登録情報 | データベース: PDB / ID: 5dkr |
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タイトル | Crystal Structure of Calcium-loaded S100B bound to SBi29 |
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要素 | Protein S100-B |
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キーワード | METAL BINDING PROTEIN/INHIBITOR / malignant melanoma / calcium binding / complex / covalent inhibitor / METAL BINDING PROTEIN-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
Advanced glycosylation endproduct receptor signaling / TRAF6 mediated NF-kB activation / TAK1-dependent IKK and NF-kappa-B activation / adaptive thermogenesis / kinase inhibitor activity / sympathetic neuron projection extension / positive regulation of complement activation / RAGE receptor binding / negative regulation of monocyte chemotactic protein-1 production / S100 protein binding ...Advanced glycosylation endproduct receptor signaling / TRAF6 mediated NF-kB activation / TAK1-dependent IKK and NF-kappa-B activation / adaptive thermogenesis / kinase inhibitor activity / sympathetic neuron projection extension / positive regulation of complement activation / RAGE receptor binding / negative regulation of monocyte chemotactic protein-1 production / S100 protein binding / astrocyte activation / phosphorylation / axonogenesis / tau protein binding / calcium-dependent protein binding / regulation of translation / positive regulation of canonical NF-kappaB signal transduction / learning or memory / cell adhesion / positive regulation of cell population proliferation / calcium ion binding / protein homodimerization activity / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm類似検索 - 分子機能 Protein S100-B / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / EF hand / EF-hand / Recoverin; domain 1 / EF-hand, calcium binding motif ...Protein S100-B / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / EF hand / EF-hand / Recoverin; domain 1 / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Bos taurus (ウシ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.742 Å |
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データ登録者 | Cavalier, M.C. / Ansari, M.I. / Pierce, A.D. / Wilder, P.T. / McKnight, L.E. / Raman, E.P. / Neau, D.B. / Bezawada, P. / Alasady, M.J. / Varney, K.M. ...Cavalier, M.C. / Ansari, M.I. / Pierce, A.D. / Wilder, P.T. / McKnight, L.E. / Raman, E.P. / Neau, D.B. / Bezawada, P. / Alasady, M.J. / Varney, K.M. / Toth, E.A. / MacKerell Jr., A.D. / Coop, A. / Weber, D.J. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | CA154274 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM58888 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA107331 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2016 タイトル: Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. 著者: Cavalier, M.C. / Ansari, M.I. / Pierce, A.D. / Wilder, P.T. / McKnight, L.E. / Raman, E.P. / Neau, D.B. / Bezawada, P. / Alasady, M.J. / Charpentier, T.H. / Varney, K.M. / Toth, E.A. / ...著者: Cavalier, M.C. / Ansari, M.I. / Pierce, A.D. / Wilder, P.T. / McKnight, L.E. / Raman, E.P. / Neau, D.B. / Bezawada, P. / Alasady, M.J. / Charpentier, T.H. / Varney, K.M. / Toth, E.A. / MacKerell, A.D. / Coop, A. / Weber, D.J. |
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履歴 | 登録 | 2015年9月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年1月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年2月10日 | Group: Database references |
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改定 1.2 | 2017年9月27日 | Group: Author supporting evidence / Database references ...Author supporting evidence / Database references / Derived calculations / Refinement description カテゴリ: citation / pdbx_audit_support ...citation / pdbx_audit_support / pdbx_struct_oper_list / software Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization ..._citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation / _software.classification |
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改定 1.3 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry |
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