Entry Database : PDB / ID : 5fw6 Structure visualization Downloads & linksTitle Structure of human transthyretin mutant A108V ComponentsTRANSTHYRETIN Details Keywords TRANSPORT PROTEIN / TRASNPORT PROTEIN / T4-BINDING / T4-BINDING PROTEIN NON-AMYLOIDOGENICFunction / homology Function and homology informationFunction Domain/homology Component
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ... Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ... Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.3 Å DetailsAuthors Gallego, P. / Varejao, N. / Santanna, R. / Saraiva, M.J. / Ventura, S. / Reverter, D. CitationJournal : Sci Rep / Year : 2017Title : Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.Authors : Sant'Anna, R. / Almeida, M.R. / Varejao, N. / Gallego, P. / Esperante, S. / Ferreira, P. / Pereira-Henriques, A. / Palhano, F.L. / de Carvalho, M. / Foguel, D. / Reverter, D. / Saraiva, M.J. / Ventura, S. History Deposition Feb 12, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 8, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jun 14, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 May 8, 2024 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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