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Structure paper

TitleCrystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 7087-7094, Year 2017
Publish dateSep 14, 2016 (structure data deposition date)
AuthorsGorelik, A. / Liu, F. / Illes, K. / Nagar, B.
External linksJ. Biol. Chem. / PubMed:28292932
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-5tcd:
Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5udy:
Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-IOD:
IODIDE ION

ChemComp-PC:
PHOSPHOCHOLINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / sphingomyelinase / sphingomyelin / phosphocholine / glycosylphosphatidylinositol

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