登録情報 | データベース: PDB / ID: 5gnv |
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タイトル | Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain |
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要素 | - Disks large homolog 4
- Microtubule-associated protein 1A
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キーワード | PEPTIDE BINDING PROTEIN / binding-induced folding |
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機能・相同性 | 機能・相同性情報
primary dendrite / dendritic microtubule / regulation of microtubule depolymerization / retrograde axonal protein transport / negative regulation of protein localization to microtubule / RHO GTPases activate CIT / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins ...primary dendrite / dendritic microtubule / regulation of microtubule depolymerization / retrograde axonal protein transport / negative regulation of protein localization to microtubule / RHO GTPases activate CIT / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins / beta-1 adrenergic receptor binding / anterograde axonal protein transport / neuroligin family protein binding / structural constituent of postsynaptic density / proximal dendrite / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / embryo development / axon initial segment / receptor localization to synapse / voluntary musculoskeletal movement / cerebellar mossy fiber / cellular response to potassium ion / protein localization to synapse / vocalization behavior / cytoskeletal anchor activity / LGI-ADAM interactions / Trafficking of AMPA receptors / dendritic branch / neuron spine / Activation of Ca-permeable Kainate Receptor / negative regulation of microtubule depolymerization / AMPA glutamate receptor clustering / positive regulation of protein localization to cell surface / juxtaparanode region of axon / photoreceptor cell maintenance / dendritic spine morphogenesis / frizzled binding / negative regulation of receptor internalization / dendritic spine organization / neuron projection terminus / acetylcholine receptor binding / postsynaptic neurotransmitter receptor diffusion trapping / establishment or maintenance of epithelial cell apical/basal polarity / positive regulation of synapse assembly / Synaptic adhesion-like molecules / regulation of NMDA receptor activity / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of dendrite morphogenesis / microtubule associated complex / positive regulation of protein localization / cortical cytoskeleton / dendrite development / locomotory exploration behavior / regulation of neuronal synaptic plasticity / kinesin binding / associative learning / positive regulation of excitatory postsynaptic potential / social behavior / AMPA glutamate receptor complex / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein tyrosine kinase activity / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / photoreceptor outer segment / D1 dopamine receptor binding / Unblocking of NMDA receptors, glutamate binding and activation / glutamate receptor binding / positive regulation of synaptic transmission / beta-2 adrenergic receptor binding / axon cytoplasm / extrinsic component of cytoplasmic side of plasma membrane / collagen binding / neuron projection maintenance / dendrite cytoplasm / tubulin binding / axonogenesis / dendritic shaft / synaptic membrane / cell periphery / PDZ domain binding / sensory perception of sound / postsynaptic density membrane / regulation of long-term neuronal synaptic plasticity / ionotropic glutamate receptor binding / regulation of synaptic plasticity / establishment of protein localization / neuromuscular junction / cerebral cortex development / memory / kinase binding / cell-cell adhesion / microtubule cytoskeleton organization / neuron cellular homeostasis / cell-cell junction / synaptic vesicle / cell junction / actin binding類似検索 - 分子機能 Microtubule associated protein 1A / Microtubule associated protein 1 / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. ...Microtubule associated protein 1A / Microtubule associated protein 1 / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Disks large homolog 4 / Microtubule-associated protein 1A類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.596 Å |
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データ登録者 | Shang, Y. / Xia, Y. / Zhu, R. / Zhu, J. |
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資金援助 | 中国, 3件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China | 31470733 | 中国 | the Shanghai YangFan Plan for Young Scientists | 14YF1406700 | 中国 | the SIBS Frontier Science Program for talented young scientists | 2014KIP101 | 中国 |
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引用 | ジャーナル: Biochem. J. / 年: 2017 タイトル: Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain 著者: Xia, Y. / Shang, Y. / Zhang, R. / Zhu, J. |
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履歴 | 登録 | 2016年7月25日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2017年8月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2024年3月20日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_special_symmetry Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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