登録情報 | データベース: PDB / ID: 5i22 |
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タイトル | Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide |
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要素 | - CHIKV nsP3 peptide
- Myc box-dependent-interacting protein 1
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キーワード | TRANSCRIPTION / SH3 domain / function: protein binding Chikungunya virus nsP3 peptide / function: viral replication |
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機能・相同性 | 機能・相同性情報
lipid tube / negative regulation of ventricular cardiac muscle cell action potential / negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / lipid tube assembly / RNA polymerase II transcription repressor complex / regulation of cell cycle process / T-tubule organization / negative regulation of potassium ion transmembrane transport / varicosity ...lipid tube / negative regulation of ventricular cardiac muscle cell action potential / negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / lipid tube assembly / RNA polymerase II transcription repressor complex / regulation of cell cycle process / T-tubule organization / negative regulation of potassium ion transmembrane transport / varicosity / extrinsic component of synaptic vesicle membrane / nucleus localization / cerebellar mossy fiber / axon initial segment / positive regulation of astrocyte differentiation / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / aspartic-type endopeptidase inhibitor activity / mRNA methyltransferase activity / mRNA 5'-triphosphate monophosphatase activity / node of Ranvier / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / I band / RNA polymerase binding / regulation of neuron differentiation / clathrin binding / positive regulation of actin filament polymerization / nucleus organization / endosome to lysosome transport / regulation of cytoskeleton organization / regulation of heart rate by cardiac conduction / negative regulation of amyloid-beta formation / positive regulation of endocytosis / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / synaptic vesicle endocytosis / 7-methylguanosine mRNA capping / axon terminus / cysteine-type peptidase activity / cytoskeleton organization / T-tubule / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / host cell cytoplasmic vesicle membrane / tau protein binding / phospholipid binding / Z disc / endocytosis / actin filament binding / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / actin cytoskeleton / synaptic vesicle / nucleoside-triphosphate phosphatase / GTPase binding / Clathrin-mediated endocytosis / nuclear envelope / protein-folding chaperone binding / protease binding / vesicle / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / RNA helicase activity / endosome / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / RNA helicase / positive regulation of apoptotic process / RNA-directed RNA polymerase / axon / viral RNA genome replication / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / glutamatergic synapse / dendrite / host cell nucleus / GTP binding / host cell plasma membrane / negative regulation of transcription by RNA polymerase II / ATP hydrolysis activity / proteolysis / RNA binding / ATP binding / identical protein binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Amphiphysin 2 / Amphiphysin 2, SH3 domain / Amphiphysin / BAR domain / BAR domain profile. / BAR / BAR domain / : / : / : ...Amphiphysin 2 / Amphiphysin 2, SH3 domain / Amphiphysin / BAR domain / BAR domain profile. / BAR / BAR domain / : / : / : / Non-structural protein 3, zinc-binding domain / Tomato mosaic virus helicase, N-terminal domain / Alphavirus nsP2 protease domain superfamily / Alphavirus nsp2 protease (nsp2pro) domain / Peptidase family C9 / Alphavirus nsp2 protease (nsp2pro) domain profile. / Viral methyltransferase / Alphavirus-like methyltransferase (MT) domain / Alphavirus-like methyltransferase (MT) domain profile. / Tymovirus, RNA-dependent RNA polymerase / RNA dependent RNA polymerase / AH/BAR domain superfamily / Variant SH3 domain / Viral (Superfamily 1) RNA helicase / SH3 Domains / SH3 type barrels. / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / (+) RNA virus helicase core domain / (+)RNA virus helicase core domain profile. / Non-structural protein 3, X-domain-like / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / Roll / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 Myc box-dependent-interacting protein 1 / Polyprotein P1234類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_virus.gif) Chikungunya virus (チクングニヤウイルス) |
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手法 | 溶液NMR |
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データ登録者 | Tossavainen, H. / Aitio, O. / Hellman, M. / Saksela, K. / Permi, P. |
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資金援助 | フィンランド, 1件 組織 | 認可番号 | 国 |
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Academy of Finland | | フィンランド |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2016 タイトル: Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2. 著者: Tossavainen, H. / Aitio, O. / Hellman, M. / Saksela, K. / Permi, P. |
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履歴 | 登録 | 2016年2月4日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2016年6月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年6月22日 | Group: Database references |
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改定 1.2 | 2016年8月10日 | Group: Database references |
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改定 1.3 | 2019年5月8日 | Group: Data collection / カテゴリ: pdbx_nmr_software / Item: _pdbx_nmr_software.name |
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改定 1.4 | 2019年10月23日 | Group: Data collection / Experimental preparation / カテゴリ: pdbx_nmr_exptl_sample_conditions Item: _pdbx_nmr_exptl_sample_conditions.temperature / _pdbx_nmr_exptl_sample_conditions.temperature_units |
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改定 1.5 | 2024年6月19日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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