Entry Database : PDB / ID : 5dwq Structure visualization Downloads & linksTitle Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) ComponentsHistone-arginine methyltransferase CARM1 methylated H3 peptide DetailsKeywords TRANSFERASE / protein-substrate ternary complexFunction / homology Function and homology informationFunction Domain/homology Component
histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / negative regulation of chromosome condensation / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / Barr body / regulation of centromere complex assembly / histone arginine N-methyltransferase activity / protein methyltransferase activity ... histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / negative regulation of chromosome condensation / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / Barr body / regulation of centromere complex assembly / histone arginine N-methyltransferase activity / protein methyltransferase activity / muscle cell differentiation / regulation of intracellular estrogen receptor signaling pathway / pericentric heterochromatin formation / inner kinetochore / replication fork reversal / protein-arginine N-methyltransferase activity / positive regulation of epithelial cell apoptotic process / oocyte maturation / nucleus organization / histone methyltransferase activity / positive regulation of transcription by RNA polymerase I / nuclear replication fork / spermatid development / subtelomeric heterochromatin formation / single fertilization / positive regulation of fat cell differentiation / RNA polymerase II core promoter sequence-specific DNA binding / Replacement of protamines by nucleosomes in the male pronucleus / nucleosomal DNA binding / response to cAMP / Inhibition of DNA recombination at telomere / RORA activates gene expression / Regulation of lipid metabolism by PPARalpha / telomere organization / embryo implantation / RNA Polymerase I Promoter Opening / Assembly of the ORC complex at the origin of replication / DNA methylation / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / nuclear receptor coactivator activity / PRC2 methylates histones and DNA / Defective pyroptosis / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / lysine-acetylated histone binding / Formation of the beta-catenin:TCF transactivating complex / Heme signaling / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Transcriptional activation of mitochondrial biogenesis / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / multicellular organism growth / B-WICH complex positively regulates rRNA expression / PPARA activates gene expression / Cytoprotection by HMOX1 / Meiotic recombination / Pre-NOTCH Transcription and Translation / RMTs methylate histone arginines / beta-catenin binding / Transcriptional regulation of white adipocyte differentiation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / osteoblast differentiation / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / male gonad development / nucleosome / Circadian Clock / nucleosome assembly / RUNX1 regulates transcription of genes involved in differentiation of HSCs / Factors involved in megakaryocyte development and platelet production / Senescence-Associated Secretory Phenotype (SASP) / positive regulation of cell growth / DNA-binding transcription factor binding / Oxidative Stress Induced Senescence / methylation / Estrogen-dependent gene expression / cell population proliferation / chromosome, telomeric region / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / Amyloid fiber formation / positive regulation of cell population proliferation / regulation of DNA-templated transcription / protein-containing complex / extracellular exosome / extracellular region / nucleoplasm / nucleus / cytosol / cytoplasm Similarity search - Function Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Histone H3 signature 1. / Distorted Sandwich ... Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Histone H3 signature 1. / Distorted Sandwich / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / PH-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.36 Å DetailsAuthors Boriack-Sjodin, P.A. CitationJournal : Acs Chem.Biol. / Year : 2016Title : Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.Authors : Boriack-Sjodin, P.A. / Jin, L. / Jacques, S.L. / Drew, A. / Sneeringer, C. / Scott, M.P. / Moyer, M.P. / Ribich, S. / Moradei, O. / Copeland, R.A. History Deposition Sep 22, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 25, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Mar 30, 2016 Group : Database references
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