Entry Database : PDB / ID : 5i22 Structure visualization Downloads & linksTitle Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide ComponentsCHIKV nsP3 peptide Myc box-dependent-interacting protein 1 DetailsKeywords TRANSCRIPTION / SH3 domain / function: protein binding Chikungunya virus nsP3 peptide / function: viral replicationFunction / homology Function and homology informationFunction Domain/homology Component
lipid tube / negative regulation of ventricular cardiac muscle cell action potential / negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / lipid tube assembly / RNA polymerase II transcription repressor complex / regulation of cell cycle process / T-tubule organization / negative regulation of potassium ion transmembrane transport / varicosity ... lipid tube / negative regulation of ventricular cardiac muscle cell action potential / negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / lipid tube assembly / RNA polymerase II transcription repressor complex / regulation of cell cycle process / T-tubule organization / negative regulation of potassium ion transmembrane transport / varicosity / extrinsic component of synaptic vesicle membrane / axon initial segment / nucleus localization / cerebellar mossy fiber / positive regulation of astrocyte differentiation / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / aspartic-type endopeptidase inhibitor activity / mRNA methyltransferase activity / node of Ranvier / mRNA 5'-triphosphate monophosphatase activity / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / I band / RNA polymerase binding / regulation of neuron differentiation / clathrin binding / positive regulation of actin filament polymerization / nucleus organization / endosome to lysosome transport / regulation of cytoskeleton organization / regulation of heart rate by cardiac conduction / negative regulation of amyloid-beta formation / positive regulation of endocytosis / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / synaptic vesicle endocytosis / 7-methylguanosine mRNA capping / axon terminus / cysteine-type peptidase activity / cytoskeleton organization / T-tubule / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / Transferases; Transferring one-carbon groups; Methyltransferases / host cell cytoplasmic vesicle membrane / tau protein binding / phospholipid binding / Z disc / endocytosis / actin filament binding / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / actin cytoskeleton / synaptic vesicle / nucleoside-triphosphate phosphatase / GTPase binding / Clathrin-mediated endocytosis / nuclear envelope / protein-folding chaperone binding / protease binding / vesicle / Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases / RNA helicase activity / endosome / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / RNA helicase / positive regulation of apoptotic process / RNA-directed RNA polymerase / axon / viral RNA genome replication / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / glutamatergic synapse / dendrite / host cell nucleus / GTP binding / host cell plasma membrane / negative regulation of transcription by RNA polymerase II / ATP hydrolysis activity / proteolysis / RNA binding / ATP binding / identical protein binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Amphiphysin 2 / Amphiphysin 2, SH3 domain / Amphiphysin / BAR domain / BAR domain profile. / BAR / BAR domain / : / : / : ... Amphiphysin 2 / Amphiphysin 2, SH3 domain / Amphiphysin / BAR domain / BAR domain profile. / BAR / BAR domain / : / : / : / Non-structural protein 3, zinc-binding domain / Tomato mosaic virus helicase, N-terminal domain / Alphavirus nsP2 protease domain superfamily / Alphavirus nsp2 protease (nsp2pro) domain / Peptidase family C9 / Alphavirus nsp2 protease (nsp2pro) domain profile. / Viral methyltransferase / Alphavirus-like methyltransferase (MT) domain / Alphavirus-like methyltransferase (MT) domain profile. / Tymovirus, RNA-dependent RNA polymerase / RNA dependent RNA polymerase / AH/BAR domain superfamily / Variant SH3 domain / Viral (Superfamily 1) RNA helicase / SH3 Domains / SH3 type barrels. / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / (+) RNA virus helicase core domain / (+)RNA virus helicase core domain profile. / Non-structural protein 3, X-domain-like / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / Roll / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human) Chikungunya virusMethod SOLUTION NMR DetailsAuthors Tossavainen, H. / Aitio, O. / Hellman, M. / Saksela, K. / Permi, P. Funding support Finland, 1items Details Hide detailsOrganization Grant number Country Academy of Finland Finland
CitationJournal : J.Biol.Chem. / Year : 2016Title : Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2.Authors : Tossavainen, H. / Aitio, O. / Hellman, M. / Saksela, K. / Permi, P. History Deposition Feb 4, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jun 15, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jun 22, 2016 Group : Database referencesRevision 1.2 Aug 10, 2016 Group : Database referencesRevision 1.3 May 8, 2019 Group : Data collection / Category : pdbx_nmr_software / Item : _pdbx_nmr_software.nameRevision 1.4 Oct 23, 2019 Group : Data collection / Experimental preparation / Category : pdbx_nmr_exptl_sample_conditionsItem : _pdbx_nmr_exptl_sample_conditions.temperature / _pdbx_nmr_exptl_sample_conditions.temperature_unitsRevision 1.5 Jun 19, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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