	-0.0097	-0.0138	0.0075	-0.0091	0.0005	-0.0121	0	0.2743	-0.0481	-0.0273	0.2142	-0.0648	0.1167	-31.6512	-70.3926	-39.3689
93	0.0053	-0.0033	0.0053	0.015	0.0067	0.0105	-0.006	0.0028	-0.0068	-0.0365	0.0421	0.042	-0.0142	0.001	0.0201	0.0838	0.0053	0.0075	0.0961	0.0428	0.0992	-42.162	-29.231	143.5359
94	0.0024	0.0013	0.0011	0.0014	-0.0003	0.0007	-0.0049	0.0091	0.0004	-0.0191	0.0178	0.0234	0.0067	0.0064	0	0.1243	0.011	-0.0214	0.0913	0.0264	0.0828	-42.6244	-41.8397	141.8354
95	0.0028	-0.0006	-0.0032	-0.0001	0.0007	0.0103	-0.0169	0.0026	0.0019	-0.0303	-0.0252	0.0424	-0.0173	-0.0242	-0.032	0.0531	0.0465	-0.0904	0.1044	0.1529	0.2654	-62.4544	-26.7205	140.7523
96	0.0007	0.0007	0.001	0.0003	0.0008	0.0008	-0	0.011	-0.0042	-0.0175	-0.0008	0.0072	0.0039	-0.0047	-0	0.2257	-0.0378	-0.1082	0.1809	0.0781	0.195	-56.5118	-40.997	132.1904
97	0.0162	-0.0044	-0.012	0.0022	0.0016	0.0272	0.0287	0.0032	0.0169	-0.013	0.0333	0.0517	-0.0094	-0.0036	0.0167	0.087	0.0249	0.0036	0.1219	0.0724	0.2151	-53.6393	-19.3639	146.7788
98	0.0081	0.0007	0.0087	0.0143	-0.0012	0.0057	-0.0105	0.0547	0.0332	-0.0128	0.0341	0.0149	-0.0377	0.05	-0.0004	0.0967	-0.0043	0.0501	0.1072	0.0274	0.1034	-28.7568	-6.6941	149.0008
99	-0	0.0001	-0.0002	0.0007	-0.0009	0.0008	-0.0024	0.0094	0.002	-0.0142	0.0154	0.004	-0.0087	0.0123	-0	0.2161	-0.0337	0.0206	0.1888	0.0963	0.1447	-31.4827	-5.3918	130.9328
100	0.0213	0.0013	-0.009	0.0355	-0.0214	0.0214	0.0776	-0.0244	-0.0474	0.115	0.0345	-0.0499	0.0148	0.029	0.0653	0.1644	-0.0391	-0.0364	0.0809	-0.0298	0.0721	-17.793	-33.4518	174.4411
101	0.0061	0.0009	0.0048	0.0005	0.0015	0.0021	0.0061	-0.009	-0.0079	0.0062	-0.0048	-0.0102	-0.0049	0.0097	-0.0022	0.1456	-0.0812	-0.1338	0.1609	-0.0875	0.1832	2.6584	-22.2957	181.0162
102	0.002	-0.0001	0.002	-0.0001	-0.0008	0.0006	0.0067	-0.0266	-0.0038	0.0144	0.0127	-0.016	0.0123	0.0089	0.0056	0.1727	-0.0218	-0.13	0.1648	-0.0326	0.1428	-3.287	-36.8786	183.5181
103	0.0022	-0.0009	-0.0014	0.0037	-0.0009	0.0124	0.0125	0.0034	0.0123	0.0182	0.0182	-0.0103	-0.011	-0.0068	0.0071	0.1244	-0.0312	0.0191	0.0956	-0.0325	0.1033	-16.26	-15.6085	166.9976
104	0.0218	-0.0046	0.0045	0.0008	-0.0023	0.0185	-0.0093	-0.046	0.0324	0.0179	-0.0065	0.0166	-0.0042	-0.0256	-0.0243	0.1473	0.0403	0.1522	0.0718	-0.038	0.0864	-35.477	-4.7075	169.1479
105	0.0002	0.0011	-0.0014	0.0028	-0.0032	0.0042	-0.0041	-0.0077	0.0038	0.0167	0.0148	-0.0058	0.0016	-0.0133	0.0058	0.2288	0.0005	0.0708	0.1868	-0.077	0.1083	-31.7718	-4.8144	186.7528
106	0.0016	-0.0045	-0.0033	0.0271	0.0239	0.0246	0.0344	-0.0051	-0.0362	-0.0709	0.042	0.0343	-0.0156	-0.0098	0.0416	0.1646	0.0178	-0.0363	0.0709	0.0384	0.0789	5.4164	-99.5511	15.4004
107	0.0009	0.0006	0.0009	0.0004	0	0.0003	0.002	-0.0015	-0.0111	-0.032	-0.0031	0.0086	0.0029	-0.0003	-0.0004	0.1829	0.0238	-0.0587	0.0729	0.0281	0.0862	4.7174	-112.2688	14.3574
108	0.0004	0.0001	0.0003	0.003	-0.0004	0.001	0.0018	-0	-0.0077	-0.0058	0.0041	0.0127	0.0048	-0.0096	-0.0019	0.1615	-0.0018	-0.0936	0.126	0.0656	0.1844	-9.4791	-103.7899	18.8617
109	0.0028	-0.0002	0.004	0.0005	-0.0011	0.0018	0.0032	0.0037	-0.0044	-0.0019	-0.001	0.0031	-0.0051	-0.0154	-0.0006	0.1765	0.0427	-0.1889	0.1423	0.0693	0.2116	-17.9238	-93.21	7.4266
110	0.0004	0.0004	0.0006	0.0002	0.0004	0.0004	-0.0065	0.0102	-0.0055	-0.0084	0.002	0.0034	0.0048	-0.0029	-0	0.25	-0.0112	-0.1104	0.1738	0.0166	0.2146	-8.4845	-111.4517	3.6391
111	0.001	-0	0.0012	0.0012	-0.0014	0.0014	0.0195	-0.0013	-0.0085	-0.0173	0.0084	0.0242	-0.0036	-0.0011	0.0054	0.1654	0.0082	-0.0912	0.1519	0.0594	0.21	-11.6281	-94.6032	15.0132
112	0.002	-0.0002	0.0006	0.0015	-0.0003	-0.0003	0.0063	-0.003	0.0044	-0.0143	0.0124	0.0027	-0.0117	0.0067	0	0.1795	0.0218	-0.0087	0.1324	0.0468	0.1427	1.509	-82.7446	22.1525
113	0.0029	-0.0011	0.0044	0.0092	-0.0021	0.002	0.0313	0.0135	0.0265	-0.026	0.0178	-0.0044	-0.0331	0.015	0.0176	0.1194	-0.0036	0.0695	0.0948	0.0053	0.1195	18.2596	-78.3408	26.1862
114	0.004	-0.0002	-0.005	-0.0001	0.0001	0.0064	0.0022	0.0119	0.0135	-0.015	0.0087	-0.0006	-0.0004	0.0186	0.0067	0.1935	-0.0025	0.112	0.1318	0.0482	0.0866	19.1339	-74.9532	14.0798
115	0.0011	0.0016	0.0008	0.01	0.0059	0.0039	0.0017	0.0075	0.0058	-0.0112	0.0093	0.003	0.003	0.013	0.0008	0.2658	0.0066	0.0637	0.1823	0.0757	0.0849	16.8546	-75.9218	3.2609
116	0.0088	-0.0051	0.004	0.0225	-0.0178	0.0159	0.0183	0.0117	-0.0155	0.0559	0.0355	-0.0638	-0.0135	0.0111	0.0311	0.0697	-0.006	-0.0085	0.069	-0.0359	0.0891	24.5566	-101.2453	46.0431
117	-0.0001	0.0002	-0.0001	0.0009	-0.0007	0.0005	-0.0083	-0.0095	-0.0034	0.0071	-0.003	0.0005	0.0052	-0.0063	0	0.2389	-0.0232	-0.0467	0.1904	-0.0151	0.1585	25.837	-111.791	57.4534
118	0.0056	-0	-0.0034	-0.0004	0.0004	0.0046	-0.0133	-0.0099	-0.0074	0.02	-0.021	-0.0174	-0.0137	0.0227	-0.0249	0.0597	-0.033	-0.1326	0.1211	-0.1451	0.2704	45.1087	-96.3636	51.381
119	0.0003	-0.0003	0.0005	0.0001	-0.0003	0.0004	0.0003	-0.0131	-0.001	0.011	-0.0044	-0.0044	0.0016	0.0037	-0	0.2019	0.0336	-0.0967	0.1742	-0.0471	0.2025	38.2833	-110.2289	60.2133
120	0.0605	0.0248	-0.0266	0.0117	-0.0034	0.158	0.0541	0.0063	0.0041	0.0248	0.0611	-0.0716	-0.0496	-0.0235	0.0763	0.0534	-0.0157	-0.002	0.0633	-0.0411	0.1677	27.0707	-85.2994	40.5093
121	0.0117	-0.0019	-0.005	0.002	-0.0016	0.008	-0.0022	-0.0215	0.0159	0.0134	-0.0017	-0.0003	-0.009	-0.0186	-0.006	0.1113	0.0404	0.105	0.0846	-0.0482	0.0823	11.2105	-75.0242	45.6731
122	-0	0	-0.0003	0.0007	0.0011	0.0009	0.0063	-0.0124	0.0035	0.0123	0.0167	-0.0015	-0.0064	-0.0122	-0	0.248	0.0319	0.0451	0.1907	-0.0692	0.134	13.4615	-74.7638	58.7032
123	0.0037	-0.0037	0.0004	0.0226	0.0073	0.0118	0.0417	0.026	-0.0358	-0.0471	0.0393	0.0372	0.0074	0.0034	0.0424	0.0669	0.0121	-0.0064	0.0879	0.0137	0.0677	6.6199	-101.0912	101.9768
124	-0	-0.0001	-0.0003	0.0003	0.0006	0.0004	-0.0051	0.0125	-0.012	-0.0124	-0.0019	0.0009	0.0075	0.0103	-0.0024	0.1833	0.0441	-0.0535	0.1433	-0.0144	0.116	5.4097	-112.1293	93.3822
125	0.0156	0.0067	-0.0034	0.0029	-0.0005	0.0064	0.0105	0.0325	-0.0141	-0.0397	0.0049	0.0587	0.0155	-0.0433	-0.003	0.0336	0.0543	-0.1795	0.0527	0.0822	0.1341	-12.8038	-99.8248	95.0945
126	0.0015	-0.0002	-0.0012	0.0001	0.0022	0.0041	0.0062	0.015	0.0005	-0.0228	0.0106	0.0237	0.0111	-0.0024	0.0029	0.1552	0.0074	-0.0986	0.1703	0.0432	0.1501	-11.3457	-104.1085	88.3479
127	0.0035	-0.0019	0.0011	0.0026	0.0002	0	0.0134	0.0074	0.0223	0.0064	0.0012	0.019	-0.0032	0.0063	0	0.088	0.0052	-0.0048	0.1191	0.0357	0.1255	-1.2527	-84.4168	106.7461
128	0.0086	0.0033	0.0135	0.0216	-0.0052	0.0146	0.0299	0.0468	0.0562	-0.0245	0.0307	-0.0098	-0.0208	0.0218	0.0155	0.0587	-0.0109	0.0502	0.0889	0.0128	0.0952	19.2652	-76.8077	107.1888
129	0.0028	-0.0027	-0.0024	0.002	0.0013	0.0017	-0.0006	0.0052	0.003	-0.0169	0.0098	0.0008	-0.0094	0.0131	0.0021	0.1559	-0.0177	0.0444	0.1644	0.0774	0.0691	18.0233	-75.258	89.1705
130	0.022	0.0043	-0.0085	0.0443	-0.0272	0.0228	0.0754	-0.0176	-0.0378	0.0605	0.0467	-0.0281	0.0053	0.0099	0.0803	0.0743	-0.024	-0.0256	0.0778	-0.0208	0.0534	24.4752	-101.5638	131.5515
131	-0.0002	0.0002	0.0002	0.0026	-0.0022	0.0008	0.02	-0.0195	-0.0225	0.0282	0.0143	-0.0178	0.0276	-0.0003	0.0138	0.1189	-0.0364	-0.0799	0.089	-0.0109	0.0691	29.9902	-108.3435	138.443
132	0.0059	0.0019	0.0078	0.0001	0.0033	0.0077	0.0074	-0.0188	-0.0102	0.0169	-0.0151	-0.0206	-0.0085	0.0235	-0.011	0.0685	-0.054	-0.1562	0.1079	-0.0818	0.2007	47.5618	-95.1682	138.8194
133	0.0002	-0.0007	-0.0002	-0.0004	-0.0011	-0.0002	0.0201	-0.0249	-0.01	0.0322	0.0164	-0.0303	0.0269	0.0041	0.0155	0.1676	0.0103	-0.124	0.1277	-0.0151	0.147	41.5277	-107.358	143.5457
134	0.0023	-0.0032	0.001	0.0096	-0.0037	0.0009	0.0162	-0.0046	0.0233	-0.0087	0.0229	-0.0109	0.0003	-0.0096	0.0077	0.0567	-0.0197	-0.0032	0.0821	-0.0199	0.0945	30.2039	-86.0303	126.0207
135	0.0039	-0.0001	0.0052	0.0093	-0.0055	0.015	0.0048	-0.048	0.0429	0.0149	0.0045	0.0083	-0.0177	-0.0209	-0.0056	0.0412	0.0248	0.0832	0.075	-0.0384	0.0907	10.7989	-75.0683	126.6922
136	0.002	0.0025	-0.0026	0.0026	-0.0024	0.003	0.0014	-0.0096	0.0055	0.0165	0.0157	0.0003	-0.0086	-0.0148	0.0056	0.1676	0.0124	0.0462	0.1786	-0.0834	0.1014	13.0209	-75.2608	144.4118
137	0.0018	-0.0008	0.0022	0.0331	-0.0213	0.0163	0.058	0.0058	-0.0403	0.0893	0.0371	-0.0367	-0.0211	0.0291	0.0389	0.1809	-0.0181	-0.0361	0.0696	-0.0278	0.0763	-21.4383	-31.3116	3.7556
138	0.0028	-0.0027	-0.0016	0.0045	0.0012	0.0017	0.0007	-0.0145	-0.0083	0.0146	0.0098	-0.014	0.0192	-0.0036	0.0005	0.1919	-0.0232	-0.0933	0.0808	-0.0579	0.1045	-15.8744	-38.9787	8.5965
139	0.0034	-0.0014	0.0054	0.0006	-0.0004	0.0042	0.0002	-0.0118	-0.0062	0.0033	-0.0111	-0.0039	-0.0079	0.0212	-0.013	0.1649	-0.0522	-0.1785	0.1332	-0.0915	0.21	1.5661	-25.4877	10.6616
140	0.0012	0.0001	0.0007	-0.0003	-0.0009	-0	0.0065	-0.015	0.0025	0.0224	0.0161	-0.0159	0.0209	0.0137	0.0003	0.2363	0.0036	-0.1443	0.1611	-0.0361	0.2168	-3.887	-37.8469	14.9792
141	0.001	-0.0001	0.0008	0.0045	-0.004	0.0029	0.0097	-0.0007	0.0083	0.032	0.0274	-0.0297	-0.016	-0.0084	0.0005	0.1315	-0.0186	-0.0205	0.0787	-0.0304	0.119	-16.0495	-16.0622	-1.6474
142	0.0055	-0.0022	0.0003	0.01	0.0063	0.0101	0.0139	-0.0213	0.033	0.0439	-0.0031	0.0201	-0.0113	-0.0225	-0.0043	0.1507	0.0159	0.1714	0.0723	-0.0372	0.0711	-35.3524	-5.2243	-0.0502
143	0.001	0.0027	-0.003	0.0038	-0.0047	0.0062	-0.001	-0.0082	0.0073	0.0127	0.0088	-0.0018	0.0024	-0.0107	0.0071	0.2227	-0.014	0.0632	0.1612	-0.0625	0.0773	-32.6443	-5.871	17.5968
144	0.0093	-0.0063	-0.0009	0.0087	0.0079	0.0142	0.0154	0.0039	-0.0226	-0.0354	0.0269	0.0466	-0.0233	-0.0124	0.0218	0.0935	-0.0068	-0.0288	0.0814	0.0467	0.1176	-42.2022	-28.5411	-27.0926
145	0.0021	0.0014	0.0001	0.0064	-0.0016	0.0028	0.011	-0.0012	-0.0041	-0.0303	0.0182	0.0176	0.0101	0.0019	0.0083	0.1181	0.003	-0.035	0.0971	0.0189	0.0884	-39.1047	-39.2784	-27.8768
146	0.0027	-0.0008	-0.0001	-0.001	-0.0012	0.001	-0.0041	0.0073	0.0021	-0.022	-0.0161	0.0269	-0.0089	-0.0209	-0.0214	0.0206	0.0423	-0.1599	0.0843	0.1483	0.2408	-60.9009	-26.3688	-30.6716
147	0.001	0.0004	0.0003	0.0001	0.0001	0.0002	-0.004	0.0147	-0.0027	-0.0125	-0.0025	0.0055	0.0011	-0.0012	0	0.222	-0.0356	-0.116	0.1803	0.0598	0.2123	-53.8018	-40.3458	-39.5893
148	0.0015	-0.0016	0.0021	0.0014	-0.0017	0.0015	0.0294	0.0069	0.0061	-0.0106	0.0191	0.0274	-0.0066	-0.0064	-0	0.1096	-0.0008	-0.0528	0.1578	0.0795	0.2359	-57.5983	-24.0287	-27.1591
149	0.0013	0.0001	-0.0001	0.0006	0.0001	-0.0003	-0.0076	-0.0093	0.0094	-0.0055	0.0079	0.0149	-0.0069	0.007	0	0.1248	0.0038	0.003	0.1247	0.0423	0.185	-44.7106	-12.3477	-19.3505
150	0.0152	-0.001	0.009	0.0272	-0.0164	0.0103	0.03	0.0353	0.0391	-0.0337	0.0519	0.0023	-0.0512	0.026	0.0355	0.1074	-0.0296	0.0767	0.094	-0.0004	0.0913	-27.5721	-6.4967	-19.9214
151	0.0037	0.0014	0.0007	0.0078	0.0051	0.0039	0.0036	0.0117	0.0068	-0.0167	0.0197	0.0065	-0.0044	0.0091	0.0029	0.22	-0.0372	0.0396	0.16	0.066	0.0901	-29.2967	-4.6208	-37.9005

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	CHAIN 'A' AND (RESID 7 THROUGH 71 )
2	X-RAY DIFFRACTION	2	CHAIN 'A' AND (RESID 72 THROUGH 153 )
3	X-RAY DIFFRACTION	3	CHAIN 'A' AND (RESID 154 THROUGH 209 )
4	X-RAY DIFFRACTION	4	CHAIN 'A' AND (RESID 210 THROUGH 256 )
5	X-RAY DIFFRACTION	5	CHAIN 'A' AND (RESID 257 THROUGH 305 )
6	X-RAY DIFFRACTION	6	CHAIN 'A' AND (RESID 306 THROUGH 419 )
7	X-RAY DIFFRACTION	7	CHAIN 'B' AND (RESID 7 THROUGH 91 )
8	X-RAY DIFFRACTION	8	CHAIN 'B' AND (RESID 92 THROUGH 125 )
9	X-RAY DIFFRACTION	9	CHAIN 'B' AND (RESID 126 THROUGH 209 )
10	X-RAY DIFFRACTION	10	CHAIN 'B' AND (RESID 210 THROUGH 256 )
11	X-RAY DIFFRACTION	11	CHAIN 'B' AND (RESID 257 THROUGH 332 )
12	X-RAY DIFFRACTION	12	CHAIN 'B' AND (RESID 333 THROUGH 393 )
13	X-RAY DIFFRACTION	13	CHAIN 'B' AND (RESID 394 THROUGH 421 )
14	X-RAY DIFFRACTION	14	CHAIN 'C' AND (RESID 7 THROUGH 96 )
15	X-RAY DIFFRACTION	15	CHAIN 'C' AND (RESID 97 THROUGH 125 )
16	X-RAY DIFFRACTION	16	CHAIN 'C' AND (RESID 126 THROUGH 172 )
17	X-RAY DIFFRACTION	17	CHAIN 'C' AND (RESID 173 THROUGH 226 )
18	X-RAY DIFFRACTION	18	CHAIN 'C' AND (RESID 227 THROUGH 256 )
19	X-RAY DIFFRACTION	19	CHAIN 'C' AND (RESID 257 THROUGH 305 )
20	X-RAY DIFFRACTION	20	CHAIN 'C' AND (RESID 306 THROUGH 393 )
21	X-RAY DIFFRACTION	21	CHAIN 'C' AND (RESID 394 THROUGH 421 )
22	X-RAY DIFFRACTION	22	CHAIN 'D' AND (RESID 7 THROUGH 71 )
23	X-RAY DIFFRACTION	23	CHAIN 'D' AND (RESID 72 THROUGH 110 )
24	X-RAY DIFFRACTION	24	CHAIN 'D' AND (RESID 111 THROUGH 172 )
25	X-RAY DIFFRACTION	25	CHAIN 'D' AND (RESID 173 THROUGH 201 )
26	X-RAY DIFFRACTION	26	CHAIN 'D' AND (RESID 202 THROUGH 226 )
27	X-RAY DIFFRACTION	27	CHAIN 'D' AND (RESID 227 THROUGH 255 )
28	X-RAY DIFFRACTION	28	CHAIN 'D' AND (RESID 256 THROUGH 298 )
29	X-RAY DIFFRACTION	29	CHAIN 'D' AND (RESID 299 THROUGH 340 )
30	X-RAY DIFFRACTION	30	CHAIN 'D' AND (RESID 341 THROUGH 393 )
31	X-RAY DIFFRACTION	31	CHAIN 'D' AND (RESID 394 THROUGH 421 )
32	X-RAY DIFFRACTION	32	CHAIN 'E' AND (RESID 7 THROUGH 97 )
33	X-RAY DIFFRACTION	33	CHAIN 'E' AND (RESID 98 THROUGH 125 )
34	X-RAY DIFFRACTION	34	CHAIN 'E' AND (RESID 126 THROUGH 226 )
35	X-RAY DIFFRACTION	35	CHAIN 'E' AND (RESID 227 THROUGH 305 )
36	X-RAY DIFFRACTION	36	CHAIN 'E' AND (RESID 306 THROUGH 393 )
37	X-RAY DIFFRACTION	37	CHAIN 'E' AND (RESID 394 THROUGH 421 )
38	X-RAY DIFFRACTION	38	CHAIN 'F' AND (RESID 7 THROUGH 81 )
39	X-RAY DIFFRACTION	39	CHAIN 'F' AND (RESID 82 THROUGH 112 )
40	X-RAY DIFFRACTION	40	CHAIN 'F' AND (RESID 113 THROUGH 153 )
41	X-RAY DIFFRACTION	41	CHAIN 'F' AND (RESID 154 THROUGH 209 )
42	X-RAY DIFFRACTION	42	CHAIN 'F' AND (RESID 210 THROUGH 256 )
43	X-RAY DIFFRACTION	43	CHAIN 'F' AND (RESID 257 THROUGH 305 )
44	X-RAY DIFFRACTION	44	CHAIN 'F' AND (RESID 306 THROUGH 393 )
45	X-RAY DIFFRACTION	45	CHAIN 'F' AND (RESID 394 THROUGH 421 )
46	X-RAY DIFFRACTION	46	CHAIN 'G' AND (RESID 7 THROUGH 81 )
47	X-RAY DIFFRACTION	47	CHAIN 'G' AND (RESID 82 THROUGH 125 )
48	X-RAY DIFFRACTION	48	CHAIN 'G' AND (RESID 126 THROUGH 172 )
49	X-RAY DIFFRACTION	49	CHAIN 'G' AND (RESID 173 THROUGH 201 )
50	X-RAY DIFFRACTION	50	CHAIN 'G' AND (RESID 202 THROUGH 226 )
51	X-RAY DIFFRACTION	51	CHAIN 'G' AND (RESID 227 THROUGH 256 )
52	X-RAY DIFFRACTION	52	CHAIN 'G' AND (RESID 257 THROUGH 305 )
53	X-RAY DIFFRACTION	53	CHAIN 'G' AND (RESID 306 THROUGH 393 )
54	X-RAY DIFFRACTION	54	CHAIN 'G' AND (RESID 394 THROUGH 421 )
55	X-RAY DIFFRACTION	55	CHAIN 'H' AND (RESID 7 THROUGH 81 )
56	X-RAY DIFFRACTION	56	CHAIN 'H' AND (RESID 82 THROUGH 125 )
57	X-RAY DIFFRACTION	57	CHAIN 'H' AND (RESID 126 THROUGH 209 )
58	X-RAY DIFFRACTION	58	CHAIN 'H' AND (RESID 210 THROUGH 237 )
59	X-RAY DIFFRACTION	59	CHAIN 'H' AND (RESID 238 THROUGH 273 )
60	X-RAY DIFFRACTION	60	CHAIN 'H' AND (RESID 274 THROUGH 298 )
61	X-RAY DIFFRACTION	61	CHAIN 'H' AND (RESID 299 THROUGH 393 )
62	X-RAY DIFFRACTION	62	CHAIN 'H' AND (RESID 394 THROUGH 421 )
63	X-RAY DIFFRACTION	63	CHAIN 'I' AND (RESID 7 THROUGH 96 )
64	X-RAY DIFFRACTION	64	CHAIN 'I' AND (RESID 97 THROUGH 142 )
65	X-RAY DIFFRACTION	65	CHAIN 'I' AND (RESID 143 THROUGH 209 )
66	X-RAY DIFFRACTION	66	CHAIN 'I' AND (RESID 210 THROUGH 256 )
67	X-RAY DIFFRACTION	67	CHAIN 'I' AND (RESID 257 THROUGH 305 )
68	X-RAY DIFFRACTION	68	CHAIN 'I' AND (RESID 306 THROUGH 393 )
69	X-RAY DIFFRACTION	69	CHAIN 'I' AND (RESID 394 THROUGH 421 )
70	X-RAY DIFFRACTION	70	CHAIN 'J' AND (RESID 7 THROUGH 81 )
71	X-RAY DIFFRACTION	71	CHAIN 'J' AND (RESID 82 THROUGH 110 )
72	X-RAY DIFFRACTION	72	CHAIN 'J' AND (RESID 111 THROUGH 172 )
73	X-RAY DIFFRACTION	73	CHAIN 'J' AND (RESID 173 THROUGH 225 )
74	X-RAY DIFFRACTION	74	CHAIN 'J' AND (RESID 226 THROUGH 255 )
75	X-RAY DIFFRACTION	75	CHAIN 'J' AND (RESID 256 THROUGH 298 )
76	X-RAY DIFFRACTION	76	CHAIN 'J' AND (RESID 299 THROUGH 393 )
77	X-RAY DIFFRACTION	77	CHAIN 'J' AND (RESID 394 THROUGH 421 )
78	X-RAY DIFFRACTION	78	CHAIN 'K' AND (RESID 7 THROUGH 71 )
79	X-RAY DIFFRACTION	79	CHAIN 'K' AND (RESID 72 THROUGH 153 )
80	X-RAY DIFFRACTION	80	CHAIN 'K' AND (RESID 154 THROUGH 209 )
81	X-RAY DIFFRACTION	81	CHAIN 'K' AND (RESID 210 THROUGH 256 )
82	X-RAY DIFFRACTION	82	CHAIN 'K' AND (RESID 257 THROUGH 305 )
83	X-RAY DIFFRACTION	83	CHAIN 'K' AND (RESID 306 THROUGH 388 )
84	X-RAY DIFFRACTION	84	CHAIN 'K' AND (RESID 389 THROUGH 421 )
85	X-RAY DIFFRACTION	85	CHAIN 'L' AND (RESID 7 THROUGH 81 )
86	X-RAY DIFFRACTION	86	CHAIN 'L' AND (RESID 82 THROUGH 125 )
87	X-RAY DIFFRACTION	87	CHAIN 'L' AND (RESID 126 THROUGH 172 )
88	X-RAY DIFFRACTION	88	CHAIN 'L' AND (RESID 173 THROUGH 226 )
89	X-RAY DIFFRACTION	89	CHAIN 'L' AND (RESID 227 THROUGH 256 )
90	X-RAY DIFFRACTION	90	CHAIN 'L' AND (RESID 257 THROUGH 305 )
91	X-RAY DIFFRACTION	91	CHAIN 'L' AND (RESID 306 THROUGH 393 )
92	X-RAY DIFFRACTION	92	CHAIN 'L' AND (RESID 394 THROUGH 421 )
93	X-RAY DIFFRACTION	93	CHAIN 'M' AND (RESID 7 THROUGH 81 )
94	X-RAY DIFFRACTION	94	CHAIN 'M' AND (RESID 82 THROUGH 125 )
95	X-RAY DIFFRACTION	95	CHAIN 'M' AND (RESID 126 THROUGH 209 )
96	X-RAY DIFFRACTION	96	CHAIN 'M' AND (RESID 210 THROUGH 237 )
97	X-RAY DIFFRACTION	97	CHAIN 'M' AND (RESID 238 THROUGH 298 )
98	X-RAY DIFFRACTION	98	CHAIN 'M' AND (RESID 299 THROUGH 393 )
99	X-RAY DIFFRACTION	99	CHAIN 'M' AND (RESID 394 THROUGH 421 )
100	X-RAY DIFFRACTION	100	CHAIN 'N' AND (RESID 7 THROUGH 153 )
101	X-RAY DIFFRACTION	101	CHAIN 'N' AND (RESID 154 THROUGH 209 )
102	X-RAY DIFFRACTION	102	CHAIN 'N' AND (RESID 210 THROUGH 256 )
103	X-RAY DIFFRACTION	103	CHAIN 'N' AND (RESID 257 THROUGH 305 )
104	X-RAY DIFFRACTION	104	CHAIN 'N' AND (RESID 306 THROUGH 393 )
105	X-RAY DIFFRACTION	105	CHAIN 'N' AND (RESID 394 THROUGH 421 )
106	X-RAY DIFFRACTION	106	CHAIN 'O' AND (RESID 7 THROUGH 81 )
107	X-RAY DIFFRACTION	107	CHAIN 'O' AND (RESID 82 THROUGH 125 )
108	X-RAY DIFFRACTION	108	CHAIN 'O' AND (RESID 126 THROUGH 153 )
109	X-RAY DIFFRACTION	109	CHAIN 'O' AND (RESID 154 THROUGH 209 )
110	X-RAY DIFFRACTION	110	CHAIN 'O' AND (RESID 210 THROUGH 237 )
111	X-RAY DIFFRACTION	111	CHAIN 'O' AND (RESID 238 THROUGH 273 )
112	X-RAY DIFFRACTION	112	CHAIN 'O' AND (RESID 274 THROUGH 298 )
113	X-RAY DIFFRACTION	113	CHAIN 'O' AND (RESID 299 THROUGH 354 )
114	X-RAY DIFFRACTION	114	CHAIN 'O' AND (RESID 355 THROUGH 393 )
115	X-RAY DIFFRACTION	115	CHAIN 'O' AND (RESID 394 THROUGH 421 )
116	X-RAY DIFFRACTION	116	CHAIN 'P' AND (RESID 7 THROUGH 96 )
117	X-RAY DIFFRACTION	117	CHAIN 'P' AND (RESID 97 THROUGH 125 )
118	X-RAY DIFFRACTION	118	CHAIN 'P' AND (RESID 126 THROUGH 209 )
119	X-RAY DIFFRACTION	119	CHAIN 'P' AND (RESID 210 THROUGH 237 )
120	X-RAY DIFFRACTION	120	CHAIN 'P' AND (RESID 238 THROUGH 340 )
121	X-RAY DIFFRACTION	121	CHAIN 'P' AND (RESID 341 THROUGH 393 )
122	X-RAY DIFFRACTION	122	CHAIN 'P' AND (RESID 394 THROUGH 421 )
123	X-RAY DIFFRACTION	123	CHAIN 'Q' AND (RESID 7 THROUGH 91 )
124	X-RAY DIFFRACTION	124	CHAIN 'Q' AND (RESID 92 THROUGH 125 )
125	X-RAY DIFFRACTION	125	CHAIN 'Q' AND (RESID 126 THROUGH 226 )
126	X-RAY DIFFRACTION	126	CHAIN 'Q' AND (RESID 227 THROUGH 255 )
127	X-RAY DIFFRACTION	127	CHAIN 'Q' AND (RESID 256 THROUGH 298 )
128	X-RAY DIFFRACTION	128	CHAIN 'Q' AND (RESID 299 THROUGH 393 )
129	X-RAY DIFFRACTION	129	CHAIN 'Q' AND (RESID 394 THROUGH 421 )
130	X-RAY DIFFRACTION	130	CHAIN 'R' AND (RESID 7 THROUGH 96 )
131	X-RAY DIFFRACTION	131	CHAIN 'R' AND (RESID 97 THROUGH 142 )
132	X-RAY DIFFRACTION	132	CHAIN 'R' AND (RESID 143 THROUGH 209 )
133	X-RAY DIFFRACTION	133	CHAIN 'R' AND (RESID 210 THROUGH 256 )
134	X-RAY DIFFRACTION	134	CHAIN 'R' AND (RESID 257 THROUGH 305 )
135	X-RAY DIFFRACTION	135	CHAIN 'R' AND (RESID 306 THROUGH 393 )
136	X-RAY DIFFRACTION	136	CHAIN 'R' AND (RESID 394 THROUGH 421 )
137	X-RAY DIFFRACTION	137	CHAIN 'Z' AND (RESID 7 THROUGH 91 )
138	X-RAY DIFFRACTION	138	CHAIN 'Z' AND (RESID 92 THROUGH 142 )
139	X-RAY DIFFRACTION	139	CHAIN 'Z' AND (RESID 143 THROUGH 209 )
140	X-RAY DIFFRACTION	140	CHAIN 'Z' AND (RESID 210 THROUGH 256 )
141	X-RAY DIFFRACTION	141	CHAIN 'Z' AND (RESID 257 THROUGH 305 )
142	X-RAY DIFFRACTION	142	CHAIN 'Z' AND (RESID 306 THROUGH 393 )
143	X-RAY DIFFRACTION	143	CHAIN 'Z' AND (RESID 394 THROUGH 421 )
144	X-RAY DIFFRACTION	144	CHAIN 'T' AND (RESID 7 THROUGH 71 )
145	X-RAY DIFFRACTION	145	CHAIN 'T' AND (RESID 72 THROUGH 125 )
146	X-RAY DIFFRACTION	146	CHAIN 'T' AND (RESID 126 THROUGH 209 )
147	X-RAY DIFFRACTION	147	CHAIN 'T' AND (RESID 210 THROUGH 237 )
148	X-RAY DIFFRACTION	148	CHAIN 'T' AND (RESID 238 THROUGH 273 )
149	X-RAY DIFFRACTION	149	CHAIN 'T' AND (RESID 274 THROUGH 298 )
150	X-RAY DIFFRACTION	150	CHAIN 'T' AND (RESID 299 THROUGH 393 )
151	X-RAY DIFFRACTION	151	CHAIN 'T' AND (RESID 394 THROUGH 421 )