Entry Database : PDB / ID : 5l87 Structure visualization Downloads & linksTitle Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases. ComponentsPeroxin 14 Details Keywords MEMBRANE PROTEIN / trypanosomiasis / glycosome / protein-protein interaction inhibitor / structure-based drug discovery / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
glycosome membrane / peroxisomal importomer complex / protein import into peroxisome matrix, docking / protein targeting to vacuole / glycosome / post-transcriptional regulation of gene expression / signaling receptor binding Similarity search - Function Peroxisome membrane anchor protein Pex14p, N-terminal / Peroxisomal membrane protein 14 / Pex14 N-terminal domain / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Trypanosoma brucei brucei (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 0.87 Å DetailsAuthors Dawidowski, M. / Emmanouilidis, L. / Sattler, M. / Popowicz, G.M. Funding support Germany, 1items Details Hide detailsOrganization Grant number Country German Research Foundation FOR1905 ER178/4-1 Germany
CitationJournal : Science / Year : 2017Title : Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.Authors: Dawidowski, M. / Emmanouilidis, L. / Kalel, V.C. / Tripsianes, K. / Schorpp, K. / Hadian, K. / Kaiser, M. / Maser, P. / Kolonko, M. / Tanghe, S. / Rodriguez, A. / Schliebs, W. / Erdmann, R. ... Authors : Dawidowski, M. / Emmanouilidis, L. / Kalel, V.C. / Tripsianes, K. / Schorpp, K. / Hadian, K. / Kaiser, M. / Maser, P. / Kolonko, M. / Tanghe, S. / Rodriguez, A. / Schliebs, W. / Erdmann, R. / Sattler, M. / Popowicz, G.M. History Deposition Jun 7, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 8, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Apr 12, 2017 Group : Database referencesRevision 1.2 Oct 16, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / reflns_shell / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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