登録情報 | データベース: PDB / ID: 5ekn |
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タイトル | Crystal structure of MAPK13 complex with inhibitor |
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要素 | Mitogen-activated protein kinase 13 |
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キーワード | Transferase/Transferase Inhibitor / KINASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
cellular response to anisomycin / cellular response to sorbitol / cellular response to sodium arsenite / response to osmotic stress / cellular response to interleukin-1 / MAP kinase activity / mitogen-activated protein kinase / stress-activated MAPK cascade / p38MAPK events / NOD1/2 Signaling Pathway ...cellular response to anisomycin / cellular response to sorbitol / cellular response to sodium arsenite / response to osmotic stress / cellular response to interleukin-1 / MAP kinase activity / mitogen-activated protein kinase / stress-activated MAPK cascade / p38MAPK events / NOD1/2 Signaling Pathway / VEGFA-VEGFR2 Pathway / positive regulation of interleukin-6 production / cellular response to hydrogen peroxide / positive regulation of inflammatory response / cellular response to UV / peptidyl-serine phosphorylation / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Mitogen-activated protein kinase 13 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain ...Mitogen-activated protein kinase 13 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-N58 / Mitogen-activated protein kinase 13類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.594 Å |
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データ登録者 | Brett, T.J. / Miller, C.A. / Yurtsever, Z. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | R01-HL119813 | 米国 |
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引用 | ジャーナル: Biochim.Biophys.Acta / 年: 2016 タイトル: First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. 著者: Yurtsever, Z. / Patel, D.A. / Kober, D.L. / Su, A. / Miller, C.A. / Romero, A.G. / Holtzman, M.J. / Brett, T.J. |
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履歴 | 登録 | 2015年11月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年7月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年7月20日 | Group: Database references |
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改定 1.2 | 2016年9月14日 | Group: Database references |
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改定 1.3 | 2017年9月20日 | Group: Author supporting evidence / Database references / Derived calculations カテゴリ: citation / pdbx_audit_support / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.4 | 2017年11月1日 | Group: Author supporting evidence / カテゴリ: pdbx_struct_assembly_auth_evidence |
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改定 1.5 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.6 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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