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Open data
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Basic information
Entry | Database: PDB / ID: 5oek | ||||||
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Title | Putative active dimeric state of GHR transmembrane domain | ||||||
![]() | Growth hormone receptor | ||||||
![]() | MEMBRANE PROTEIN / Dimer / GHR / Growth hormone receptor / Homodimer / Human / Receptor / Transmembrane domain / Tyrosine kinase | ||||||
Function / homology | ![]() growth hormone receptor activity / regulation of response to nutrient levels / growth hormone receptor complex / taurine metabolic process / response to gravity / cartilage development involved in endochondral bone morphogenesis / positive regulation of multicellular organism growth / hormone metabolic process / proline-rich region binding / response to food ...growth hormone receptor activity / regulation of response to nutrient levels / growth hormone receptor complex / taurine metabolic process / response to gravity / cartilage development involved in endochondral bone morphogenesis / positive regulation of multicellular organism growth / hormone metabolic process / proline-rich region binding / response to food / growth hormone receptor signaling pathway / response to cycloheximide / Prolactin receptor signaling / growth factor binding / cytokine binding / cell surface receptor signaling pathway via JAK-STAT / peptide hormone binding / regulation of multicellular organism growth / hormone-mediated signaling pathway / Growth hormone receptor signaling / response to glucocorticoid / positive regulation of tyrosine phosphorylation of STAT protein / cellular response to hormone stimulus / response to interleukin-1 / SH2 domain binding / insulin-like growth factor receptor signaling pathway / positive regulation of MAP kinase activity / positive regulation of cell differentiation / positive regulation of receptor signaling pathway via JAK-STAT / cellular response to insulin stimulus / receptor internalization / cytokine-mediated signaling pathway / cytoplasmic ribonucleoprotein granule / endocytosis / positive regulation of peptidyl-tyrosine phosphorylation / response to estradiol / protein phosphatase binding / receptor complex / external side of plasma membrane / neuronal cell body / lipid binding / protein kinase binding / cell surface / protein homodimerization activity / extracellular space / extracellular region / identical protein binding / membrane / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / torsion angle dynamics | ||||||
![]() | Lesovoy, D.M. / Bocharov, E.V. / Bocharova, O.V. / Urban, A.S. / Arseniev, A.S. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structural basis of the signal transduction via transmembrane domain of the human growth hormone receptor. Authors: Bocharov, E.V. / Lesovoy, D.M. / Bocharova, O.V. / Urban, A.S. / Pavlov, K.V. / Volynsky, P.E. / Efremov, R.G. / Arseniev, A.S. #1: Journal: Bioorg. Khim. / Year: 2015 Title: Preparation of Transmembrane Fragments Growth Hormone Receptor GHR in a Cell-Free Expression System for Structural Studies. Authors: Bocharova, O.V. / Kuzmichev, P.K. / Urban, A.S. / Goncharuk, S.A. / Bocharov, E.V. / Arsenyev, A.S. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 568.5 KB | Display | ![]() |
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PDB format | ![]() | 480.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 343.1 KB | Display | ![]() |
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Full document | ![]() | 603.9 KB | Display | |
Data in XML | ![]() | 27.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 5ohdC C: citing same article ( |
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Assembly
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 5145.129 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Details: The author sequence numbering corresponds to the Swiss-Prot annotation of the human Growth hormone receptor (GHR), P10912 Source: (gene. exp.) ![]() Production host: ![]() ![]() Strain (production host): BL21(DE3) / References: UniProt: P10912 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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