Entry Database : PDB / ID : 5o4l Structure visualization Downloads & linksTitle Crystal structure of P450 CYP121 in complex with compound 6a. ComponentsMycocyclosin synthase Details Keywords OXIDOREDUCTASE / Cytochrome P450 Redox InhibitorFunction / homology Function and homology informationFunction Domain/homology Component
mycocyclosin synthase / cholest-4-en-3-one 26-monooxygenase activity / steroid hydroxylase activity / cholesterol catabolic process / iron ion binding / heme binding / cytoplasm Similarity search - Function Cytochrome P450, B-class / Cytochrome p450 / Cytochrome P450 / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mycobacterium tuberculosis CDC1551 (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.64 Å DetailsAuthors Levy, C.W. CitationJournal : J. Med. Chem. / Year : 2017Title : Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.Authors: Taban, I.M. / Elshihawy, H.E.A.E. / Torun, B. / Zucchini, B. / Williamson, C.J. / Altuwairigi, D. / Ngu, A.S.T. / McLean, K.J. / Levy, C.W. / Sood, S. / Marino, L.B. / Munro, A.W. / de ... Authors : Taban, I.M. / Elshihawy, H.E.A.E. / Torun, B. / Zucchini, B. / Williamson, C.J. / Altuwairigi, D. / Ngu, A.S.T. / McLean, K.J. / Levy, C.W. / Sood, S. / Marino, L.B. / Munro, A.W. / de Carvalho, L.P.S. / Simons, C. History Deposition May 29, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 28, 2018 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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