- PDB-5om0: CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide ar... -
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Basic information
Entry
Database: PDB / ID: 5om0
Title
CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640
Components
14-3-3 protein sigma,Zinc finger protein GLI1
Keywords
SIGNALING PROTEIN / 14-3-3 proteins / Protein chimera / phosphopeptide-binding
Function / homology
Function and homology information
notochord regression / GLI proteins bind promoters of Hh responsive genes to promote transcription / regulation of hepatocyte proliferation / GLI-SUFU complex / ventral midline development / epidermal cell differentiation / pituitary gland development / proximal/distal pattern formation / ciliary tip / prostate gland development ...notochord regression / GLI proteins bind promoters of Hh responsive genes to promote transcription / regulation of hepatocyte proliferation / GLI-SUFU complex / ventral midline development / epidermal cell differentiation / pituitary gland development / proximal/distal pattern formation / ciliary tip / prostate gland development / positive regulation of cell cycle G1/S phase transition / cerebellar cortex morphogenesis / regulation of smoothened signaling pathway / positive regulation of smoothened signaling pathway / dorsal/ventral pattern formation / regulation of osteoblast differentiation / ciliary base / smoothened signaling pathway / digestive tract morphogenesis / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / axoneme / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / spermatid development / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / Hedgehog 'off' state / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / positive regulation of cardiac muscle cell proliferation / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / positive regulation of DNA replication / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / liver regeneration / TP53 Regulates Metabolic Genes / Degradation of GLI1 by the proteasome / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Hedgehog 'on' state / negative regulation of protein kinase activity / lung development / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of canonical Wnt signaling pathway / response to wounding / osteoblast differentiation / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of cell growth / microtubule binding / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of cell cycle / positive regulation of cell migration / cadherin binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / extracellular space / extracellular exosome / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function
C2H2-type zinc-finger protein GLI-like / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / Zinc finger, C2H2 type / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues ...C2H2-type zinc-finger protein GLI-like / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / Zinc finger, C2H2 type / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
14-3-3proteinsigma,ZincfingerproteinGLI1 / Epithelial cell marker protein 1 / Stratifin / Glioma-associated oncogene / Oncogene GLI
Mass: 27810.104 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Details: Residues 75-77 were mutated to Alanines to reduce surface entropy and improve crystallization. Source: (gene. exp.) Homo sapiens (human) / Gene: SFN, HME1, GLI1, GLI / Production host: Escherichia coli (E. coli) / References: UniProt: P31947, UniProt: P08151
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