Entry | Database: PDB / ID: 5nsk |
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Title | apo Structure of Leucyl aminopeptidase from Trypanosoma brucei |
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Components | Aminopeptidase, putative |
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Keywords | HYDROLASE / M17 leucyl aminopeptidase / aminopeptidase / tryanosoma brucei |
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Function / homology | Function and homology information
metalloaminopeptidase activity / aminopeptidase activity / peptidase activity / manganese ion binding / proteolysis / cytoplasmSimilarity search - Function Zn-dependent exopeptidases / Probable aminopeptidase NPEPL1, N-terminal / M17 aminopeptidase N-terminal domain 2 / Cytosol aminopeptidase signature. / Peptidase M17, leucyl aminopeptidase, C-terminal / Peptidase M17, leucine aminopeptidase/peptidase B / Cytosol aminopeptidase family, catalytic domain / Zn peptidases / Aminopeptidase / Rossmann fold ...Zn-dependent exopeptidases / Probable aminopeptidase NPEPL1, N-terminal / M17 aminopeptidase N-terminal domain 2 / Cytosol aminopeptidase signature. / Peptidase M17, leucyl aminopeptidase, C-terminal / Peptidase M17, leucine aminopeptidase/peptidase B / Cytosol aminopeptidase family, catalytic domain / Zn peptidases / Aminopeptidase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_eukaryote.gif) Trypanosoma brucei brucei TREU927 (eukaryote) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å |
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Authors | Timm, J. / Wilson, K.S. |
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Funding support | Spain, 5items Organization | Grant number | Country |
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European Commission | GA223238 | | European Commission | GA290080 | | RICET FIS Network | RD12/0018/0017 | Spain | Junta de Andalucia | BIO-199, P12-BIO-2059 | Spain | Plan Nacional | SAF2016-79957-R | Spain |
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Citation | Journal: mSphere / Year: 2018 Title: Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei. Authors: Timm, J. / Valente, M. / Garcia-Caballero, D. / Wilson, K.S. / Gonzalez-Pacanowska, D. |
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History | Deposition | Apr 26, 2017 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Aug 2, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 30, 2017 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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Revision 1.2 | Feb 21, 2018 | Group: Database references / Category: citation / Item: _citation.title |
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Revision 1.3 | Mar 28, 2018 | Group: Data collection / Database references / Category: citation / Item: _citation.title / _citation.year |
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Revision 1.4 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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