- PDB-5ieq: Crystal structure of polymerase acid protein (PA) from Influenza ... -
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基本情報
登録情報
データベース: PDB / ID: 5ieq
タイトル
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole
要素
Polymerase acidic protein
キーワード
VIRAL PROTEIN / NIAID / structural genomics / fragment screening / STD NMR / fragments of life / flu / Seattle Structural Genomics Center for Infectious Disease / SSGCID
機能・相同性
機能・相同性情報
RNA polymerase activity / negative regulation of viral transcription / negative stranded viral RNA replication / negative regulation of viral genome replication / cap snatching / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / protein import into nucleus / endonuclease activity / host cell cytoplasm / 加水分解酵素; エステル加水分解酵素 ...RNA polymerase activity / negative regulation of viral transcription / negative stranded viral RNA replication / negative regulation of viral genome replication / cap snatching / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / protein import into nucleus / endonuclease activity / host cell cytoplasm / 加水分解酵素; エステル加水分解酵素 / DNA-templated transcription / host cell nucleus / RNA binding / metal ion binding 類似検索 - 分子機能
Polymerase acidic protein / Influenza RNA-dependent RNA polymerase subunit PA / Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain / Influenza RNA-dependent RNA polymerase subunit PA 類似検索 - ドメイン・相同性
1-(4-CHLOROPHENYL)-1H-IMIDAZOLE / Polymerase acidic protein 類似検索 - 構成要素
温度: 289 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 7.5 詳細: 20 mg/mL protein against Morpheus H6, 10% PEG 8000, 20% EG, 0.02 M each amino acid, 0.1 M MOPS/Hepes pH 7.5, crystal ID 254835h6, unique puck ID fhx2-7