Entry Database : PDB / ID : 5csf Structure visualization Downloads & linksTitle S100B-RSK1 crystal structure A ComponentsProtein S100-B Ribosomal protein S6 kinase alpha-1 DetailsKeywords TRANSFERASE / Complex / Kinase / Signaling / InhibitorFunction / homology Function and homology informationFunction Domain/homology Component
regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / adaptive thermogenesis / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / sympathetic neuron projection extension / RAGE receptor binding / Gastrin-CREB signalling pathway via PKC and MAPK ... regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / adaptive thermogenesis / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / sympathetic neuron projection extension / RAGE receptor binding / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / negative regulation of TOR signaling / S100 protein binding / ERK/MAPK targets / regulation of neuronal synaptic plasticity / Recycling pathway of L1 / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / TRAF6 mediated NF-kB activation / Advanced glycosylation endproduct receptor signaling / Transcriptional and post-translational regulation of MITF-M expression and activity / Nuclear signaling by ERBB4 / ruffle / protein serine/threonine/tyrosine kinase activity / positive regulation of neuron differentiation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / axonogenesis / central nervous system development / positive regulation of cell differentiation / TAK1-dependent IKK and NF-kappa-B activation / tau protein binding / memory / calcium-dependent protein binding / Senescence-Associated Secretory Phenotype (SASP) / positive regulation of cell growth / chemical synaptic transmission / positive regulation of canonical NF-kappaB signal transduction / learning or memory / non-specific serine/threonine protein kinase / cell adhesion / intracellular signal transduction / protein phosphorylation / intracellular membrane-bounded organelle / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / synapse / calcium ion binding / positive regulation of cell population proliferation / negative regulation of apoptotic process / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription / magnesium ion binding / signal transduction / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space / zinc ion binding / extracellular region / nucleoplasm / ATP binding / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function Ribosomal S6 kinase, N-terminal catalytic domain / Protein S100-B / Ribosomal protein S6 kinase II / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / Protein kinase, C-terminal / Protein kinase C terminal domain ... Ribosomal S6 kinase, N-terminal catalytic domain / Protein S100-B / Ribosomal protein S6 kinase II / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / Protein kinase, C-terminal / Protein kinase C terminal domain / EF hand / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / EF-hand / Recoverin; domain 1 / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.4 Å DetailsAuthors Gogl, G. / Nyitray, L. CitationJournal : J.Biol.Chem. / Year : 2016Title : Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.Authors : Gogl, G. / Alexa, A. / Kiss, B. / Katona, G. / Kovacs, M. / Bodor, A. / Remenyi, A. / Nyitray, L. History Deposition Jul 23, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Nov 11, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Nov 18, 2015 Group : Database referencesRevision 1.2 Jan 13, 2016 Group : Database referencesRevision 1.3 May 8, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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