登録情報 | データベース: PDB / ID: 5dli |
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タイトル | Corkscrew assembly of SOD1 residues 28-38 |
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要素 | Superoxide dismutase [Cu-Zn] |
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キーワード | UNKNOWN FUNCTION / amyloid-related oligomer |
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機能・相同性 | 機能・相同性情報
action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / retrograde axonal transport / anterograde axonal transport / peripheral nervous system myelin maintenance ...action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / retrograde axonal transport / anterograde axonal transport / peripheral nervous system myelin maintenance / regulation of protein kinase activity / regulation of T cell differentiation in thymus / retina homeostasis / superoxide anion generation / negative regulation of cholesterol biosynthetic process / auditory receptor cell stereocilium organization / hydrogen peroxide biosynthetic process / myeloid cell homeostasis / positive regulation of catalytic activity / muscle cell cellular homeostasis / regulation of GTPase activity / heart contraction / superoxide metabolic process / superoxide dismutase / negative regulation of reproductive process / Detoxification of Reactive Oxygen Species / negative regulation of developmental process / transmission of nerve impulse / superoxide dismutase activity / neuronal action potential / regulation of multicellular organism growth / response to axon injury / ectopic germ cell programmed cell death / ovarian follicle development / positive regulation of phagocytosis / axon cytoplasm / glutathione metabolic process / embryo implantation / : / dendrite cytoplasm / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / removal of superoxide radicals / reactive oxygen species metabolic process / positive regulation of superoxide anion generation / thymus development / regulation of mitochondrial membrane potential / positive regulation of cytokine production / locomotory behavior / determination of adult lifespan / sensory perception of sound / response to hydrogen peroxide / placenta development / mitochondrial intermembrane space / small GTPase binding / regulation of blood pressure / negative regulation of inflammatory response / Platelet degranulation / peroxisome / protein-folding chaperone binding / gene expression / response to heat / cytoplasmic vesicle / spermatogenesis / response to ethanol / intracellular iron ion homeostasis / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / mitochondrial matrix / response to xenobiotic stimulus / positive regulation of apoptotic process / copper ion binding / neuronal cell body / apoptotic process / protein-containing complex / mitochondrion / extracellular space / extracellular exosome / zinc ion binding / extracellular region / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Copper/Zinc superoxide dismutase signature 1. / Superoxide dismutase, copper/zinc, binding site / Copper/Zinc superoxide dismutase signature 2. / Superoxide dismutase, copper/zinc binding domain / Copper/zinc superoxide dismutase (SODC) / Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone / Superoxide dismutase-like, copper/zinc binding domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単一同系置換・異常分散 / 解像度: 2.1 Å |
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Model details | amyloid-related oligomer |
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データ登録者 | Sangwan, S. / Zhao, A. / Sawaya, M.R. / Eisenberg, D. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute on Aging (NIH/NIA) | AG04812 | 米国 |
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引用 | ジャーナル: Proc. Natl. Acad. Sci. U.S.A. / 年: 2017 タイトル: Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). 著者: Sangwan, S. / Zhao, A. / Adams, K.L. / Jayson, C.K. / Sawaya, M.R. / Guenther, E.L. / Pan, A.C. / Ngo, J. / Moore, D.M. / Soriaga, A.B. / Do, T.D. / Goldschmidt, L. / Nelson, R. / Bowers, M.T. ...著者: Sangwan, S. / Zhao, A. / Adams, K.L. / Jayson, C.K. / Sawaya, M.R. / Guenther, E.L. / Pan, A.C. / Ngo, J. / Moore, D.M. / Soriaga, A.B. / Do, T.D. / Goldschmidt, L. / Nelson, R. / Bowers, M.T. / Koehler, C.M. / Shaw, D.E. / Novitch, B.G. / Eisenberg, D.S. |
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履歴 | 登録 | 2015年9月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年9月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月20日 | Group: Author supporting evidence / Derived calculations / カテゴリ: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.2 | 2019年1月9日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.3 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2024年3月6日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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