登録情報 | データベース: PDB / ID: 5u6i |
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タイトル | Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity |
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要素 | Mitogen-activated protein kinase 1 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / MLi-2 / LRRK2 / kinase inhibitor / kinase selectivity / Parkinson's disease / TRANSFERASE / SERINE/ THREONINE-PROTEIN KINASE / MAP KINASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
phospho-PLA2 pathway / RAF-independent MAPK1/3 activation / MAPK1 (ERK2) activation / Signaling by NODAL / Frs2-mediated activation / ERK/MAPK targets / ERKs are inactivated / Activation of the AP-1 family of transcription factors / RHO GTPases Activate WASPs and WAVEs / IFNG signaling activates MAPKs ...phospho-PLA2 pathway / RAF-independent MAPK1/3 activation / MAPK1 (ERK2) activation / Signaling by NODAL / Frs2-mediated activation / ERK/MAPK targets / ERKs are inactivated / Activation of the AP-1 family of transcription factors / RHO GTPases Activate WASPs and WAVEs / IFNG signaling activates MAPKs / Negative feedback regulation of MAPK pathway / Gastrin-CREB signalling pathway via PKC and MAPK / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / Golgi Cisternae Pericentriolar Stack Reorganization / Regulation of actin dynamics for phagocytic cup formation / Estrogen-stimulated signaling through PRKCZ / Growth hormone receptor signaling / Spry regulation of FGF signaling / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Oxidative Stress Induced Senescence / Senescence-Associated Secretory Phenotype (SASP) / Oncogene Induced Senescence / Signaling by Activin / Downregulation of SMAD2/3:SMAD4 transcriptional activity / Signal attenuation / NCAM signaling for neurite out-growth / Negative regulation of FGFR1 signaling / Negative regulation of FGFR3 signaling / Negative regulation of FGFR4 signaling / Regulation of the apoptosome activity / Signal transduction by L1 / Negative regulation of FGFR2 signaling / RHO GTPases Activate NADPH Oxidases / Negative regulation of MAPK pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interferon gamma signaling / FCERI mediated MAPK activation / Regulation of HSF1-mediated heat shock response / MAP2K and MAPK activation / Recycling pathway of L1 / neural crest cell development / diadenosine tetraphosphate biosynthetic process / cardiac neural crest cell development involved in heart development / caveolin-mediated endocytosis / cytosine metabolic process / response to epidermal growth factor / mitogen-activated protein kinase kinase kinase binding / positive regulation of macrophage proliferation / outer ear morphogenesis / Thrombin signalling through proteinase activated receptors (PARs) / regulation of cellular pH / RAF/MAP kinase cascade / regulation of Golgi inheritance / ERBB signaling pathway / labyrinthine layer blood vessel development / mammary gland epithelial cell proliferation / trachea formation / Neutrophil degranulation / regulation of early endosome to late endosome transport / regulation of stress-activated MAPK cascade / : / positive regulation of macrophage chemotaxis / lung morphogenesis / ERBB2-ERBB3 signaling pathway / response to exogenous dsRNA / regulation of cytoskeleton organization / face development / progesterone receptor signaling pathway / androgen receptor signaling pathway / pseudopodium / Bergmann glial cell differentiation / negative regulation of cell differentiation / positive regulation of telomere capping / thyroid gland development / decidualization / steroid hormone receptor signaling pathway / MAP kinase activity / regulation of ossification / phosphatase binding / mitogen-activated protein kinase / Schwann cell development / stress-activated MAPK cascade / positive regulation of cardiac muscle cell proliferation / lipopolysaccharide-mediated signaling pathway / sensory perception of pain / positive regulation of telomere maintenance via telomerase / cellular response to cadmium ion / ERK1 and ERK2 cascade / myelination / cellular response to amino acid starvation / dendrite cytoplasm / phosphotyrosine residue binding / RNA polymerase II CTD heptapeptide repeat kinase activity / insulin-like growth factor receptor signaling pathway / thymus development / positive regulation of peptidyl-threonine phosphorylation / caveola / positive regulation of translation / long-term synaptic potentiation / animal organ morphogenesis類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase, ERK1/2 / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain ...Mitogen-activated protein (MAP) kinase, ERK1/2 / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-81Y / Mitogen-activated protein kinase 1類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.69 Å |
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データ登録者 | Scott, J.D. / DeMong, D.E. / Fell, M.J. / Mirescu, C. / Basu, K. / Greshock, T.J. / Morrow, J.A. / Xiao, L. / Hruza, A. / Harris, J. ...Scott, J.D. / DeMong, D.E. / Fell, M.J. / Mirescu, C. / Basu, K. / Greshock, T.J. / Morrow, J.A. / Xiao, L. / Hruza, A. / Harris, J. / Tiscia, H.E. / Chang, R.K. / Embrey, M.W. / McCauley, J.A. / Li, W. / Lin, S. / Liu, H. / Dai, X. / Baptista, M. / Agnihotri, G. / Columbus, J. / Mei, H. / Poirier, M. / Zhou, X. / Lin, Y. / Yin, Z. / Sanders, J.M. / Drolet, R.E. / Kern, J.T. / Kennedy, M.E. / Parker, E.M. / Stamford, A.W. / Nargund, R. / Miller, M.W. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2017 タイトル: Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. 著者: Scott, J.D. / DeMong, D.E. / Greshock, T.J. / Basu, K. / Dai, X. / Harris, J. / Hruza, A. / Li, S.W. / Lin, S.I. / Liu, H. / Macala, M.K. / Hu, Z. / Mei, H. / Zhang, H. / Walsh, P. / Poirier, ...著者: Scott, J.D. / DeMong, D.E. / Greshock, T.J. / Basu, K. / Dai, X. / Harris, J. / Hruza, A. / Li, S.W. / Lin, S.I. / Liu, H. / Macala, M.K. / Hu, Z. / Mei, H. / Zhang, H. / Walsh, P. / Poirier, M. / Shi, Z.C. / Xiao, L. / Agnihotri, G. / Baptista, M.A. / Columbus, J. / Fell, M.J. / Hyde, L.A. / Kuvelkar, R. / Lin, Y. / Mirescu, C. / Morrow, J.A. / Yin, Z. / Zhang, X. / Zhou, X. / Chang, R.K. / Embrey, M.W. / Sanders, J.M. / Tiscia, H.E. / Drolet, R.E. / Kern, J.T. / Sur, S.M. / Renger, J.J. / Bilodeau, M.T. / Kennedy, M.E. / Parker, E.M. / Stamford, A.W. / Nargund, R. / McCauley, J.A. / Miller, M.W. |
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履歴 | 登録 | 2016年12月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年3月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年4月26日 | Group: Data collection / Database references |
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改定 1.2 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / software Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name |
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