Entry Database : PDB / ID : 5ks8 Structure visualization Downloads & linksTitle Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus ComponentsPyruvate carboxylase subunit alpha Pyruvate carboxylase subunit beta DetailsKeywords LIGASE / Biotin / TIM Barrel / PyruvateFunction / homology Function and homology informationFunction Domain/homology Component
acetyl-CoA carboxylase / biotin carboxylase / oxaloacetate decarboxylase activity / biotin carboxylase activity / malonyl-CoA biosynthetic process / acetyl-CoA carboxylase activity / sodium ion transport / fatty acid biosynthetic process / ATP binding / metal ion binding Similarity search - Function Oxaloacetate decarboxylase, alpha subunit / Acetyl-CoA carboxylase, biotin carboxylase / Carboxylase, conserved domain / Conserved carboxylase domain / Pyruvate carboxyltransferase / HMGL-like / Pyruvate carboxyltransferase domain. / Biotin-binding site / Biotin-requiring enzymes attachment site. / Biotin carboxylase-like, N-terminal domain ... Oxaloacetate decarboxylase, alpha subunit / Acetyl-CoA carboxylase, biotin carboxylase / Carboxylase, conserved domain / Conserved carboxylase domain / Pyruvate carboxyltransferase / HMGL-like / Pyruvate carboxyltransferase domain. / Biotin-binding site / Biotin-requiring enzymes attachment site. / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain / Biotin carboxylation domain profile. / Biotin carboxylase C-terminal domain / Carbamoyl-phosphate synthase subdomain signature 1. / Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain / Carbamoyl-phosphate synthase L chain, ATP binding domain / Biotin-requiring enzyme / Rudiment single hybrid motif / Biotinyl/lipoyl domain profile. / Biotin/lipoyl attachment / Single hybrid motif / ATP-grasp fold, B domain / Pre-ATP-grasp domain superfamily / ATP-grasp fold / ATP-grasp fold profile. / D-amino Acid Aminotransferase; Chain A, domain 1 / Carbamoyl-phosphate synthase subdomain signature 2. / Aldolase-type TIM barrel / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Methylobacillus flagellatus (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.01 Å DetailsAuthors Choi, P.H. / Tong, L. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) DK067238 United States National Institutes of Health/Office of the Director OD012018 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI103369 United States
CitationJournal : Nat Commun / Year : 2016Title : A distinct holoenzyme organization for two-subunit pyruvate carboxylase.Authors : Choi, P.H. / Jo, J. / Lin, Y.C. / Lin, M.H. / Chou, C.Y. / Dietrich, L.E. / Tong, L. History Deposition Jul 7, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 19, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2017 Group : Derived calculations / Refinement description / Category : pdbx_struct_oper_list / softwareItem : _pdbx_struct_oper_list.symmetry_operation / _software.nameRevision 1.2 Mar 23, 2022 Group : Author supporting evidence / Data collection ... Author supporting evidence / Data collection / Database references / Derived calculations Category : database_2 / diffrn_radiation_wavelength ... database_2 / diffrn_radiation_wavelength / pdbx_audit_support / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id Revision 2.0 Nov 15, 2023 Group : Atomic model / Data collection / Refinement descriptionCategory : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / struct_ncs_dom_lim Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id Revision 2.1 Apr 3, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
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