histone H3K9me/H3K9me2 demethylase activity / [histone H3]-dimethyl-L-lysine9 demethylase / histone H3K9 demethylase activity / antioxidant activity / histone deacetylase complex / transcription coregulator activity / HDMs demethylate histones / chromatin DNA binding / regulation of transcription by RNA polymerase II / chromatin ...histone H3K9me/H3K9me2 demethylase activity / [histone H3]-dimethyl-L-lysine9 demethylase / histone H3K9 demethylase activity / antioxidant activity / histone deacetylase complex / transcription coregulator activity / HDMs demethylate histones / chromatin DNA binding / regulation of transcription by RNA polymerase II / chromatin / nucleoplasm / metal ion binding 類似検索 - 分子機能
Histone demethylase JHDM2-like / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Jelly Rolls / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性
PanDDA analysis group deposition of Human JMJD1B screened against the DSPL Fragment Library
タイプ
changed state
解説
Jmjc Domain of Human JMJD1B screened against the DSPL Fragment Library by X-ray Crystallography at the XChem facility of Diamond Light Source beamline I04-1
解像度: 1.47→47.42 Å / Cor.coef. Fo:Fc: 0.97 / Cor.coef. Fo:Fc free: 0.963 / SU B: 1.592 / SU ML: 0.057 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.068 / ESU R Free: 0.069 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
反射数
%反射
Selection details
Rfree
0.2056
7849
5 %
RANDOM
Rwork
0.1829
-
-
-
obs
0.184
150105
97.84 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK