Entry Database : PDB / ID : 5naf Structure visualization Downloads & linksTitle Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain ComponentsF-box-like/WD repeat-containing protein TBL1XR1 Methyl-CpG-binding protein 2 DetailsKeywords TRANSCRIPTION / WD40 domain / protein-peptide complex / transcriptional repressor / Rett syndromeFunction / homology Function and homology informationFunction Domain/homology Component
: / : / : / : / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / : / Regulation of MECP2 expression and activity ... : / : / : / : / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / : / Regulation of MECP2 expression and activity / biogenic amine metabolic process / : / negative regulation of dendrite extension / cardiolipin metabolic process / : / regulation of triglyceride metabolic process / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / nervous system process involved in regulation of systemic arterial blood pressure / heterochromatin formation => GO:0031507 / proprioception / negative regulation of primary miRNA processing / : / negative regulation of smooth muscle cell differentiation / HDACs deacetylate histones / Notch-HLH transcription pathway / neuromuscular process controlling posture / negative regulation of dendritic spine development / blastocyst hatching / : / regulation of respiratory gaseous exchange by nervous system process / double-stranded methylated DNA binding / inositol metabolic process / : / phosphatidylcholine metabolic process / Regulation of lipid metabolism by PPARalpha / positive regulation of microtubule nucleation / glucocorticoid metabolic process / ventricular system development / cellular response to potassium ion / unmethylated CpG binding / positive regulation of synaptic plasticity / respiratory gaseous exchange by respiratory system / positive regulation of dendrite extension / response to other organism / siRNA binding / neuron maturation / methyl-CpG binding / fat pad development / neuromuscular process / positive regulation of dendritic spine development / regulation of synapse organization / glutamine metabolic process / startle response / dendrite development / response to dietary excess / social behavior / negative regulation of blood vessel endothelial cell migration / histone deacetylase complex / negative regulation of astrocyte differentiation / white fat cell differentiation / behavioral fear response / adipose tissue development / heterochromatin / multicellular organismal response to stress / long-term memory / lipid catabolic process / epigenetic regulation of gene expression / four-way junction DNA binding / sensory perception of pain / synapse assembly / positive regulation of G2/M transition of mitotic cell cycle / transcription repressor complex / excitatory postsynaptic potential / negative regulation of angiogenesis / adult locomotory behavior / cerebellum development / mitotic spindle organization / post-embryonic development / response to cocaine / learning / negative regulation of protein binding / promoter-specific chromatin binding / long-term synaptic potentiation / visual learning / regulation of synaptic plasticity / neuron differentiation / multicellular organism growth / protein localization / brain development / chromatin DNA binding / mitotic spindle / memory / beta-catenin binding / histone deacetylase binding / transcription corepressor activity / neuron projection development / positive regulation of canonical Wnt signaling pathway / histone binding / postsynapse / regulation of gene expression Similarity search - Function Methyl-CpG binding protein MeCP2 / LisH / : / Lissencephaly type-1-like homology motif / LIS1 homology (LisH) motif profile. / LIS1 homology motif / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. ... Methyl-CpG binding protein MeCP2 / LisH / : / Lissencephaly type-1-like homology motif / LIS1 homology (LisH) motif profile. / LIS1 homology motif / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.493 Å DetailsAuthors Kruusvee, V. / Cook, A.G. Funding support United Kingdom, 7items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) G1000520/1 United Kingdom Wellcome Trust 091580 United Kingdom Wellcome Trust 107930 United Kingdom Wellcome Trust 092076 United Kingdom Wellcome Trust 095822 United Kingdom Wellcome Trust 108504 United Kingdom Rett Syndrome Trust Grant to APB United Kingdom
CitationJournal : Proc. Natl. Acad. Sci. U.S.A. / Year : 2017Title : Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.Authors : Kruusvee, V. / Lyst, M.J. / Taylor, C. / Tarnauskaite, Z. / Bird, A.P. / Cook, A.G. History Deposition Feb 27, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 29, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Apr 5, 2017 Group : Database referencesRevision 1.2 Apr 26, 2017 Group : Database referencesRevision 1.3 Sep 13, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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