登録情報 | データベース: PDB / ID: 5t4s |
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タイトル | Novel Approach of Fragment-Based Lead Discovery applied to Renin Inhibitors |
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要素 | Renin |
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キーワード | HYDROLASE/HYDROLASE inhibitor / protein-ligand complex / HYDROLASE-HYDROLASE inhibitor complex |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / hormone-mediated signaling pathway / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 6-chloro-N-[(furan-2-yl)methyl]pyrazin-2-amine / Chem-PG6 / TRIETHYLENE GLYCOL / Renin類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.64 Å |
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データ登録者 | Snell, G.P. / Behnke, C.A. / Okada, K. / Oki, H. / Sang, B.C. / Lane, W. |
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引用 | ジャーナル: Bioorg.Med.Chem. / 年: 2016 タイトル: Novel approach of fragment-based lead discovery applied to renin inhibitors. 著者: Tawada, M. / Suzuki, S. / Imaeda, Y. / Oki, H. / Snell, G. / Behnke, C.A. / Kondo, M. / Tarui, N. / Tanaka, T. / Kuroita, T. / Tomimoto, M. |
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履歴 | 登録 | 2016年8月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年10月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年11月2日 | Group: Database references |
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改定 1.2 | 2020年7月29日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / citation ...chem_comp / citation / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_oper_list / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _citation.journal_id_CSD / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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