Entry Database : PDB / ID : 5mp0 Structure visualization Downloads & linksTitle Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain Componentsm7GpppN-mRNA hydrolase Details Keywords HYDROLASE / mRNA decapping / NudixFunction / homology Function and homology informationFunction Domain/homology Component
RNA exonuclease activity, producing 5'-phosphomonoesters / regulation of telomerase RNA localization to Cajal body / mRNA decay by 5' to 3' exoribonuclease / 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase / 5'-3' RNA exonuclease activity / 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity / : / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / ATF4 activates genes in response to endoplasmic reticulum stress / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA ... RNA exonuclease activity, producing 5'-phosphomonoesters / regulation of telomerase RNA localization to Cajal body / mRNA decay by 5' to 3' exoribonuclease / 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase / 5'-3' RNA exonuclease activity / 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity / : / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / ATF4 activates genes in response to endoplasmic reticulum stress / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / histone mRNA catabolic process / deadenylation-dependent decapping of nuclear-transcribed mRNA / telomerase RNA binding / negative regulation of telomere maintenance via telomerase / RISC complex / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / KSRP (KHSRP) binds and destabilizes mRNA / mRNA catabolic process / regulation of mRNA stability / P-body / cytoplasmic ribonucleoprotein granule / cell junction / manganese ion binding / nucleoplasm / cytosol / cytoplasm Similarity search - Function mRNA decapping protein 2, Box A domain / mRNA decapping protein 2, Box A domain superfamily / mRNA decapping enzyme 2 , NUDIX hydrolase domain / Dcp2, box A domain / Dcp2, box A domain / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain ... mRNA decapping protein 2, Box A domain / mRNA decapping protein 2, Box A domain superfamily / mRNA decapping enzyme 2 , NUDIX hydrolase domain / Dcp2, box A domain / Dcp2, box A domain / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.63 Å DetailsAuthors Mathea, S. / Salah, E. / Velupillai, S. / Tallant, C. / Pike, A.C.W. / Bushell, S.R. / Faust, B. / Wang, D. / Burgess-Brown, N. / von Delft, F. ...Mathea, S. / Salah, E. / Velupillai, S. / Tallant, C. / Pike, A.C.W. / Bushell, S.R. / Faust, B. / Wang, D. / Burgess-Brown, N. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Huber, K. CitationJournal : To Be Published Title : Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic DomainAuthors : Mathea, S. / Huber, K. History Deposition Dec 15, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 28, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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