Entry Database : PDB / ID : 5k13 Structure visualization Downloads & linksTitle Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist ComponentsRetinoic acid receptor alpha Details Keywords TRANSCRIPTION / NHR ligand-binding domain / antagonistFunction / homology Function and homology informationFunction Domain/homology Component
Sertoli cell fate commitment / positive regulation of binding / trachea cartilage development / ventricular cardiac muscle cell differentiation / embryonic camera-type eye development / chondroblast differentiation / glandular epithelial cell development / negative regulation of granulocyte differentiation / protein kinase B binding / cellular response to corticotropin-releasing hormone stimulus ... Sertoli cell fate commitment / positive regulation of binding / trachea cartilage development / ventricular cardiac muscle cell differentiation / embryonic camera-type eye development / chondroblast differentiation / glandular epithelial cell development / negative regulation of granulocyte differentiation / protein kinase B binding / cellular response to corticotropin-releasing hormone stimulus / growth plate cartilage development / positive regulation of T-helper 2 cell differentiation / prostate gland development / negative regulation of cartilage development / retinoic acid-responsive element binding / regulation of hematopoietic progenitor cell differentiation / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / nuclear glucocorticoid receptor binding / retinoic acid binding / response to vitamin A / apoptotic cell clearance / limb development / regulation of myelination / protein kinase A binding / ureteric bud development / Signaling by Retinoic Acid / DNA-binding transcription repressor activity / heterocyclic compound binding / positive regulation of interleukin-4 production / face development / alpha-actinin binding / germ cell development / negative regulation of type II interferon production / negative regulation of tumor necrosis factor production / retinoic acid receptor signaling pathway / cellular response to estrogen stimulus / positive regulation of cell cycle / cellular response to retinoic acid / response to retinoic acid / positive regulation of neuron differentiation / hormone-mediated signaling pathway / mRNA regulatory element binding translation repressor activity / negative regulation of miRNA transcription / liver development / response to cytokine / neural tube closure / female pregnancy / hippocampus development / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / regulation of synaptic plasticity / multicellular organism growth / chromatin DNA binding / mRNA 5'-UTR binding / transcription coactivator binding / histone deacetylase binding / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Nuclear Receptor transcription pathway / Transcriptional regulation of granulopoiesis / RNA polymerase II transcription regulator complex / nuclear receptor activity / sequence-specific double-stranded DNA binding / actin cytoskeleton / response to estradiol / cellular response to lipopolysaccharide / regulation of apoptotic process / response to ethanol / transcription regulator complex / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / protein domain specific binding / protein phosphorylation / signaling receptor binding / negative regulation of DNA-templated transcription / chromatin binding / dendrite / positive regulation of cell population proliferation / chromatin / nucleolus / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function : / : / Retinoic acid receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. ... : / : / Retinoic acid receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.85 Å DetailsAuthors Wang, Y. / Stout, S.L. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2016Title : Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design.Authors: Hughes, N.E. / Bleisch, T.J. / Jones, S.A. / Richardson, T.I. / Doti, R.A. / Wang, Y. / Stout, S.L. / Durst, G.L. / Chambers, M.G. / Oskins, J.L. / Lin, C. / Adams, L.A. / Page, T.J. / Barr, ... Authors : Hughes, N.E. / Bleisch, T.J. / Jones, S.A. / Richardson, T.I. / Doti, R.A. / Wang, Y. / Stout, S.L. / Durst, G.L. / Chambers, M.G. / Oskins, J.L. / Lin, C. / Adams, L.A. / Page, T.J. / Barr, R.J. / Zink, R.W. / Osborne, H. / Montrose-Rafizadeh, C. / Norman, B.H. History Deposition May 17, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 22, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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