PDB-5vao: Crystal structure of eVP30 C-terminus and eNP peptide

Basic information

• Entry: Database: PDB / ID: 5vao
• Title: Crystal structure of eVP30 C-terminus and eNP peptide

Components

• Minor nucleoprotein VP30
• NP

• Keywords: VIRAL PROTEIN / functional class / known biologyical activity

Function / homology

Function:

viral RNA genome packaging / helical viral capsid / viral nucleocapsid / host cell cytoplasm / ribonucleoprotein complex / RNA binding / zinc ion binding / identical protein binding

Domain/homology:

Four Helix Bundle (Hemerythrin (Met), subunit A) - #1160 / Transcriptional activator VP30, Filoviridae type / Ebola virus-specific transcription factor VP30 / Ebola nucleoprotein / Ebola nucleoprotein / Four Helix Bundle (Hemerythrin (Met), subunit A) / Up-down Bundle / Mainly Alpha

Component:

DI(HYDROXYETHYL)ETHER / Nucleoprotein / Nucleoprotein / Transcriptional activator VP30

• Biological species: Ebola virus
• Method: X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.56 Å
• Authors: XU, W. / Leung, D.W. / Amarasinghe, G.K.
• Citation: Journal: Nat Commun / Year: 2017; Title: Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.; Authors: Xu, W. / Luthra, P. / Wu, C. / Batra, J. / Leung, D.W. / Basler, C.F. / Amarasinghe, G.K.

History

Deposition	Mar 27, 2017	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Jun 21, 2017	Provider: repository / Type: Initial release
Revision 1.1	Mar 6, 2024	Group: Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

Assembly

Deposited unit

A: Minor nucleoprotein VP30

B: Minor nucleoprotein VP30

C: Minor nucleoprotein VP30

D: Minor nucleoprotein VP30

E: NP

F: NP

G: NP

H: NP

hetero molecules

Summary:

• 64.3 kDa, 8 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	64,268	26
Polymers	63,045	8
Non-polymers	1,223	18
Water	2,018	112

1

A: Minor nucleoprotein VP30

F: NP

Summary:

• defined by author&software
• 15.8 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	15,761	2
Polymers	15,761	2
Non-polymers	0	0
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	1330 Å2
ΔGint	-8 kcal/mol
Surface area	8360 Å2
Method	PISA

2

B: Minor nucleoprotein VP30

E: NP

hetero molecules

Summary:

• defined by author&software
• 16.3 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	16,264	9
Polymers	15,761	2
Non-polymers	503	7
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	1250 Å2
ΔGint	-6 kcal/mol
Surface area	8430 Å2
Method	PISA

3

C: Minor nucleoprotein VP30

H: NP

hetero molecules

Summary:

• defined by author&software
• 16 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	15,995	5
Polymers	15,761	2
Non-polymers	234	3
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	1230 Å2
ΔGint	-6 kcal/mol
Surface area	8460 Å2
Method	PISA

4

D: Minor nucleoprotein VP30

G: NP

hetero molecules

Summary:

• defined by author&software
• 16.2 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	16,248	10
Polymers	15,761	2
Non-polymers	486	8
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	1110 Å2
ΔGint	-6 kcal/mol
Surface area	8700 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	139.478, 139.478, 161.467
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	98
Space group name H-M	I4122

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
1	1	A
2	1	B
1	2	A
2	2	C
1	3	A
2	3	D
1	4	B
2	4	C
1	5	B
2	5	D
1	6	C
2	6	D
1	7	E
2	7	F
1	8	E
2	8	G
1	9	E
2	9	H
1	10	F
2	10	G
1	11	F
2	11	H
1	12	G
2	12	H

NCS domain segments:

Component-ID: 0 / Refine code: 0

Dom-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	PRO	PRO	VAL	VAL	A	A	140 - 265	2 - 127
2	1	PRO	PRO	VAL	VAL	B	B	140 - 265	2 - 127
1	2	PRO	PRO	VAL	VAL	A	A	140 - 265	2 - 127
2	2	PRO	PRO	VAL	VAL	C	C	140 - 265	2 - 127
1	3	PRO	PRO	VAL	VAL	A	A	140 - 265	2 - 127
2	3	PRO	PRO	VAL	VAL	D	D	140 - 265	2 - 127
1	4	GLY	GLY	GLN	GLN	B	B	139 - 267	1 - 129
2	4	GLY	GLY	GLN	GLN	C	C	139 - 267	1 - 129
1	5	GLY	GLY	GLN	GLN	B	B	139 - 267	1 - 129
2	5	GLY	GLY	GLN	GLN	D	D	139 - 267	1 - 129
1	6	GLY	GLY	GLN	GLN	C	C	139 - 267	1 - 129
2	6	GLY	GLY	GLN	GLN	D	D	139 - 267	1 - 129
1	7	PRO	PRO	ARG	ARG	E	E	602 - 612	1 - 11
2	7	PRO	PRO	ARG	ARG	F	F	602 - 612	1 - 11
1	8	PRO	PRO	ARG	ARG	E	E	602 - 612	1 - 11
2	8	PRO	PRO	ARG	ARG	G	G	602 - 612	1 - 11
1	9	PRO	PRO	ARG	ARG	E	E	602 - 612	1 - 11
2	9	PRO	PRO	ARG	ARG	H	H	602 - 612	1 - 11
1	10	PRO	PRO	ARG	ARG	F	F	602 - 612	1 - 11
2	10	PRO	PRO	ARG	ARG	G	G	602 - 612	1 - 11
1	11	PRO	PRO	ARG	ARG	F	F	602 - 612	1 - 11
2	11	PRO	PRO	ARG	ARG	H	H	602 - 612	1 - 11
1	12	PRO	PRO	ARG	ARG	G	G	602 - 612	1 - 11
2	12	PRO	PRO	ARG	ARG	H	H	602 - 612	1 - 11

NCS ensembles :

ID
1
2
3
4
5
6
7
8
9
10
11
12

Components

Protein / Protein/peptide , 2 types, 8 molecules A B C D E F G H

#1: Protein

A B C D
Minor nucleoprotein VP30 / Transcription activator VP30

Details:

Mass: 14592.928 Da / Num. of mol.: 4 / Fragment: UNP residues 139-267
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Ebola virus / Gene: VP30 / Plasmid: modified pET15b / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: Q77DJ5

#2: Protein/peptide

E F G H
NP

Details:

Mass: 1168.363 Da / Num. of mol.: 4 / Fragment: UNP residues 601-611
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Ebola virus / Plasmid: modified pET15b / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: A0A0D5W865, UniProt: O72142*PLUS

Non-polymers , 5 types, 130 molecules

#3: Chemical

B-301 B-302 C-301 D-301
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol

Details:

Mass: 92.094 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₃H₈O₃

#4: Chemical

B-303 B-304 B-305 C-302 D-303 D-304 D-305 D-306
ChemComp-CL / CHLORIDE ION / Chloride

Details:

Mass: 35.453 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: Cl

#5: Chemical

B-306 C-303 D-307 D-308 E-701
ChemComp-PEG / DI(HYDROXYETHYL)ETHER / Diethylene glycol

Details:

Mass: 106.120 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: C₄H₁₀O₃

#6: Chemical

D-302 ChemComp-CA / CALCIUM ION

Details:

Mass: 40.078 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Ca

#7: Water

ChemComp-HOH / water / Water

Details:

Mass: 18.015 Da / Num. of mol.: 112 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 3.11 ų/Da / Density % sol: 60.5 %
• Crystal grow: Temperature: 297 K / Method: vapor diffusion / pH: 7 / Details: 0.2 M Calcium chloride dihydrate, 20%w/v PEG3350

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.9792601 Å
• Detector: Type: DECTRIS PILATUS3 S 6M / Detector: PIXEL / Date: Aug 20, 2015
• Radiation: Monochromator: Rosenbaum-Rock high-resolution double-crystal monochromator; Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.9792601 Å / Relative weight: 1
• Reflection: Resolution: 2.55→105.55 Å / Num. obs: 26327 / % possible obs: 99.7 % / Redundancy: 7.6 % / R_merge(I) obs: 0.109 / R_pim(I) all: 0.042 / R_rim(I) all: 0.112 / Χ²: 1.826 / Net I/σ(I): 6.2

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	Rmerge(I) obs	CC1/2	Rpim(I) all	Χ2	% possible all	Rrim(I) all
2.55-2.59	4.3	0.982	0.578	0.497	0.698	94.9
2.59-2.64	5.2	0.939	0.68	0.433	0.757	98.6
2.64-2.69	6.2	0.857	0.744	0.365	1.037	99.9	0.933
2.69-2.75	7.5	0.793	0.816	0.307	0.744	99.9	0.851
2.75-2.81	8	0.722	0.86	0.272	0.73	100	0.772
2.81-2.87	8.1	0.633	0.907	0.237	0.723	100	0.677
2.87-2.94	8.2	0.505	0.93	0.188	0.749	100	0.539
2.94-3.02	8.2	0.448	0.936	0.167	0.769	100	0.478
3.02-3.11	8.2	0.345	0.957	0.129	0.843	100	0.369
3.11-3.21	8.2	0.279	0.974	0.104	0.802	100	0.298
3.21-3.33	8.2	0.207	0.987	0.077	0.817	100	0.221
3.33-3.46	8.1	0.176	0.991	0.066	1.021	100	0.188
3.46-3.62	8.2	0.122	0.995	0.046	0.931	100	0.13
3.62-3.81	8.1	0.104	0.995	0.039	1.125	100	0.111
3.81-4.05	8.1	0.076	0.997	0.029	1.139	100	0.081
4.05-4.36	8	0.064	0.997	0.024	1.379	100	0.069
4.36-4.8	8	0.061	0.998	0.023	1.441	100	0.065
4.8-5.49	7.9	0.064	0.997	0.024	1.951	100	0.068
5.49-6.92	7.7	0.07	0.995	0.027	2.528	100	0.075
6.92-50	7.3	0.053	0.99	0.021	15.204	100	0.057

Processing

Software

Name	Version	Classification
HKL-3000		data scaling
REFMAC	5.8.0158	refinement
PDB_EXTRACT	3.22	data extraction
HKL-3000		data reduction
PHASER		phasing

Refinement

Resolution: 2.56→105.55 Å / Cor.coef. F_o:F_c: 0.94 / Cor.coef. F_o:F_c free: 0.912 / SU B: 18.384 / SU ML: 0.193 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.638 / ESU R Free: 0.286
Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED

	Rfactor	Num. reflection	% reflection	Selection details
Rfree	0.225	1144	5.1 %	RANDOM
Rwork	0.183	-	-	-
obs	0.1851	21271	86.2 %	-

• Solvent computation: Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å

Displacement parameters

B_iso max: 151.38 Ų / B_iso mean: 44.998 Ų / B_iso min: 8.51 Ų

	Baniso -1	Baniso -2	Baniso -3
1-	0.03 Å2	-0 Å2	0 Å2
2-	-	0.03 Å2	-0 Å2
3-	-	-	-0.05 Å2

Refinement step

Cycle: final / Resolution: 2.56→105.55 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	4407	0	68	112	4587
Biso mean	-	-	69.9	33.15	-
Num. residues	-	-	-	-	558

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.008	0.019	4565
X-RAY DIFFRACTION	r_bond_other_d	0.002	0.02	4474
X-RAY DIFFRACTION	r_angle_refined_deg	1.209	1.981	6169
X-RAY DIFFRACTION	r_angle_other_deg	0.914	3	10344
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	4.48	5	554
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	34.888	22.865	185
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	13.492	15	812
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	15.38	15	42
X-RAY DIFFRACTION	r_chiral_restr	0.07	0.2	729
X-RAY DIFFRACTION	r_gen_planes_refined	0.004	0.021	4863
X-RAY DIFFRACTION	r_gen_planes_other	0.001	0.02	903

Refine LS restraints NCS

Refine-ID: X-RAY DIFFRACTION / Type: interatomic distance / Weight position: 0.05

Ens-ID	Dom-ID	Auth asym-ID	Number	Rms dev position (Å)
1	1	A	8008	0.07
1	2	B	8008	0.07
2	1	A	7878	0.09
2	2	C	7878	0.09
3	1	A	7898	0.08
3	2	D	7898	0.08
4	1	B	8066	0.08
4	2	C	8066	0.08
5	1	B	8114	0.07
5	2	D	8114	0.07
6	1	C	8030	0.09
6	2	D	8030	0.09
7	1	E	418	0.17
7	2	F	418	0.17
8	1	E	424	0.07
8	2	G	424	0.07
9	1	E	428	0.11
9	2	H	428	0.11
10	1	F	418	0.19
10	2	G	418	0.19
11	1	F	418	0.17
11	2	H	418	0.17
12	1	G	432	0.09
12	2	H	432	0.09

LS refinement shell

Resolution: 2.558→2.625 Å / R_factor R_free error: 0 / Total num. of bins used: 20

	Rfactor	Num. reflection	% reflection
Rfree	0.214	10	-
Rwork	0.353	95	-
all	-	105	-
obs	-	-	5.6 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	5.969	2.3576	-0.5243	1.4808	-1.4351	3.5388	-0.3779	0.4725	0.2043	-0.0418	0.0827	-0.006	0.525	0.0592	0.2952	0.7119	-0.0703	0.0752	0.1191	-0.0641	0.2001	-30.9187	-40.7071	-47.8286
2	9.0812	-1.569	-2.9559	3.7475	2.2693	2.0771	-0.2336	-0.078	-0.2434	-0.048	-0.0346	0.0225	0.0388	0.0226	0.2682	0.1341	0.0071	-0.0229	0.1207	-0.0246	0.2115	-22.4089	-39.1014	-45.0214
3	7.057	0.131	-1.8289	2.433	0.4678	0.5777	-0.2256	-0.1683	-0.1101	-0.1281	0.2113	-0.0892	0.0322	0.0849	0.0143	0.1297	0.0227	-0.0259	0.1536	-0.042	0.1531	-15.8675	-34.2866	-45.7668
4	0.599	-0.9652	1.8085	2.4609	-1.3994	8.0343	-0.0207	-0.047	0.0479	-0.1239	0.0642	-0.2202	-0.33	-0.2321	-0.0435	0.1519	-0.0459	-0.0289	0.204	-0.044	0.1232	-13.1209	-27.3114	-51.9891
5	0.4349	1.5811	-0.7389	10.3729	-0.1077	2.695	-0.1045	0.0214	-0.0663	-0.1959	0.0065	-0.2858	0.2664	-0.0724	0.0981	0.1583	0.0024	-0.082	0.1925	-0.0086	0.0839	-21.5296	-27.0918	-55.7376
6	3.2521	-0.5879	-4.7548	1.5055	2.3732	8.5901	-0.0979	0.2868	0.2097	0.0386	0.1038	0.2209	0.1768	-0.2701	-0.0059	0.1462	-0.0036	-0.1042	0.1622	-0.0147	0.1928	-28.8466	-28.2384	-46.9531
7	2.301	1.1596	-2.1402	1.1357	0.4859	6.4315	0.3053	-0.0021	0.1588	0.2629	-0.1565	0.0843	0.035	-0.4319	-0.1488	0.1202	-0.0203	-0.0521	0.1647	-0.0466	0.1537	-34.6499	-26.767	-36.316
8	6.4641	-6.3397	2.1558	11.1023	3.2751	6.6662	-0.103	0.0829	-0.05	0.3847	-0.1894	0.3264	0.2579	-0.1025	0.2924	0.0838	0.0163	0.0071	0.1487	-0.0664	0.2105	-26.8432	-22.8139	-31.9435
9	8.5182	-2.0669	3.643	10.6739	6.4409	6.8498	0.4192	0.0869	0.0022	0.1026	-0.3376	0.025	0.3415	-0.0982	-0.0816	0.0788	-0.0432	-0.0264	0.2575	-0.1945	0.3226	-19.496	-21.982	-32.5245
10	4.3897	-7.0913	-1.3943	17.3202	7.2377	4.6836	0.1157	0.1181	0.1256	-0.0567	-0.3631	0.1237	0.0685	-0.168	0.2474	0.0996	-0.0127	-0.0163	0.1279	-0.0271	0.2095	-18.8176	-14.6555	-33.7062
11	4.5851	-1.5353	1.9139	3.0961	-0.9348	0.8326	-0.1323	0.07	0.0248	0.0129	0.1211	0.0343	-0.056	0.0108	0.0112	0.1254	0.0154	-0.0722	0.1145	-0.058	0.2211	-27.1533	-14.1576	-37.9123
12	2.9152	-0.5292	1.0511	6.0699	-3.6617	2.4078	0.1305	-0.2772	0.633	-0.5328	-0.3008	-0.1793	0.3676	0.0414	0.1703	0.1483	0.0338	-0.1054	0.2358	0.0498	0.4752	-31.9912	-18.9739	-42.3841
13	1.5436	1.0247	4.9292	0.6827	3.3214	17.105	0.212	-0.0394	0.0507	0.1293	-0.0328	0.0256	0.5559	-0.4142	-0.1792	0.152	0.0318	-0.0742	0.1566	-0.0017	0.237	-38.0291	-22.2834	-47.0419
14	8.0648	-5.8227	1.4115	7.559	-4.3129	3.4813	0.1177	0.1312	0.5353	-0.2151	0.0296	-0.131	0.143	-0.1016	-0.1473	0.1043	0.0249	-0.1049	0.1458	-0.0193	0.2048	-30.6773	-18.2838	-50.7452
15	7.5964	2.6449	-0.4696	5.4321	-1.8008	0.6235	-0.0136	0.3805	0.497	-0.1093	0.0871	0.2984	0.0378	-0.0016	-0.0736	0.1264	-0.0064	-0.0595	0.1469	0.0636	0.1747	-24.4235	-16.047	-52.9558
16	12.2574	-0.8259	-5.9062	4.5752	-4.1175	7.359	-0.2826	0.1218	-0.357	0.0548	-0.1775	-0.2499	0.0949	0.1207	0.4601	0.0995	-0.0106	-0.0742	0.1998	-0.0056	0.1808	-16.9589	-18.3944	-50.6435
17	0.8371	0.6159	-2.1773	7.8126	-2.9848	5.9703	-0.0939	-0.1165	-0.1169	-0.1602	-0.2165	0.2099	0.1393	0.3566	0.3104	0.1727	-0.0531	-0.1283	0.1542	-0.0175	0.2039	-19.6147	-23.6942	-44.0604
18	5.7864	4.7019	-6.2441	6.8533	-1.4017	11.1855	0.1348	-0.2038	-0.0433	0.1753	-0.1652	-0.0514	-0.0398	0.2193	0.0304	0.1773	0.0446	-0.0389	0.0865	-0.0167	0.1381	-23.5769	-30.8577	-36.2797
19	5.9354	10.2244	-1.9488	19.3663	-0.6986	4.6724	0.2392	-0.1137	0.3703	0.3192	0.0045	0.567	-0.2289	0.3563	-0.2436	0.0997	-0.0313	0.014	0.1517	-0.1513	0.1781	-37.3536	-33.295	-27.4016
20	10.5215	0.769	-0.2524	0.3757	0.7167	1.731	0.121	-0.2474	0.2197	0.0829	0.0264	-0.0225	0.1344	0.1729	-0.1474	0.1676	-0.0304	-0.0098	0.1633	-0.11	0.1293	-33.3263	-42.4522	-26.2583
21	6.1901	2.142	0.4981	4.8701	0.2061	0.0409	-0.1303	0.0291	-0.3156	-0.1687	0.1611	-0.0995	-0.0201	0.0029	-0.0307	0.1502	-0.0133	0.0274	0.1484	-0.0044	0.1578	37.1508	-13.8067	-10.6629
22	10.7051	3.1277	-2.0376	1.0826	-0.4238	0.5642	-0.1306	0.2333	-0.0942	-0.122	0.0441	0.0315	-0.0573	-0.0841	0.0865	0.1467	-0.0089	-0.0069	0.1666	-0.0056	0.1295	30.9889	-15.1858	-15.4388
23	5.1323	1.1828	-0.9412	2.4782	-3.2061	4.2258	-0.2618	0.1122	-0.189	-0.1588	0.1128	-0.1129	0.1919	-0.1157	0.1489	0.1222	-0.0074	0.0094	0.1426	0.0348	0.2126	20.6874	-18.1048	-14.1834
24	5.7421	3.2158	0.254	4.3312	1.9407	1.294	0.1531	0.1506	0.4717	0.53	-0.3761	0.5374	0.3298	-0.2902	0.2229	0.1548	-0.0356	0.0322	0.2884	0.0308	0.1189	13.7978	-13.2475	-6.4056
25	7.2288	1.8335	1.3877	0.5843	0.5229	0.515	0.0778	-0.2341	0.1998	0.0818	-0.086	0.0296	0.1059	-0.0495	0.0082	0.1253	-0.0128	-0.0101	0.2113	0.0054	0.1492	21.5927	-8.0207	-8.4593
26	1.3918	-0.0914	-1.3722	0.0169	-0.2178	10.1638	-0.0041	0.0829	-0.079	0.0066	-0.0175	0.01	-0.1417	0.1385	0.0215	0.1048	-0.0032	0.0114	0.1633	-0.0034	0.1666	28.0389	-3.9964	-16.3959
27	5.9916	-1.3813	0.8818	4.2711	4.3797	5.4438	0.0678	-0.2953	0.5045	-0.0043	-0.2133	-0.0354	0.0357	-0.3352	0.1454	0.04	-0.014	0.0203	0.2216	-0.0308	0.1903	30.7036	-1.3699	-24.2076
28	5.3248	1.1803	2.4853	3.1011	0.0479	1.2566	0.485	0.3855	-0.0753	0.3683	-0.3919	-0.0337	0.195	0.2438	-0.0931	0.1255	0.0114	0.0154	0.2266	0.0314	0.1648	22.8152	-3.1495	-28.754
29	2.1046	0.0725	1.5719	0.1008	-0.2017	1.8468	-0.0754	0.2126	-0.249	-0.0125	0.0849	-0.0856	-0.0124	-0.0595	-0.0094	0.1296	-0.01	-0.0078	0.2201	-0.0444	0.2212	15.2844	-7.9331	-28.6959
30	3.6119	-2.8445	2.7756	7.7043	-1.4461	2.2358	0.0585	0.2988	0.0973	0.014	-0.1826	0.113	0.0381	0.2476	0.1241	0.0806	-0.0237	0.0119	0.1775	0.0182	0.1782	9.7982	-2.4792	-27.6986
31	6.1846	3.8179	1.7613	2.7347	1.2362	0.5604	0.12	-0.0273	0.0263	-0.0798	-0.0797	-0.1013	-0.0263	-0.0288	-0.0403	0.1396	-0.0029	0.0038	0.1479	0.0178	0.1497	16.1357	3.8158	-24.7243
32	0.2744	-1.1086	-0.218	6.3714	2.5188	1.6008	-0.0918	0.0286	-0.0345	0.0709	0.0082	0.2544	-0.1408	0.0914	0.0836	0.1493	-0.0085	-0.015	0.1351	0.0117	0.1923	23.139	3.083	-19.4506
33	4.0852	-4.5203	3.2382	6.8622	-7.076	9.1253	0.3231	0.0076	0.326	0.068	-0.246	-0.1825	-0.5307	0.4698	-0.0771	0.176	-0.0656	0.0128	0.1693	-0.1148	0.1686	26.4921	5.804	-12.1977
34	4.5502	1.7238	-0.7305	1.0893	1.3813	6.4304	-0.0813	-0.3371	-0.3469	-0.0899	-0.1806	-0.0918	-0.1807	-0.2451	0.2619	0.0976	-0.0099	0.013	0.2006	-0.0374	0.1921	18.8307	1.0707	-9.1611
35	6.5018	1.7244	-0.579	2.7885	-1.9213	1.3935	-0.0491	-0.3134	0.0294	0.1176	-0.0059	-0.0536	-0.0955	-0.0441	0.055	0.1322	0.0078	0.0361	0.1759	-0.0519	0.1858	12.5572	2.0196	-10.2415
36	5.7286	-1.3327	0.5804	0.3382	-0.4052	2.9408	-0.1609	-0.1235	-0.207	0.0315	0.0199	0.0364	-0.0869	-0.0597	0.141	0.1445	-0.0071	0.0173	0.1435	0.0031	0.1536	11.2893	-6.8803	-11.0567
37	4.4771	-3.0377	-2.4873	3.6753	-0.4786	4.2979	-0.0954	-0.0054	-0.0205	0.0064	-0.0713	-0.0654	0.1789	0.1297	0.1667	0.119	-0.0155	0.0553	0.1542	-0.0061	0.1811	18.511	-9.3071	-19.2261
38	10.787	5.4855	-2.885	4.4628	-3.5226	3.3206	0.0475	-0.0326	0.4947	0.0826	0.0233	0.2396	-0.0776	-0.0979	-0.0708	0.069	0.0326	0.0255	0.2209	-0.0557	0.1681	28.5514	-9.6431	-27.7948
39	4.5003	-6.9186	-0.7577	12.4294	4.1448	5.101	0.1352	0.1458	0.085	-0.2435	-0.2023	-0.1109	-0.147	-0.0596	0.0671	0.1313	0.0294	0.0014	0.1937	-0.0079	0.1614	38.3756	-5.5847	-35.2722
40	3.3702	-0.3077	-1.0658	0.8917	1.5773	2.8756	0.2534	0.4858	-0.684	-0.1809	0.0575	-0.2562	-0.3327	-0.0032	-0.3109	0.1672	0.0033	0.0068	0.2437	-0.0929	0.2646	40.4679	-15.855	-34.3287
41	9.8706	-1.2084	6.6079	8.5495	1.1648	4.8879	-0.2718	0.2264	0.0007	-0.0617	0.267	-0.0328	-0.202	0.2159	0.0048	0.1528	-0.0424	-0.0162	0.1091	-0.0714	0.2	-5.2725	-33.1334	-31.6296
42	3.7656	-3.2637	-3.7026	12.1209	9.3492	7.6982	-0.385	-0.0239	0.1067	-0.0292	0.4325	0.004	0.1298	0.2964	-0.0475	0.154	0.0746	-0.0733	0.1565	-0.0636	0.1248	2.1946	-32.8083	-35.1544
43	24.4877	2.9933	-6.0355	1.2258	0.8571	4.6616	-0.282	-0.1947	-0.1367	0.0164	0.1708	0.0265	0.3849	0.4666	0.1112	0.2366	0.0674	-0.0111	0.1433	-0.0685	0.1656	5.9203	-35.5977	-42.8588
44	0.3464	-0.6158	-2.8436	1.1	5.0217	25.0748	0.0279	-0.002	-0.0066	-0.0343	0.0386	-0.0119	-0.9266	-0.1607	-0.0665	0.2984	0.0642	0.0287	0.2763	-0.1633	0.1629	6.6098	-33.8456	-52.5993
45	10.4662	7.6088	-13.2129	19.9451	2.1109	26.2055	-0.7336	-0.0566	-0.3671	-0.1091	0.1157	-0.073	1.2648	0.2076	0.6179	0.1944	0.0368	-0.036	0.1776	-0.1111	0.1101	-3.1162	-33.0978	-52.1502
46	3.9295	1.9664	4.1677	1.0325	1.616	8.9818	0.013	0.2156	-0.1155	0.0201	0.1131	-0.059	-0.1602	0.2672	-0.1261	0.1346	0.0031	-0.042	0.1973	-0.0955	0.1017	-1.9288	-25.4998	-45.178
47	7.2663	3.1932	5.0358	2.2236	1.8519	3.6508	-0.0383	0.0052	0.1937	0.0675	-0.0234	0.2053	-0.044	0.0085	0.0617	0.1353	-0.0205	-0.0364	0.1716	-0.0185	0.1428	2.7321	-18.0405	-34.2219
48	1.311	-2.5848	1.1911	6.7054	-0.7253	2.7617	-0.1219	0.11	-0.0373	-0.0126	-0.0382	0.1964	-0.39	0.3206	0.1602	0.073	-0.0599	-0.0281	0.2604	-0.0053	0.1539	11.9908	-15.7675	-37.681
49	8.5235	-1.4833	-1.1911	0.4135	0.1825	0.1704	-0.0802	-0.0638	-0.2959	0.0843	0.0456	0.0911	-0.0011	0.0056	0.0346	0.1989	-0.0122	0.027	0.2612	-0.0172	0.0408	16.548	-20.1889	-45.4832
50	0.9686	-2.554	-0.0079	9.0419	5.1174	11.2861	0.162	0.1879	-0.0397	-0.3924	-0.3145	0.1969	0.0232	0.4061	0.1525	0.1426	-0.0581	0.067	0.2767	0.0268	0.0984	16.1192	-12.4671	-49.7234
51	13.3813	4.3178	3.0869	1.4367	1.0025	0.7184	0.0814	0.0169	0.223	0.0326	-0.1012	0.053	0.0107	-0.0121	0.0198	0.1613	0.0032	0.0413	0.2593	0.0481	0.1572	8.6631	-10.3344	-46.0412
52	5.2337	0.0766	0.8516	5.1752	-2.397	2.7664	-0.2393	0.4065	0.2378	-0.0906	0.1299	0.0564	-0.0568	0.001	0.1094	0.095	-0.0863	-0.0454	0.2106	0.0114	0.1234	2.0664	-13.3811	-41.9752
53	6.5254	-0.305	-8.3878	8.1061	-1.6909	11.3196	0.1903	-0.0149	0.0233	0.2785	-0.126	-0.05	-0.3824	0.0459	-0.0643	0.1433	-0.0221	-0.0524	0.2161	-0.0189	0.1392	-6.3731	-13.8209	-42.3283
54	5.461	-0.7143	4.7657	4.1447	2.6441	9.6889	-0.1085	0.0719	0.0214	-0.3666	0.405	-0.1729	-0.3675	-0.203	-0.2966	0.1538	-0.0477	-0.0388	0.2256	-0.0255	0.0773	-4.1647	-18.4053	-50.9002
55	1.6756	-0.8479	0.9422	1.1502	1.9137	8.5336	0.2792	0.3725	0.3665	-0.1786	-0.086	-0.3149	0.076	0.4154	-0.1932	0.1353	-0.0318	0.0619	0.3228	0.0195	0.122	2.6366	-20.9709	-56.093
56	10.0715	-2.2427	-0.778	1.0666	1.001	1.2717	-0.097	0.4532	-0.2532	0.0183	0.0826	0.0612	0.0117	0.2508	0.0144	0.1699	-0.0159	0.0055	0.195	-0.0754	0.0619	6.4221	-24.3155	-50.102
57	4.9814	-2.1073	-2.0324	0.8995	0.8649	0.8352	-0.0212	0.3	-0.2183	0.019	-0.0845	0.0813	0.0099	-0.0976	0.1057	0.0754	0.0137	-0.0525	0.2587	-0.0849	0.2102	8.9473	-26.1467	-40.3133
58	4.2297	0.2435	1.8969	0.0192	0.2007	4.3887	-0.0552	0.5046	0.0841	-0.0291	0.0733	0.0131	-0.2645	-0.0394	-0.0181	0.1729	-0.0799	-0.0256	0.1843	0.0064	0.175	11.4783	-21.1999	-31.2935
59	1.195	0.251	1.4175	6.7672	-1.8233	2.4119	0.0262	0.0625	0.0542	0.0811	-0.0966	0.0113	0.0653	0.0292	0.0704	0.1434	-0.011	0.0012	0.1613	0.0089	0.1441	11.2034	-17.4174	-20.4382
60	8.4496	-0.7035	0.4006	9.2831	-0.5395	0.0576	-0.3108	0.2726	-0.171	0.2301	0.3355	-0.2771	0.0125	0.028	-0.0247	0.1655	0.1065	-0.0736	0.177	-0.039	0.2194	13.2176	-27.8546	-18.471
61	1.5634	0.4944	2.509	10.457	-2.1474	4.8671	-0.0853	0.0326	0.1683	-0.4453	-0.1674	0.1106	-0.0051	0.1106	0.2527	0.0568	0.0109	-0.0219	0.1828	-0.0134	0.1777	12.1213	-26.2753	-27.4728
62	1.1103	1.8621	0.1783	5.0677	-3.7049	8.338	0.0203	0.017	0.0146	-0.0853	0.0265	0.0783	0.1728	0.0204	-0.0468	0.1364	0.026	-0.0238	0.128	-0.0122	0.1685	6.107	-31.0243	-22.7974
63	7.6141	-3.5632	-0.4574	2.5974	-2.1846	6.2185	0.0604	-0.146	-0.6697	-0.0447	0.0002	0.3329	-0.0119	0.0942	-0.0607	0.1563	-0.004	-0.0045	0.0683	0.0882	0.2793	3.5975	-33.1847	-12.4428
64	6.8781	-7.493	2.6457	9.3363	-5.5594	7.129	-0.1172	-0.0821	0.115	-0.172	0.1833	-0.0743	0.6725	-0.1931	-0.0661	0.2369	-0.0104	-0.0736	0.1614	-0.0286	0.0375	5.3247	-27.9462	-4.2294
65	1.7837	-0.7556	2.1773	2.0095	-1.7759	3.0903	0.1702	0.0311	-0.1083	0.0974	-0.0415	0.077	0.1135	0.0603	-0.1287	0.1378	0.0025	-0.0346	0.1667	0.0192	0.1719	5.0647	-21.6737	-14.0375
66	6.9269	-0.7071	3.1011	4.6231	-0.2861	1.3965	-0.051	0.0019	-0.3157	-0.1856	0.1655	-0.1195	-0.0478	-0.0142	-0.1144	0.1167	-0.0083	-0.0411	0.1706	0.0035	0.1402	-3.9658	-19.931	-26.4745
67	6.7806	-1.1909	-0.3115	3.5972	-2.5864	2.0735	0.0083	0.119	0.2865	-0.0939	-0.191	-0.2856	0.0757	0.127	0.1826	0.1104	-0.0817	0.0041	0.1111	0.0018	0.2545	-11.8191	-22.8496	-23.8955
68	9.3858	-1.7055	-1.6619	0.3108	0.3021	0.2944	-0.0705	-0.1631	-0.1571	0.0036	0.0371	0.0319	0.0109	0.0289	0.0335	0.1431	-0.0199	-0.0161	0.1302	0.0135	0.1815	-15.056	-27.3094	-16.9839
69	8.1989	-4.3311	-1.4368	4.912	1.7919	0.6601	0.1277	-0.1063	-0.0786	0.0527	-0.1331	-0.0139	0.0341	-0.0584	0.0054	0.1422	-0.0285	0.0369	0.1332	0.0591	0.1647	-15.6046	-26.9307	-11.6305
70	4.2916	-1.0228	-3.92	1.3004	1.7195	4.1642	-0.4101	0.0804	-0.1872	-0.2065	0.1052	0.2295	0.1456	0.025	0.3049	0.1383	-0.0378	0.0124	0.1444	0.0456	0.2165	-13.9268	-17.3273	-14.7301
71	2.9049	-4.1852	3.5163	6.5616	-3.6796	7.9099	-0.2061	-0.1997	-0.0584	0.1965	0.3098	0.0528	-0.5274	-0.2638	-0.1038	0.0847	-0.0035	-0.0084	0.1758	-0.0003	0.1891	-6.5941	-14.7172	-20.3427
72	5.9608	6.7389	-4.5027	9.5811	-1.5057	9.9666	-0.1459	-0.1675	-0.0553	-0.4261	-0.0423	0.0404	-0.354	0.3595	0.1882	0.1191	-0.0246	-0.0457	0.1392	0.0232	0.1885	-0.0886	-9.9065	-19.5613
73	1.1527	0.4643	2.0439	0.1873	0.8232	3.6255	0.1343	-0.1736	-0.047	0.046	-0.0627	-0.0136	0.2314	-0.2951	-0.0716	0.151	-0.0283	-0.0195	0.22	0.0049	0.2118	0.6391	-14.079	-11.0378
74	5.1748	0.3607	-1.8766	2.5013	-0.0877	0.6822	0.0564	-0.2169	-0.1033	-0.1871	-0.0817	-0.2021	-0.0266	0.0727	0.0252	0.1324	-0.0303	0.004	0.1786	0.0161	0.1386	-3.014	-14.3774	-5.9268
75	4.0697	1.1914	1.5293	0.3665	0.5862	1.6683	0.2317	-0.0865	-0.1044	0.0933	-0.0265	-0.0518	0.2782	-0.0015	-0.2053	0.1492	-0.0102	-0.0021	0.1694	0.0168	0.1557	-2.027	-23.7033	-5.0953
76	9.4875	5.8603	-3.0151	3.62	-1.8627	0.9599	0.0832	-0.252	-0.2373	0.043	-0.1453	-0.1439	-0.0197	0.0745	0.0621	0.1465	-0.0047	-0.0449	0.145	0.0342	0.2647	-3.9444	-25.5252	-13.7715
77	0.8963	-1.1606	-1.3732	1.5066	1.781	2.1113	-0.0214	-0.0104	-0.0413	0.0147	-0.0017	0.0427	0.0306	0.0157	0.023	0.1707	0.0068	-0.0518	0.1155	-0.0072	0.2339	-4.1329	-30.818	-19.8979
78	4.1957	-1.0244	1.5596	2.9596	-2.7381	2.6312	0.1467	-0.4441	0.0413	-0.139	0.1442	0.3383	0.1403	-0.1885	-0.2909	0.1195	0.0028	-0.0825	0.1375	-0.0894	0.2494	-9.2209	-26.6471	-30.6492
79	8.3719	-2.9319	1.439	3.8467	2.4444	3.3322	-0.1051	0.1113	-0.0472	-0.0508	-0.0484	0.1816	-0.1024	0.0322	0.1535	0.143	0.0013	-0.0262	0.1519	-0.0337	0.1513	-9.8911	-27.2268	-40.1801
80	2.8124	0.4419	-3.104	9.6777	-5.536	6.0789	-0.02	-0.3303	-0.4661	-0.5458	-0.1566	0.5659	0.3187	0.429	0.1765	0.1256	0.0012	-0.0445	0.1695	-0.0809	0.2514	-5.0118	-36.3216	-40.4805
81	5.2126	4.4932	4.7346	4.3501	4.5454	5.6507	-0.0248	-0.053	-0.1504	-0.019	0.1409	-0.0276	-0.1199	-0.0287	-0.116	0.1342	0.0205	-0.0088	0.1626	0.0068	0.1421	15.8378	9.3198	-13.3674
82	4.2211	1.4526	4.9531	2.1772	-0.9101	9.8901	-0.0344	-0.3329	0.5382	-0.0759	-0.155	0.4724	0.0816	-0.3308	0.1894	0.0995	-0.0194	0.0117	0.158	-0.032	0.2367	6.3231	-1.8889	-22.2568
83	3.7984	0.1124	-7.1405	0.0392	-0.1966	13.4715	0.2197	0.7226	0.2442	0.0729	0.1239	0.0194	-0.2851	-1.3383	-0.3436	0.3614	0.1443	0.1224	0.4087	0.0982	0.4872	-30.1396	-11.3224	-49.3984
84	5.3839	-1.2948	5.1966	1.2406	0.9444	10.2015	-0.2832	0.2472	0.3052	-0.042	0.0262	-0.0836	-0.5132	0.4366	0.257	0.1246	-0.0137	-0.0743	0.0924	0.0157	0.256	-16.6564	-11.9328	-39.7432
85	3.1554	-1.7323	-2.0461	0.9943	1.3177	2.1995	0.0058	-0.239	0.175	-0.0394	0.0488	-0.0848	-0.1655	-0.2131	-0.0546	0.1374	0.0168	-0.0229	0.199	-0.0146	0.2155	-7.1666	-7.9795	-10.355
86	9.586	2.3818	-1.1437	5.6356	-3.3128	1.9552	0.3459	0.0699	-0.0506	0.2411	-0.1205	0.3691	-0.1358	0.0735	-0.2255	0.1428	-0.0526	0.0343	0.11	0.033	0.1687	-14.4365	-22.6644	-4.9135
87	3.8035	-3.384	-5.8723	9.7573	4.702	9.1181	-0.0579	0.4246	-0.0086	0.0235	0.0976	0.5516	0.0696	-0.6401	-0.0397	0.1753	-0.0941	-0.029	0.3252	-0.0163	0.0702	-1.7697	-8.9527	-51.916
88	7.5844	-4.3895	0.9249	2.66	-0.5349	0.1962	0.4305	0.1976	0.5829	-0.3748	-0.3056	-0.3518	0.0197	0.021	-0.1248	0.3431	0.0589	0.1581	0.4146	0.0159	0.4913	13.4417	-16.2817	-55.5317

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	140 - 148
2	X-RAY DIFFRACTION	2	A	149 - 153
3	X-RAY DIFFRACTION	3	A	154 - 158
4	X-RAY DIFFRACTION	4	A	159 - 163
5	X-RAY DIFFRACTION	5	A	164 - 169
6	X-RAY DIFFRACTION	6	A	170 - 179
7	X-RAY DIFFRACTION	7	A	180 - 186
8	X-RAY DIFFRACTION	8	A	187 - 192
9	X-RAY DIFFRACTION	9	A	193 - 196
10	X-RAY DIFFRACTION	10	A	197 - 202
11	X-RAY DIFFRACTION	11	A	203 - 210
12	X-RAY DIFFRACTION	12	A	211 - 214
13	X-RAY DIFFRACTION	13	A	215 - 220
14	X-RAY DIFFRACTION	14	A	221 - 226
15	X-RAY DIFFRACTION	15	A	227 - 230
16	X-RAY DIFFRACTION	16	A	231 - 235
17	X-RAY DIFFRACTION	17	A	236 - 242
18	X-RAY DIFFRACTION	18	A	243 - 250
19	X-RAY DIFFRACTION	19	A	251 - 257
20	X-RAY DIFFRACTION	20	A	258 - 266
21	X-RAY DIFFRACTION	21	B	139 - 145
22	X-RAY DIFFRACTION	22	B	146 - 151
23	X-RAY DIFFRACTION	23	B	152 - 159
24	X-RAY DIFFRACTION	24	B	160 - 165
25	X-RAY DIFFRACTION	25	B	166 - 173
26	X-RAY DIFFRACTION	26	B	174 - 179
27	X-RAY DIFFRACTION	27	B	180 - 184
28	X-RAY DIFFRACTION	28	B	185 - 192
29	X-RAY DIFFRACTION	29	B	193 - 196
30	X-RAY DIFFRACTION	30	B	197 - 203
31	X-RAY DIFFRACTION	31	B	204 - 209
32	X-RAY DIFFRACTION	32	B	210 - 216
33	X-RAY DIFFRACTION	33	B	217 - 222
34	X-RAY DIFFRACTION	34	B	223 - 227
35	X-RAY DIFFRACTION	35	B	228 - 231
36	X-RAY DIFFRACTION	36	B	232 - 236
37	X-RAY DIFFRACTION	37	B	237 - 246
38	X-RAY DIFFRACTION	38	B	247 - 253
39	X-RAY DIFFRACTION	39	B	254 - 261
40	X-RAY DIFFRACTION	40	B	262 - 267
41	X-RAY DIFFRACTION	41	C	139 - 145
42	X-RAY DIFFRACTION	42	C	146 - 152
43	X-RAY DIFFRACTION	43	C	153 - 156
44	X-RAY DIFFRACTION	44	C	157 - 161
45	X-RAY DIFFRACTION	45	C	162 - 166
46	X-RAY DIFFRACTION	46	C	167 - 176
47	X-RAY DIFFRACTION	47	C	177 - 184
48	X-RAY DIFFRACTION	48	C	185 - 192
49	X-RAY DIFFRACTION	49	C	193 - 198
50	X-RAY DIFFRACTION	50	C	199 - 204
51	X-RAY DIFFRACTION	51	C	205 - 209
52	X-RAY DIFFRACTION	52	C	210 - 216
53	X-RAY DIFFRACTION	53	C	217 - 222
54	X-RAY DIFFRACTION	54	C	223 - 228
55	X-RAY DIFFRACTION	55	C	229 - 234
56	X-RAY DIFFRACTION	56	C	235 - 241
57	X-RAY DIFFRACTION	57	C	242 - 247
58	X-RAY DIFFRACTION	58	C	248 - 253
59	X-RAY DIFFRACTION	59	C	254 - 261
60	X-RAY DIFFRACTION	60	C	262 - 267
61	X-RAY DIFFRACTION	61	D	139 - 145
62	X-RAY DIFFRACTION	62	D	146 - 153
63	X-RAY DIFFRACTION	63	D	154 - 159
64	X-RAY DIFFRACTION	64	D	160 - 164
65	X-RAY DIFFRACTION	65	D	165 - 176
66	X-RAY DIFFRACTION	66	D	177 - 184
67	X-RAY DIFFRACTION	67	D	185 - 190
68	X-RAY DIFFRACTION	68	D	191 - 195
69	X-RAY DIFFRACTION	69	D	196 - 202
70	X-RAY DIFFRACTION	70	D	203 - 210
71	X-RAY DIFFRACTION	71	D	211 - 216
72	X-RAY DIFFRACTION	72	D	217 - 222
73	X-RAY DIFFRACTION	73	D	223 - 227
74	X-RAY DIFFRACTION	74	D	228 - 231
75	X-RAY DIFFRACTION	75	D	232 - 237
76	X-RAY DIFFRACTION	76	D	238 - 242
77	X-RAY DIFFRACTION	77	D	243 - 248
78	X-RAY DIFFRACTION	78	D	249 - 254
79	X-RAY DIFFRACTION	79	D	255 - 261
80	X-RAY DIFFRACTION	80	D	262 - 267
81	X-RAY DIFFRACTION	81	E	602 - 607
82	X-RAY DIFFRACTION	82	E	608 - 612
83	X-RAY DIFFRACTION	83	F	602 - 607
84	X-RAY DIFFRACTION	84	F	608 - 612
85	X-RAY DIFFRACTION	85	G	602 - 607
86	X-RAY DIFFRACTION	86	G	608 - 612
87	X-RAY DIFFRACTION	87	H	602 - 607
88	X-RAY DIFFRACTION	88	H	608 - 612