- PDB-5s8c: XChem group deposition -- Crystal Structure of the second bromodo... -
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基本情報
登録情報
データベース: PDB / ID: 5s8c
タイトル
XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)
要素
PH-interacting protein
キーワード
SIGNALING PROTEIN / SGC - Diamond I04-1 fragment screening / bromodomain / PHIP / XChemExplorer
機能・相同性
機能・相同性情報
regulation of cell morphogenesis / positive regulation of insulin-like growth factor receptor signaling pathway / RHOBTB2 GTPase cycle / cytoskeleton organization / positive regulation of mitotic nuclear division / negative regulation of extrinsic apoptotic signaling pathway / regulation of protein phosphorylation / insulin receptor binding / lysine-acetylated histone binding / insulin receptor signaling pathway ...regulation of cell morphogenesis / positive regulation of insulin-like growth factor receptor signaling pathway / RHOBTB2 GTPase cycle / cytoskeleton organization / positive regulation of mitotic nuclear division / negative regulation of extrinsic apoptotic signaling pathway / regulation of protein phosphorylation / insulin receptor binding / lysine-acetylated histone binding / insulin receptor signaling pathway / regulation of cell shape / positive regulation of cell population proliferation / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleus 類似検索 - 分子機能
解像度: 1.25→36.2 Å / Cor.coef. Fo:Fc: 0.977 / Cor.coef. Fo:Fc free: 0.965 / SU B: 2.055 / SU ML: 0.038 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.044 / ESU R Free: 0.045 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
反射数
%反射
Selection details
Rfree
0.1769
1610
4.9 %
RANDOM
Rwork
0.1375
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obs
0.1394
31348
93.19 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK