登録情報 データベース : PDB / ID : 5db2 構造の表示 ダウンロードとリンクタイトル Menin in complex with MI-389 要素Menin 詳細 キーワード PROTEIN BINDING/INHIBITOR / PROTEIN BINDING / PROTEIN BINDING-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway ... Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / R-SMAD binding / cleavage furrow / MLL1 complex / negative regulation of cell cycle / RHO GTPases activate IQGAPs / negative regulation of osteoblast differentiation / response to UV / four-way junction DNA binding / transcription repressor complex / transcription initiation-coupled chromatin remodeling / negative regulation of protein phosphorylation / Deactivation of the beta-catenin transactivating complex / response to gamma radiation / phosphoprotein binding / Post-translational protein phosphorylation / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Formation of the beta-catenin:TCF transactivating complex / negative regulation of DNA-binding transcription factor activity / nuclear matrix / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / MAPK cascade / protein-macromolecule adaptor activity / double-stranded DNA binding / chromosome, telomeric region / transcription cis-regulatory region binding / negative regulation of cell population proliferation / endoplasmic reticulum lumen / DNA repair / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytosol / cytoplasm 類似検索 - 分子機能生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.54 Å 詳細データ登録者 Pollock, J. / Dmitry, B. / Cierpicki, T. / Grembecka, J. 資金援助 米国, 7件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) 1R01CA160467 米国 Leukemia & Lymphoma Society 6116-12 米国 Leukemia & Lymphoma Society 1215-14 米国 Leukemia & Lymphoma Society Therapy Acceleration Program 米国 American Chemical Society RSG-11-082-01-DMC 米国 American Chemical Society RSG-13-130-01-CDD 米国 APS LSCAT 085P1000817 米国
引用ジャーナル : J.Med.Chem. / 年 : 2016タイトル : Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).著者 : Borkin, D. / Pollock, J. / Kempinska, K. / Purohit, T. / Li, X. / Wen, B. / Zhao, T. / Miao, H. / Shukla, S. / He, M. / Sun, D. / Cierpicki, T. / Grembecka, J. 履歴 登録 2015年8月20日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年3月30日 Provider : repository / タイプ : Initial release改定 1.1 2017年9月27日 Group : Author supporting evidence / Database references / Derived calculationsカテゴリ : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation改定 1.2 2019年12月4日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.3 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_initial_refinement_model Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name
すべて表示 表示を減らす