Entry Database : PDB / ID : 5hh4 Structure visualization Downloads & linksTitle Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor ComponentsBeta-lactamase IMP-1 Details Keywords HYDROLASE / inhibitor / carbapenamase / pyridine / phosphonate / antibiotic resistanceFunction / homology Function and homology informationFunction Domain/homology Component
antibiotic catabolic process / beta-lactamase activity / beta-lactamase / periplasmic space / response to antibiotic / zinc ion binding Similarity search - Function Beta-lactamases class B signature 2. / Beta-lactamases class B signature 1. / Beta-lactamase, class-B, conserved site / Metallo-beta-lactamase superfamily / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / Metallo-beta-lactamase; Chain A / Metallo-beta-lactamase superfamily / Metallo-beta-lactamase / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / 4-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Serratia marcescens (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Hinchliffe, P. / Spencer, J. Funding support United Kingdom, United States, 2items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) G1100135 United Kingdom National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01AI100560 United States
CitationJournal : Biochemistry / Year : 2018Title : Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.Authors: Hinchliffe, P. / Tanner, C.A. / Krismanich, A.P. / Labbe, G. / Goodfellow, V.J. / Marrone, L. / Desoky, A.Y. / Calvopina, K. / Whittle, E.E. / Zeng, F. / Avison, M.B. / Bols, N.C. / Siemann, ... Authors : Hinchliffe, P. / Tanner, C.A. / Krismanich, A.P. / Labbe, G. / Goodfellow, V.J. / Marrone, L. / Desoky, A.Y. / Calvopina, K. / Whittle, E.E. / Zeng, F. / Avison, M.B. / Bols, N.C. / Siemann, S. / Spencer, J. / Dmitrienko, G.I. History Deposition Jan 9, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jan 18, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Sep 13, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Feb 27, 2019 Group : Data collection / Database referencesCategory : citation / citation_author ... citation / citation_author / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.3 Mar 30, 2022 Group : Author supporting evidence / Database references / Derived calculationsCategory : database_2 / pdbx_audit_support ... database_2 / pdbx_audit_support / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id Revision 1.4 Jan 10, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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