登録情報 データベース : PDB / ID : 5he5 構造の表示 ダウンロードとリンクタイトル BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium 要素Beta-secretase 1 詳細 キーワード HYDROLASE/HYDROLASE INHIBITOR / ALZHEIMER'S / ASPARTYL PROTEASE / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / detection of mechanical stimulus involved in sensory perception of pain / cellular response to manganese ion / amyloid-beta metabolic process ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / detection of mechanical stimulus involved in sensory perception of pain / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / positive regulation of neuron apoptotic process / cellular response to amyloid-beta / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / lysosome / early endosome / aspartic-type endopeptidase activity / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性 Chem-60S / L(+)-TARTARIC ACID / Beta-secretase 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.55 Å 詳細データ登録者 Orth, P. 引用ジャーナル : J.Med.Chem. / 年 : 2016タイトル : Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates.著者: Mandal, M. / Wu, Y. / Misiaszek, J. / Li, G. / Buevich, A. / Caldwell, J.P. / Liu, X. / Mazzola, R.D. / Orth, P. / Strickland, C. / Voigt, J. / Wang, H. / Zhu, Z. / Chen, X. / Grzelak, M. / ... 著者 : Mandal, M. / Wu, Y. / Misiaszek, J. / Li, G. / Buevich, A. / Caldwell, J.P. / Liu, X. / Mazzola, R.D. / Orth, P. / Strickland, C. / Voigt, J. / Wang, H. / Zhu, Z. / Chen, X. / Grzelak, M. / Hyde, L.A. / Kuvelkar, R. / Leach, P.T. / Terracina, G. / Zhang, L. / Zhang, Q. / Michener, M.S. / Smith, B. / Cox, K. / Grotz, D. / Favreau, L. / Mitra, K. / Kazakevich, I. / McKittrick, B.A. / Greenlee, W. / Kennedy, M.E. / Parker, E.M. / Cumming, J.N. / Stamford, A.W. 履歴 登録 2016年1月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年3月16日 Provider : repository / タイプ : Initial release改定 1.1 2016年4月27日 Group : Database references改定 1.2 2024年10月16日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_entry_details / pdbx_modification_feature / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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