Entry | Database: PDB / ID: 5eh1 |
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Title | Crystal structure of the extracellular part of receptor 2 of human interferon gamma |
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Components | Interferon gamma receptor 2 |
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Keywords | CYTOKINE / interferon gamma / immunity / fibronectin III domain |
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Function / homology | Function and homology information
type II interferon receptor activity / type III interferon-mediated signaling pathway / cytokine receptor activity / IFNG signaling activates MAPKs / Regulation of IFNG signaling / type II interferon-mediated signaling pathway / microglial cell activation / response to virus / cytoplasmic vesicle membrane / cellular response to virus ...type II interferon receptor activity / type III interferon-mediated signaling pathway / cytokine receptor activity / IFNG signaling activates MAPKs / Regulation of IFNG signaling / type II interferon-mediated signaling pathway / microglial cell activation / response to virus / cytoplasmic vesicle membrane / cellular response to virus / cytokine-mediated signaling pathway / Interferon gamma signaling / defense response to virus / Potential therapeutics for SARS / cell surface receptor signaling pathway / Golgi membrane / endoplasmic reticulum membrane / endoplasmic reticulum / plasma membraneSimilarity search - Function Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.8 Å |
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Authors | Kolenko, P. / Mikulecky, P. / Zahradnik, J. / Dohnalek, J. / Koval, T. / Cerny, J. / Necasova, I. / Schneider, B. |
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Citation | Journal: Acta Crystallogr D Struct Biol / Year: 2016 Title: Crystal structure of human interferon-gamma receptor 2 reveals the structural basis for receptor specificity. Authors: Mikulecky, P. / Zahradnik, J. / Kolenko, P. / Cerny, J. / Charnavets, T. / Kolarova, L. / Necasova, I. / Pham, P.N. / Schneider, B. |
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History | Deposition | Oct 27, 2015 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Aug 17, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 14, 2016 | Group: Database references |
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Revision 1.2 | Apr 18, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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Revision 1.3 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_special_symmetry / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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