登録情報 | データベース: PDB / ID: 5udy |
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タイトル | Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7) |
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要素 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 |
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キーワード | HYDROLASE / sphingomyelinase / sphingomyelin |
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機能・相同性 | 機能・相同性情報
regulation of intestinal lipid absorption / positive regulation of intestinal cholesterol absorption / Glycosphingolipid metabolism / positive regulation of sphingomyelin catabolic process / lipid digestion / sphingomyelin metabolic process / sphingomyelin phosphodiesterase / sphingomyelin phosphodiesterase activity / positive regulation of ceramide biosynthetic process / glycosphingolipid metabolic process ...regulation of intestinal lipid absorption / positive regulation of intestinal cholesterol absorption / Glycosphingolipid metabolism / positive regulation of sphingomyelin catabolic process / lipid digestion / sphingomyelin metabolic process / sphingomyelin phosphodiesterase / sphingomyelin phosphodiesterase activity / positive regulation of ceramide biosynthetic process / glycosphingolipid metabolic process / phosphoric diester hydrolase activity / negative regulation of DNA replication / microvillus / fatty acid homeostasis / negative regulation of cell population proliferation / Golgi apparatus / zinc ion binding / membrane / plasma membrane類似検索 - 分子機能 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase / Type I phosphodiesterase / nucleotide pyrophosphatase / Alkaline Phosphatase, subunit A / Alkaline Phosphatase, subunit A / Alkaline-phosphatase-like, core domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 IODIDE ION / Ectonucleotide pyrophosphatase/phosphodiesterase family member 7類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.6 Å |
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データ登録者 | Gorelik, A. / Liu, F. / Illes, K. / Nagar, B. |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Canadian Institutes of Health Research (CIHR) | MOP-133535 | カナダ |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. 著者: Gorelik, A. / Liu, F. / Illes, K. / Nagar, B. |
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履歴 | 登録 | 2016年12月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年3月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年5月10日 | Group: Database references |
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改定 1.2 | 2017年9月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2020年1月8日 | Group: Author supporting evidence / Data collection / カテゴリ: chem_comp / pdbx_audit_support Item: _chem_comp.type / _pdbx_audit_support.funding_organization |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_validate_close_contact / struct_asym / struct_conn / struct_conn_type / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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