Entry Database : PDB / ID : 5gnv Structure visualization Downloads & linksTitle Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain ComponentsDisks large homolog 4 Microtubule-associated protein 1A DetailsKeywords PEPTIDE BINDING PROTEIN / binding-induced foldingFunction / homology Function and homology informationFunction Domain/homology Component
primary dendrite / dendritic microtubule / regulation of microtubule depolymerization / retrograde axonal protein transport / negative regulation of protein localization to microtubule / RHO GTPases activate CIT / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins ... primary dendrite / dendritic microtubule / regulation of microtubule depolymerization / retrograde axonal protein transport / negative regulation of protein localization to microtubule / RHO GTPases activate CIT / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins / beta-1 adrenergic receptor binding / anterograde axonal protein transport / neuroligin family protein binding / structural constituent of postsynaptic density / proximal dendrite / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / embryo development / axon initial segment / receptor localization to synapse / voluntary musculoskeletal movement / cerebellar mossy fiber / cellular response to potassium ion / protein localization to synapse / vocalization behavior / cytoskeletal anchor activity / LGI-ADAM interactions / Trafficking of AMPA receptors / dendritic branch / neuron spine / Activation of Ca-permeable Kainate Receptor / negative regulation of microtubule depolymerization / AMPA glutamate receptor clustering / positive regulation of protein localization to cell surface / juxtaparanode region of axon / photoreceptor cell maintenance / dendritic spine morphogenesis / frizzled binding / negative regulation of receptor internalization / dendritic spine organization / neuron projection terminus / acetylcholine receptor binding / postsynaptic neurotransmitter receptor diffusion trapping / establishment or maintenance of epithelial cell apical/basal polarity / positive regulation of synapse assembly / Synaptic adhesion-like molecules / regulation of NMDA receptor activity / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of dendrite morphogenesis / microtubule associated complex / positive regulation of protein localization / cortical cytoskeleton / dendrite development / locomotory exploration behavior / regulation of neuronal synaptic plasticity / kinesin binding / associative learning / positive regulation of excitatory postsynaptic potential / social behavior / AMPA glutamate receptor complex / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein tyrosine kinase activity / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / photoreceptor outer segment / D1 dopamine receptor binding / Unblocking of NMDA receptors, glutamate binding and activation / glutamate receptor binding / positive regulation of synaptic transmission / beta-2 adrenergic receptor binding / axon cytoplasm / extrinsic component of cytoplasmic side of plasma membrane / collagen binding / neuron projection maintenance / dendrite cytoplasm / tubulin binding / axonogenesis / dendritic shaft / synaptic membrane / cell periphery / PDZ domain binding / sensory perception of sound / postsynaptic density membrane / regulation of long-term neuronal synaptic plasticity / ionotropic glutamate receptor binding / regulation of synaptic plasticity / establishment of protein localization / neuromuscular junction / cerebral cortex development / memory / kinase binding / cell-cell adhesion / microtubule cytoskeleton organization / neuron cellular homeostasis / cell-cell junction / synaptic vesicle / cell junction / actin binding Similarity search - Function Microtubule associated protein 1A / Microtubule associated protein 1 / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. ... Microtubule associated protein 1A / Microtubule associated protein 1 / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.596 Å DetailsAuthors Shang, Y. / Xia, Y. / Zhu, R. / Zhu, J. Funding support China, 3items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31470733 China the Shanghai YangFan Plan for Young Scientists 14YF1406700 China the SIBS Frontier Science Program for talented young scientists 2014KIP101 China
CitationJournal : Biochem. J. / Year : 2017Title : Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domainAuthors : Xia, Y. / Shang, Y. / Zhang, R. / Zhu, J. History Deposition Jul 25, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Aug 2, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Nov 1, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name Revision 1.2 Mar 20, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_special_symmetry Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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