Entry Database : PDB / ID : 5unj Structure visualization Downloads & linksTitle Structure of Human Liver Receptor Homolog 1 in complex with PGC1a and RJW100 ComponentsNuclear receptor subfamily 5 group A member 2 Peroxisome proliferator-activated gamma coactivator 1-alpha DetailsKeywords NUCLEAR PROTEIN / Nuclear receptor / agonist / coregulatorFunction / homology Function and homology informationFunction Domain/homology Component
Regulation of gene expression in early pancreatic precursor cells / pancreas morphogenesis / calcineurin-mediated signaling / acinar cell differentiation / tissue development / positive regulation of fatty acid oxidation / : / bile acid metabolic process / lncRNA binding / response to muscle activity ... Regulation of gene expression in early pancreatic precursor cells / pancreas morphogenesis / calcineurin-mediated signaling / acinar cell differentiation / tissue development / positive regulation of fatty acid oxidation / : / bile acid metabolic process / lncRNA binding / response to muscle activity / embryo development ending in birth or egg hatching / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration / temperature homeostasis / homeostatic process / intracellular glucose homeostasis / response to starvation / fatty acid oxidation / response to dietary excess / positive regulation of viral genome replication / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / energy homeostasis / brown fat cell differentiation / positive regulation of gluconeogenesis / digestion / hormone-mediated signaling pathway / respiratory electron transport chain / mitochondrion organization / RNA splicing / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / cellular response to leukemia inhibitory factor / transcription coregulator binding / gluconeogenesis / cholesterol homeostasis / nuclear receptor binding / transcription initiation at RNA polymerase II promoter / transcription coregulator activity / negative regulation of smooth muscle cell proliferation / circadian regulation of gene expression / Heme signaling / SUMOylation of intracellular receptors / Transcriptional activation of mitochondrial biogenesis / regulation of circadian rhythm / PPARA activates gene expression / chromatin DNA binding / mRNA processing / phospholipid binding / PML body / positive regulation of DNA-binding transcription factor activity / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / Regulation of RUNX2 expression and activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / Circadian Clock / positive regulation of cold-induced thermogenesis / regulation of cell population proliferation / cellular response to oxidative stress / protein-containing complex assembly / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / neuron apoptotic process / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / negative regulation of neuron apoptotic process / sequence-specific DNA binding / transcription coactivator activity / protein stabilization / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / ubiquitin protein ligase binding / chromatin binding / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function PGC-1alpha, RNA recognition motif / PGC-1 / Nuclear hormone receptor family 5 / Retinoid X Receptor / Retinoid X Receptor / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily ... PGC-1alpha, RNA recognition motif / PGC-1 / Nuclear hormone receptor family 5 / Retinoid X Receptor / Retinoid X Receptor / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology Chem-RJW / Nuclear receptor subfamily 5 group A member 2 / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.959 Å DetailsAuthors Mays, S.G. / Ortlund, E.A. Funding support United States, 4items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) R01DK095750 United States National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) F31DK111171 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) T32GM008602 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) NIH K12GM000680 United States
CitationJournal : Mol. Pharmacol. / Year : 2017Title : Structure and Dynamics of the Liver Receptor Homolog 1-PGC1 alpha Complex.Authors : Mays, S.G. / Okafor, C.D. / Tuntland, M.L. / Whitby, R.J. / Dharmarajan, V. / Stec, J. / Griffin, P.R. / Ortlund, E.A. History Deposition Jan 31, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 19, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jun 7, 2017 Group : Database referencesRevision 1.2 Sep 20, 2017 Group : Author supporting evidence / Refinement description / Category : pdbx_audit_support / software / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Dec 25, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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