Entry Database : PDB / ID : 5mkt Structure visualization Downloads & linksTitle Crystal structure of mouse prorenin ComponentsRenin-1 Details Keywords HYDROLASE / proreninFunction / homology Function and homology informationFunction Domain/homology Component
regulation of blood volume by renin-angiotensin / cellular response to xenobiotic stimulus => GO:0071466 / Metabolism of Angiotensinogen to Angiotensins / renin / response to xenobiotic stimulus => GO:0009410 / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade ... regulation of blood volume by renin-angiotensin / cellular response to xenobiotic stimulus => GO:0071466 / Metabolism of Angiotensinogen to Angiotensins / renin / response to xenobiotic stimulus => GO:0009410 / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / cell maturation / response to cAMP / hormone-mediated signaling pathway / : / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / apical part of cell / peptidase activity / endopeptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / membrane / cytoplasm Similarity search - Function Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.2 Å DetailsAuthors Yan, Y. / Read, R. Funding support United Kingdom, 2items Details Hide detailsOrganization Grant number Country Wellcome Trust 082961/Z/07/Z United Kingdom British Heart Foundation PG/12/41/29679 United Kingdom
CitationJournal : To Be Published Title : Crystal structure of mouse proreninAuthors : Yan, Y. / Zhou, A. / Read, R.J. History Deposition Dec 5, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 20, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / diffrn_radiation_wavelength ... chem_comp / diffrn_radiation_wavelength / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.2 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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