Entry Database : PDB / ID : 5lwv Structure visualization Downloads & linksTitle Human OGT in complex with UDP and fused substrate peptide (HCF1) ComponentsHost cell factor 1,UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Details Keywords TRANSFERASE / glycosylation / signalling / O-GlcNAc / O-GlcNAc transferase / substrate recognitionFunction / homology Function and homology informationFunction Domain/homology Component
protein N-acetylglucosaminyltransferase complex / protein O-GlcNAc transferase / release from viral latency / regulation of insulin receptor signaling pathway / protein O-acetylglucosaminyltransferase activity / positive regulation of transcription from RNA polymerase II promoter by glucose / acetylglucosaminyltransferase activity / regulation of necroptotic process / regulation of Rac protein signal transduction / negative regulation of stem cell population maintenance ... protein N-acetylglucosaminyltransferase complex / protein O-GlcNAc transferase / release from viral latency / regulation of insulin receptor signaling pathway / protein O-acetylglucosaminyltransferase activity / positive regulation of transcription from RNA polymerase II promoter by glucose / acetylglucosaminyltransferase activity / regulation of necroptotic process / regulation of Rac protein signal transduction / negative regulation of stem cell population maintenance / protein O-linked glycosylation / Set1C/COMPASS complex / MLL1/2 complex / NSL complex / regulation of glycolytic process / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / RIPK1-mediated regulated necrosis / regulation of synapse assembly / histone methyltransferase complex / regulation of gluconeogenesis / positive regulation of stem cell population maintenance / Formation of WDR5-containing histone-modifying complexes / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of proteolysis / mitophagy / hemopoiesis / MLL1 complex / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / histone acetyltransferase complex / regulation of protein-containing complex assembly / positive regulation of cell cycle / positive regulation of lipid biosynthetic process / negative regulation of protein ubiquitination / positive regulation of TORC1 signaling / negative regulation of cell migration / response to nutrient / cell projection / positive regulation of translation / mitochondrial membrane / cellular response to glucose stimulus / negative regulation of transforming growth factor beta receptor signaling pathway / circadian regulation of gene expression / response to insulin / Transcriptional activation of mitochondrial biogenesis / Regulation of necroptotic cell death / protein processing / chromatin DNA binding / UCH proteinases / chromatin organization / protein-macromolecule adaptor activity / positive regulation of cold-induced thermogenesis / HATs acetylate histones / DNA-binding transcription factor binding / transcription coactivator activity / protein stabilization / chromatin remodeling / cadherin binding / cell cycle / neuronal cell body / glutamatergic synapse / apoptotic process / chromatin binding / positive regulation of gene expression / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Host cell factor / Kelch motif / Galactose oxidase, central domain / O-GlcNAc transferase, C-terminal / Glycosyl transferase family 41 / TPR repeat / Tetratricopeptide repeat / Kelch repeat type 1 / Kelch motif / Tetratricopeptide repeat 1 ... Host cell factor / Kelch motif / Galactose oxidase, central domain / O-GlcNAc transferase, C-terminal / Glycosyl transferase family 41 / TPR repeat / Tetratricopeptide repeat / Kelch repeat type 1 / Kelch motif / Tetratricopeptide repeat 1 / Tetratricopeptide repeat / Kelch-type beta propeller / Tetratricopeptide repeat / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tetratricopeptide-like helical domain superfamily / Immunoglobulin-like fold Similarity search - Domain/homology PHOSPHATE ION / URIDINE-5'-DIPHOSPHATE / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / Host cell factor 1 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Raimi, O. / Rafie, K. / Kapuria, V. / Herr, W. / van Aalten, D. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Wellcome Trust 110061 United Kingdom
CitationJournal : Open Biol / Year : 2017Title : Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.Authors : Rafie, K. / Raimi, O. / Ferenbach, A.T. / Borodkin, V.S. / Kapuria, V. / van Aalten, D.M.F. History Deposition Sep 19, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 12, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / refine_hist Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.d_res_high
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