登録情報 | データベース: PDB / ID: 5d9y |
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タイトル | Crystal structure of TET2-5fC complex |
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要素 | - DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3')
- DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3')
- Methylcytosine dioxygenase TET2,Methylcytosine dioxygenase TET2
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キーワード | oxidoreductase/DNA / 5-methylcytosine dioxygenase / TET2 / 5-formylcytosine / protein-DNA complex / oxidoreductase-DNA complex |
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機能・相同性 | 機能・相同性情報
leukocyte differentiation / methylcytosine dioxygenase / 5-methylcytosine catabolic process / 5-methylcytosine dioxygenase activity / TET1,2,3 and TDG demethylate DNA / Specification of primordial germ cells / : / positive regulation of gene expression via chromosomal CpG island demethylation / myeloid cell differentiation / protein O-linked glycosylation ...leukocyte differentiation / methylcytosine dioxygenase / 5-methylcytosine catabolic process / 5-methylcytosine dioxygenase activity / TET1,2,3 and TDG demethylate DNA / Specification of primordial germ cells / : / positive regulation of gene expression via chromosomal CpG island demethylation / myeloid cell differentiation / protein O-linked glycosylation / ferrous iron binding / response to organic cyclic compound / chromosome / cell cycle / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 : / Methylcytosine dioxygenase TET1/2/3 / Oxygenase domain of the 2OGFeDO superfamily / 2OGFeDO, oxygenase domain / Oxygenase domain of the 2OGFeDO superfamily 類似検索 - ドメイン・相同性 : / N-OXALYLGLYCINE / DNA / DNA (> 10) / Methylcytosine dioxygenase TET2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.971 Å |
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データ登録者 | Hu, L. / Cheng, J. / Rao, Q. / Li, Z. / Li, J. / Xu, Y. |
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引用 | ジャーナル: Nature / 年: 2015 タイトル: Structural insight into substrate preference for TET-mediated oxidation. 著者: Hu, L. / Lu, J. / Cheng, J. / Rao, Q. / Li, Z. / Hou, H. / Lou, Z. / Zhang, L. / Li, W. / Gong, W. / Liu, M. / Sun, C. / Yin, X. / Li, J. / Tan, X. / Wang, P. / Wang, Y. / Fang, D. / Cui, Q. ...著者: Hu, L. / Lu, J. / Cheng, J. / Rao, Q. / Li, Z. / Hou, H. / Lou, Z. / Zhang, L. / Li, W. / Gong, W. / Liu, M. / Sun, C. / Yin, X. / Li, J. / Tan, X. / Wang, P. / Wang, Y. / Fang, D. / Cui, Q. / Yang, P. / He, C. / Jiang, H. / Luo, C. / Xu, Y. |
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履歴 | 登録 | 2015年8月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年11月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年11月18日 | Group: Database references / Other |
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改定 1.2 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model / pdbx_struct_oper_list / struct_conn / struct_conn_type Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id |
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