- PDB-5v4b: Crystal structure of the Skp1-FBXW7-DISC1 complex -
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基本情報
登録情報
データベース: PDB / ID: 5v4b
タイトル
Crystal structure of the Skp1-FBXW7-DISC1 complex
要素
DISC1 peptide
F-box/WD repeat-containing protein 7
S-phase kinase-associated protein 1,S-phase kinase-associated protein 1
キーワード
TRANSCRIPTION / Ubiquitin ligase/psychiatric disorders / TRANSCRIPTION-CELL C complex
機能・相同性
機能・相同性情報
pyramidal neuron migration to cerebral cortex / negative regulation of SREBP signaling pathway / negative regulation of triglyceride biosynthetic process / regulation of cell migration involved in sprouting angiogenesis / negative regulation of hepatocyte proliferation / regulation of lipid storage / positive regulation of epidermal growth factor-activated receptor activity / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain ...pyramidal neuron migration to cerebral cortex / negative regulation of SREBP signaling pathway / negative regulation of triglyceride biosynthetic process / regulation of cell migration involved in sprouting angiogenesis / negative regulation of hepatocyte proliferation / regulation of lipid storage / positive regulation of epidermal growth factor-activated receptor activity / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain / Parkin-FBXW7-Cul1 ubiquitin ligase complex / F-box domain binding / ubiquitin recycling / ubiquitin-protein transferase activator activity / regulation of dendritic spine development / regulation of mitophagy / regulation of synapse maturation / PcG protein complex / phosphothreonine residue binding / regulation of cell cycle G1/S phase transition / negative regulation of osteoclast development / positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / dynein complex / positive regulation of proteasomal protein catabolic process / Cul7-RING ubiquitin ligase complex / positive regulation of ubiquitin protein ligase activity / positive regulation of ubiquitin-dependent protein catabolic process / Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling / non-motile cilium assembly / maintenance of protein location in nucleus / vasculature development / sister chromatid cohesion / protein localization to centrosome / positive regulation of ubiquitin-protein transferase activity / positive regulation of protein targeting to mitochondrion / intermediate filament cytoskeleton / positive regulation of cell-matrix adhesion / SCF ubiquitin ligase complex / regulation of postsynapse organization / ciliary base / ubiquitin ligase complex scaffold activity / kinesin complex / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / positive regulation of neuroblast proliferation / negative regulation of Notch signaling pathway / Prolactin receptor signaling / lipid homeostasis / protein monoubiquitination / Association of TriC/CCT with target proteins during biosynthesis / kinesin binding / detection of temperature stimulus involved in sensory perception of pain / cullin family protein binding / ubiquitin-like ligase-substrate adaptor activity / positive regulation of Wnt signaling pathway / cilium assembly / TOR signaling / GABA-ergic synapse / canonical Wnt signaling pathway / vasculogenesis / positive regulation of axon extension / protein K48-linked ubiquitination / Nuclear events stimulated by ALK signaling in cancer / response to electrical stimulus / Notch signaling pathway / regulation of synaptic transmission, glutamatergic / Regulation of BACH1 activity / MAP3K8 (TPL2)-dependent MAPK1/3 activation / cyclin binding / ciliary basal body / negative regulation of protein binding / ubiquitin binding / positive regulation of protein ubiquitination / SCF-beta-TrCP mediated degradation of Emi1 / NIK-->noncanonical NF-kB signaling / molecular function activator activity / Vpu mediated degradation of CD4 / Dectin-1 mediated noncanonical NF-kB signaling / Degradation of GLI1 by the proteasome / Activation of NF-kappaB in B cells / Negative regulation of NOTCH4 signaling / Iron uptake and transport / GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 / Degradation of GLI2 by the proteasome / GLI3 is processed to GLI3R by the proteasome / lung development / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / neuron migration / protein destabilization / Degradation of beta-catenin by the destruction complex / regulation of circadian rhythm / NOTCH1 Intracellular Domain Regulates Transcription / CLEC7A (Dectin-1) signaling / beta-catenin binding / SCF(Skp2)-mediated degradation of p27/p21 / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / positive regulation of neuron projection development / FCERI mediated NF-kB activation / microtubule cytoskeleton organization / neuron cellular homeostasis 類似検索 - 分子機能
S-phasekinase-associatedprotein1,S-phasekinase-associatedprotein1 / Cyclin-A/CDK2-associated protein p19 / p19A / Organ of Corti protein 2 / OCP-2 / Organ of Corti ...Cyclin-A/CDK2-associated protein p19 / p19A / Organ of Corti protein 2 / OCP-2 / Organ of Corti protein II / OCP-II / RNA polymerase II elongation factor-like protein / SIII / Transcription elongation factor B polypeptide 1-like / p19skp1
解像度: 2.6→42.93 Å / Cor.coef. Fo:Fc: 0.949 / Cor.coef. Fo:Fc free: 0.929 / SU B: 13.104 / SU ML: 0.14 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.22 / ESU R Free: 0.194 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS