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- PDB-5cmn: FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 5cmn
TitleFLRT3 LRR domain in complex with LPHN3 Olfactomedin domain
Components
  • Latrophilin-3
  • Leucine-rich repeat transmembrane protein FLRT3
KeywordsCell Adhesion/Carbohydrate Binding / LRR repeats / Cell Adhesion-Carbohydrate Binding complex / ADGRL3
Function / homology
Function and homology information


proepicardium cell migration involved in pericardium morphogenesis / head development / growth cone membrane / synaptic membrane adhesion / cell-cell adhesion via plasma-membrane adhesion molecules / embryonic morphogenesis / Signaling by ROBO receptors / fibroblast growth factor receptor binding / Downstream signaling of activated FGFR1 / chemorepellent activity ...proepicardium cell migration involved in pericardium morphogenesis / head development / growth cone membrane / synaptic membrane adhesion / cell-cell adhesion via plasma-membrane adhesion molecules / embryonic morphogenesis / Signaling by ROBO receptors / fibroblast growth factor receptor binding / Downstream signaling of activated FGFR1 / chemorepellent activity / positive regulation of synapse assembly / neuron projection extension / fibroblast growth factor receptor signaling pathway / response to axon injury / axonal growth cone / axon terminus / synapse assembly / extracellular matrix / axon guidance / synaptic membrane / G protein-coupled receptor activity / neuron migration / adenylate cyclase-activating G protein-coupled receptor signaling pathway / neuron projection development / cell-cell junction / cell junction / heart development / protein-macromolecule adaptor activity / carbohydrate binding / postsynaptic membrane / postsynaptic density / cell surface receptor signaling pathway / G protein-coupled receptor signaling pathway / axon / focal adhesion / glutamatergic synapse / calcium ion binding / endoplasmic reticulum membrane / protein homodimerization activity / extracellular space / membrane / plasma membrane / cytosol
Similarity search - Function
: / GPCR, family 2, latrophilin, C-terminal / GPCR, family 2, latrophilin / Latrophilin Cytoplasmic C-terminal region / D-galactoside/L-rhamnose binding SUEL lectin domain superfamily / GAIN domain, N-terminal / GPCR-Autoproteolysis INducing (GAIN) domain / D-galactoside/L-rhamnose binding SUEL lectin domain / Galactose binding lectin domain / SUEL-type lectin domain profile. ...: / GPCR, family 2, latrophilin, C-terminal / GPCR, family 2, latrophilin / Latrophilin Cytoplasmic C-terminal region / D-galactoside/L-rhamnose binding SUEL lectin domain superfamily / GAIN domain, N-terminal / GPCR-Autoproteolysis INducing (GAIN) domain / D-galactoside/L-rhamnose binding SUEL lectin domain / Galactose binding lectin domain / SUEL-type lectin domain profile. / Olfactomedin-like domain / Olfactomedin-like domain / Olfactomedin-like domain profile. / Olfactomedin-like domains / GAIN domain superfamily / GPCR proteolysis site, GPS, motif / GPS motif / GAIN-B domain profile. / G-protein-coupled receptor proteolytic site domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / Hormone receptor domain / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / Alpha-Beta Horseshoe / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Leucine-rich repeat domain superfamily / Immunoglobulin-like fold / Alpha Beta
Similarity search - Domain/homology
Adhesion G protein-coupled receptor L3 / Leucine-rich repeat transmembrane protein FLRT3
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.605 Å
AuthorsLu, Y. / Salzman, G. / Arac, D.
CitationJournal: Structure / Year: 2015
Title: Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Authors: Lu, Y.C. / Nazarko, O.V. / Sando, R. / Salzman, G.S. / Sudhof, T.C. / Arac, D.
History
DepositionJul 17, 2015Deposition site: RCSB / Processing site: RCSB
Revision 1.0Aug 12, 2015Provider: repository / Type: Initial release
Revision 1.1Sep 16, 2015Group: Database references
Revision 1.2Jul 29, 2020Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
Category: chem_comp / citation ...chem_comp / citation / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_oper_list / struct_conn / struct_site / struct_site_gen
Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _citation.journal_id_CSD / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_role
Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 1.3Sep 27, 2023Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary
Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.4Oct 16, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Leucine-rich repeat transmembrane protein FLRT3
B: Leucine-rich repeat transmembrane protein FLRT3
C: Leucine-rich repeat transmembrane protein FLRT3
D: Leucine-rich repeat transmembrane protein FLRT3
E: Latrophilin-3
F: Latrophilin-3
G: Latrophilin-3
H: Latrophilin-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)272,93116
Polymers271,8868
Non-polymers1,0458
Water00
1
A: Leucine-rich repeat transmembrane protein FLRT3
E: Latrophilin-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)68,2334
Polymers67,9722
Non-polymers2612
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: Leucine-rich repeat transmembrane protein FLRT3
F: Latrophilin-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)68,2334
Polymers67,9722
Non-polymers2612
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
C: Leucine-rich repeat transmembrane protein FLRT3
G: Latrophilin-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)68,2334
Polymers67,9722
Non-polymers2612
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
D: Leucine-rich repeat transmembrane protein FLRT3
H: Latrophilin-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)68,2334
Polymers67,9722
Non-polymers2612
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)102.268, 102.268, 419.230
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number78
Space group name H-MP43

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Components

#1: Protein
Leucine-rich repeat transmembrane protein FLRT3 / Fibronectin-like domain-containing leucine-rich transmembrane protein 3


Mass: 37962.219 Da / Num. of mol.: 4 / Fragment: UNP residues 29-357
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FLRT3, KIAA1469, UNQ856/PRO1865 / Production host: Trichoplusia ni (cabbage looper) / References: UniProt: Q9NZU0
#2: Protein
Latrophilin-3 / Calcium-independent alpha-latrotoxin receptor 3 / CIRL-3 / Lectomedin-3


Mass: 30009.295 Da / Num. of mol.: 4 / Fragment: UNP residues 132-392
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: LPHN3, KIAA0768, LEC3 / Production host: Trichoplusia ni (cabbage looper) / References: UniProt: Q9HAR2
#3: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#4: Chemical
ChemComp-CA / CALCIUM ION


Mass: 40.078 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Ca
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION

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Sample preparation

CrystalDensity Matthews: 4.03 Å3/Da / Density % sol: 69.49 %
Crystal growTemperature: 295 K / Method: evaporation / pH: 6
Details: 10% (w/v) PEG 3000, 100mM MES pH6.0, 200mM Lithium sulfate

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Data collection

DiffractionMean temperature: 295 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 19-BM / Wavelength: 1.00883 Å
DetectorType: ADSC QUANTUM 210r / Detector: CCD / Date: Dec 12, 2014
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.00883 Å / Relative weight: 1
ReflectionResolution: 3.6→75 Å / Num. obs: 45263 / % possible obs: 92 % / Redundancy: 3.6 % / Rmerge(I) obs: 0.229 / Net I/σ(I): 6.031
Reflection shellResolution: 3.6→3.66 Å / Redundancy: 1.7 % / Rmerge(I) obs: 0.568 / Mean I/σ(I) obs: 1.347 / % possible all: 60.6

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Processing

Software
NameVersionClassification
PHENIX1.9_1692refinement
Cootmodel building
HKL-2000data scaling
HKL-2000data reduction
PHENIXphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4WXQ

4wxq


Resolution: 3.605→73.196 Å / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 42.79 / Stereochemistry target values: TWIN_LSQ_F
RfactorNum. reflection% reflection
Rfree0.2618 1979 4.37 %
Rwork0.195 --
obs0.1987 45263 91.74 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 3.605→73.196 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms18360 0 60 0 18420
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00518888
X-RAY DIFFRACTIONf_angle_d0.93825664
X-RAY DIFFRACTIONf_dihedral_angle_d12.8126960
X-RAY DIFFRACTIONf_chiral_restr0.0372852
X-RAY DIFFRACTIONf_plane_restr0.0043316
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.6087-3.70630.34381050.24892303X-RAY DIFFRACTION61
3.7063-3.81530.28181250.23292915X-RAY DIFFRACTION77
3.8153-3.93840.30051390.23243246X-RAY DIFFRACTION86
3.9384-4.07920.27641420.21873367X-RAY DIFFRACTION89
4.0792-4.24250.28141400.21283426X-RAY DIFFRACTION91
4.2425-4.43550.25451500.1953461X-RAY DIFFRACTION92
4.4355-4.66920.26041530.18873482X-RAY DIFFRACTION92
4.6692-4.96160.26191410.17733482X-RAY DIFFRACTION93
4.9616-5.34450.24321500.18093528X-RAY DIFFRACTION94
5.3445-5.88190.26861510.19913531X-RAY DIFFRACTION94
5.8819-6.7320.29221490.18993569X-RAY DIFFRACTION94
6.732-8.47780.24581520.19043529X-RAY DIFFRACTION93
8.4778-59.52930.23351520.17473549X-RAY DIFFRACTION94
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.1365-1.42641.80351.8025-2.25332.8522-0.0071-0.19530.07470.33830.03410.2549-0.3081-0.6282-0.07891.2432-0.1937-0.14470.8461-0.13220.795842.21654.625642.5498
20.63070.14520.43031.28590.09540.2968-0.2603-0.17780.03110.5792-0.13040.3212-0.1079-0.17930.04771.41290.00950.06930.1866-0.05860.645949.974865.171643.9592
30.5543-0.0776-0.24781.50530.5191.14-0.0338-0.13-0.15510.5906-0.065-0.558-0.14050.0855-0.13721.29280.0198-0.17620.0299-0.14740.692764.18871.535143.9799
40.2592-0.22260.70510.1976-0.61271.92740.1251-0.7230.11770.3825-0.0301-0.2081-0.54480.2628-0.05430.8898-0.0775-0.24140.6815-0.10550.746877.187374.296739.6693
50.11870.09070.08510.495-0.3580.8835-0.2451-0.2479-0.24340.3447-0.149-0.6027-0.27710.38020.22490.5377-0.3031-0.18311.49410.09651.21986.428868.858932.6224
61.89090.0295-0.95390.5858-0.43821.3737-0.01390.1432-0.1329-0.022-0.2306-0.5252-0.04410.50660.17490.6848-0.015-0.06321.7199-0.36381.3895.287462.604522.7313
70.0345-0.0130.0090.0148-0.01760.0155-0.17430.07510.43180.13590.12990.4702-0.593-0.47610.04551.52210.26950.04132.16780.10471.80698.77564.891910.4554
80.4562-0.37210.16091.3251-0.25610.4357-0.0769-0.02320.2475-0.0915-0.13590.4007-0.2631-0.3888-0.01751.34880.3536-0.1818-0.0385-0.19590.851139.47488.673531.61
90.6023-0.1544-0.35421.2370.51780.5354-0.09050.255-0.2741-0.3479-0.31940.2957-0.288-0.2327-0.00851.4404-0.1018-0.17480.0481-0.05030.774652.346580.319315.2321
100.60490.1517-0.05091.2803-0.64892.35680.00080.3646-0.0592-0.1132-0.3511-0.0844-0.46110.40440.30771.2698-0.2948-0.06520.63460.02750.656672.298683.00457.0306
110.8564-0.5260.43510.538-0.3440.2458-0.09450.4170.35-0.264-0.0865-0.4765-0.13870.4382-0.01331.6701-0.88310.00071.5678-0.22151.011389.132587.9169.041
120.09940.28250.37811.15120.19314.10060.11550.38220.3035-0.2980.0244-0.3874-0.31050.1888-0.10321.0764-0.0332-0.0220.90670.16860.821563.377477.1691-33.8245
131.0294-0.07051.82432.1676-0.35263.24940.22160.97780.0887-0.0699-0.0603-0.23480.1182-0.193-0.07780.54510.2631-0.02640.8660.01790.609151.981865.7043-35.6704
141.4047-0.6261-1.92060.78780.44523.25820.12620.6702-0.185-0.13320.12760.03520.1438-0.1934-0.16820.79310.1993-0.25230.6248-0.20480.873150.072254.3954-32.7968
150.3470.6306-0.17572.39161.60163.26-0.04940.318-0.291-0.3959-0.01460.21570.4318-0.33590.18491.32190.0233-0.46730.3305-0.21810.98847.421444.6842-29.8695
160.1122-0.0239-0.15270.07150.16881.143-0.06930.6006-0.4972-0.4866-0.0632-0.00430.1198-0.29570.08391.39410.0393-0.29430.4908-0.4360.777551.066841.178-26.4526
171.29960.85991.46513.87441.73261.846-0.20590.5061-0.67710.072-0.183-0.01380.386-0.21460.23351.374-0.12380.01450.9464-0.29151.144453.114534.3056-24.456
180.7554-0.6305-0.46521.2841.27931.4548-0.3570.2431-0.3433-0.3482-0.0174-0.23120.1746-0.14380.18451.98750.2826-0.30810.635-0.44911.389355.898330.7865-15.6277
190.03650.02140.08090.0180.0630.1827-0.1347-0.02120.0743-0.0505-0.2815-0.123-0.06320.08740.12722.27330.0035-0.55970.412-0.05641.852959.192623.6014-8.1138
204.10220.9092-1.65490.4868-0.74651.18210.2288-0.03040.6529-0.05490.0910.1891-0.4996-0.2476-0.23740.93950.3932-0.07631.6057-0.09250.910227.275684.8767-27.0886
210.6464-0.4645-0.11330.47530.30050.36270.1365-0.26370.36820.09220.05440.1544-0.5261-0.3991-0.24651.33260.2339-0.14870.4810.02750.858634.177382.8115-21.3742
220.47020.23710.12910.38020.68471.6401-0.2526-0.19170.41020.08950.0091-0.2355-0.4387-0.49840.08040.85090.0923-0.03970.1435-0.24260.906539.564177.0356-11.0857
232.5564-2.5323-0.69783.8156-0.66981.6427-0.031-0.20080.03940.19730.2104-0.3129-0.0140.1625-0.13460.48860.0033-0.09190.286-0.19110.69243.109965.9983-4.3889
240.3117-0.3894-0.12381.4236-0.34771.2452-0.0714-0.72230.03770.3721-0.1487-0.04130.2149-0.35010.20370.962-0.1472-0.12890.5473-0.16320.700240.049754.71591.9791
251.16010.61540.19570.5509-0.34720.9699-0.0417-0.5394-0.63920.25210.15590.26420.2028-0.381-0.00422.1395-0.48270.01550.76480.20310.897134.827834.88450.8345
260.81070.48270.17690.32810.15890.1130.0279-0.1759-0.13340.3239-0.1081-0.25070.1101-0.00280.04681.6590.2805-0.18810.48380.08930.983564.077327.027822.2912
270.2085-0.04680.96040.2948-0.19314.35070.26650.1821-0.1799-0.10850.1578-0.43260.41240.5064-0.36381.59570.269-0.34210.4022-0.25230.679773.028941.700923.0029
280.14260.19030.03870.365-0.28450.9790.01020.0644-0.3137-0.163-0.0667-0.28450.26360.3652-0.1561.57610.1016-0.23590.4047-0.21231.166275.794448.477823.9125
291.55160.0959-0.85072.99560.19831.08670.0842-0.03440.05720.0616-0.0973-0.00420.10180.105-0.02491.0886-0.1168-0.2443-0.08090.09920.971863.632953.806719.8195
300.14830.1336-0.08150.3167-0.12790.04660.1122-0.0624-0.10360.1832-0.0918-0.13620.1983-0.1894-0.03221.4386-0.40620.0062-0.420.11850.583152.48246.708424.1416
310.39190.3140.40950.320.43510.59850.08180.0589-0.11030.1401-0.00420.09070.0651-0.04130.05931.6427-0.4159-0.2771-0.2970.04111.226251.628632.325625.4648
321.57760.51180.15612.20290.58510.15660.196-0.3929-0.12840.2519-0.1226-0.11370.2484-0.12090.00681.5359-0.2038-0.35020.54630.13160.714964.975134.069127.648
331.28810.64240.48942.31970.44410.46860.04580.0518-0.1151-0.0626-0.06120.24750.1319-0.03660.0331.96090.0848-0.34470.3189-0.01610.804968.888833.97627.6474
340.53350.63410.15750.84720.25030.07440.09910.08790.0108-0.1716-0.0579-0.1437-0.1170.1633-0.08861.7873-0.1165-0.4806-0.04440.00091.163369.6375108.456130.4996
350.4720.6103-0.1741.2994-0.54920.57970.05930.05680.1299-0.13880.0619-0.3354-0.24070.10690.03751.7012-0.1191-0.26740.17530.05920.918972.8522100.507730.4086
360.5351-0.4276-0.20180.77140.16590.2631-0.06790.0694-0.10040.092-0.1938-0.0261-0.201-0.1151-0.12991.6481-0.00180.0013-0.0109-0.20490.709563.640392.47137.9828
370.1680.0237-0.05670.38640.31060.30050.0973-0.0872-0.0367-0.07740.04070.2323-0.06730.04130.10082.10440.063-0.30350.0244-0.29861.100757.8004102.859143.9058
380.27340.2365-0.17390.2854-0.18170.128-0.0508-0.1659-0.01730.18370.0337-0.03570.12730.0623-0.00952.39530.256-0.34710.554-0.19350.999856.8728114.289745.0776
390.6358-0.2273-0.66691.68870.61541.01910.23990.29060.2985-0.7996-0.215-0.0319-0.4525-0.2814-0.00441.8050.3064-0.07110.3068-0.09030.920662.2019116.347835.0794
401.52070.61920.02671.5410.06670.23690.1509-0.0240.216-0.15590.1612-0.0148-0.15920.2363-0.16031.9724-0.3434-0.49080.6079-0.07270.939866.2375116.009430.9329
410.99240.7960.55330.71330.7161.3315-0.1560.4708-0.65860.1686-0.0135-0.29490.6637-0.21630.09790.5581-0.0521-0.19731.5864-0.28551.170894.71157.6799-12.8102
420.04020.03560.08350.1642-0.10870.45880.0389-0.0699-0.33820.08020.09290.02590.3270.2137-0.16110.50770.5373-0.26371.6115-0.16420.697176.564747.9219-14.649
432.7914-1.2363-0.35051.18170.29290.274-0.00650.12610.1003-0.3513-0.1735-0.4110.10220.18480.06940.80520.43120.0920.7527-0.3750.818469.111449.6402-13.6614
440.4038-0.0366-0.26060.23090.06980.27820.13630.13930.06460.10610.32060.07080.05890.585-0.16130.199-0.16070.03691.1622-0.05560.623471.248163.1423-12.7333
451.125-0.4696-0.84520.61480.41371.89770.3281-0.29660.36670.17270.076-0.3007-0.20630.4923-0.23890.316-0.22220.14221.95320.10910.885182.34771.6935-14.8303
460.1172-0.11810.15830.1904-0.09710.2834-0.08140.05320.1417-0.02510.1554-0.2479-0.08010.3672-0.09010.59930.10240.18072.2552-0.08750.684988.257556.0733-18.5612
470.79340.091-0.41180.79510.10670.80060.27580.1381-0.3898-0.12920.11720.412-0.0031-0.1351-0.05570.25710.0814-0.0432.0902-0.14071.14228.524251.3478-23.9361
480.98611.2981-0.13782.371-0.54990.27210.00150.0365-0.3856-0.16950.19680.11430.1913-0.2193-0.07810.2083-0.42750.04961.4265-0.29341.147121.342450.4867-17.2982
491.0411-0.8099-0.66723.1335-0.00630.85210.10020.2280.1229-0.0608-0.09570.0130.1675-0.0743-0.02340.11110.0280.03541.4735-0.08690.736727.832356.9759-28.7666
505.35230.99551.06731.215-0.50510.8179-0.03530.0256-0.1047-0.00850.0531-0-0.0153-0.35260.05310.0701-0.0403-0.09181.4577-0.25290.718217.398962.458-30.2012
512.0889-0.9197-1.16330.97950.38150.6954-0.01840.3566-0.0163-0.1537-0.0727-0.28110.0087-0.17070.00350.15840.1213-0.03961.8655-0.15070.794716.640465.2806-35.9723
524.38350.1369-1.64990.9576-0.3080.69370.09890.16140.2146-0.0932-0.0253-0.0222-0.06650.1141-0.07080.26420.1056-0.02841.9361-0.25570.78346.512667.4603-38.008
530.24460.0759-0.48090.0167-0.13620.94620.2056-0.16850.0320.02850.32360.0748-0.2367-0.2614-0.34890.40390.02070.13332.1449-0.05031.10645.661759.7014-25.7604
540.58170.4101-0.52463.54492.88363.9815-0.0950.05580.11550.00560.20630.114-0.1245-0.31720.00370.6706-0.15290.25552.2861-0.0290.73995.997455.3578-21.6285
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND RESID 30:64 )A30 - 64
2X-RAY DIFFRACTION2( CHAIN A AND RESID 65:120 )A65 - 120
3X-RAY DIFFRACTION3( CHAIN A AND RESID 121:191 )A121 - 191
4X-RAY DIFFRACTION4( CHAIN A AND RESID 192:220 )A192 - 220
5X-RAY DIFFRACTION5( CHAIN A AND RESID 221:292 )A221 - 292
6X-RAY DIFFRACTION6( CHAIN A AND RESID 293:335 )A293 - 335
7X-RAY DIFFRACTION7( CHAIN A AND RESID 336:350 )A336 - 350
8X-RAY DIFFRACTION8( CHAIN B AND RESID 30:120 )B30 - 120
9X-RAY DIFFRACTION9( CHAIN B AND RESID 121:215 )B121 - 215
10X-RAY DIFFRACTION10( CHAIN B AND RESID 216:292 )B216 - 292
11X-RAY DIFFRACTION11( CHAIN B AND RESID 293:350 )B293 - 350
12X-RAY DIFFRACTION12( CHAIN C AND RESID 30:94 )C30 - 94
13X-RAY DIFFRACTION13( CHAIN C AND RESID 95:148 )C95 - 148
14X-RAY DIFFRACTION14( CHAIN C AND RESID 149:191 )C149 - 191
15X-RAY DIFFRACTION15( CHAIN C AND RESID 192:220 )C192 - 220
16X-RAY DIFFRACTION16( CHAIN C AND RESID 221:241 )C221 - 241
17X-RAY DIFFRACTION17( CHAIN C AND RESID 242:273 )C242 - 273
18X-RAY DIFFRACTION18( CHAIN C AND RESID 274:310 )C274 - 310
19X-RAY DIFFRACTION19( CHAIN C AND RESID 311:350 )C311 - 350
20X-RAY DIFFRACTION20( CHAIN D AND RESID 30:64 )D30 - 64
21X-RAY DIFFRACTION21( CHAIN D AND RESID 65:94 )D65 - 94
22X-RAY DIFFRACTION22( CHAIN D AND RESID 95:165 )D95 - 165
23X-RAY DIFFRACTION23( CHAIN D AND RESID 166:191 )D166 - 191
24X-RAY DIFFRACTION24( CHAIN D AND RESID 192:273 )D192 - 273
25X-RAY DIFFRACTION25( CHAIN D AND RESID 274:350 )D274 - 350
26X-RAY DIFFRACTION26( CHAIN E AND RESID 134:147 )E134 - 147
27X-RAY DIFFRACTION27( CHAIN E AND RESID 148:168 )E148 - 168
28X-RAY DIFFRACTION28( CHAIN E AND RESID 169:201 )E169 - 201
29X-RAY DIFFRACTION29( CHAIN E AND RESID 202:236 )E202 - 236
30X-RAY DIFFRACTION30( CHAIN E AND RESID 237:311 )E237 - 311
31X-RAY DIFFRACTION31( CHAIN E AND RESID 312:354 )E312 - 354
32X-RAY DIFFRACTION32( CHAIN E AND RESID 355:374 )E355 - 374
33X-RAY DIFFRACTION33( CHAIN E AND RESID 375:391 )E375 - 391
34X-RAY DIFFRACTION34( CHAIN F AND RESID 134:185 )F134 - 185
35X-RAY DIFFRACTION35( CHAIN F AND RESID 186:221 )F186 - 221
36X-RAY DIFFRACTION36( CHAIN F AND RESID 222:253 )F222 - 253
37X-RAY DIFFRACTION37( CHAIN F AND RESID 254:309 )F254 - 309
38X-RAY DIFFRACTION38( CHAIN F AND RESID 310:351 )F310 - 351
39X-RAY DIFFRACTION39( CHAIN F AND RESID 352:374 )F352 - 374
40X-RAY DIFFRACTION40( CHAIN F AND RESID 375:391 )F375 - 391
41X-RAY DIFFRACTION41( CHAIN G AND RESID 134:147 )G134 - 147
42X-RAY DIFFRACTION42( CHAIN G AND RESID 148:192 )G148 - 192
43X-RAY DIFFRACTION43( CHAIN G AND RESID 193:211 )G193 - 211
44X-RAY DIFFRACTION44( CHAIN G AND RESID 212:277 )G212 - 277
45X-RAY DIFFRACTION45( CHAIN G AND RESID 278:351 )G278 - 351
46X-RAY DIFFRACTION46( CHAIN G AND RESID 352:391 )G352 - 391
47X-RAY DIFFRACTION47( CHAIN H AND RESID 134:168 )H134 - 168
48X-RAY DIFFRACTION48( CHAIN H AND RESID 169:211 )H169 - 211
49X-RAY DIFFRACTION49( CHAIN H AND RESID 212:253 )H212 - 253
50X-RAY DIFFRACTION50( CHAIN H AND RESID 254:277 )H254 - 277
51X-RAY DIFFRACTION51( CHAIN H AND RESID 278:324 )H278 - 324
52X-RAY DIFFRACTION52( CHAIN H AND RESID 325:351 )H325 - 351
53X-RAY DIFFRACTION53( CHAIN H AND RESID 352:374 )H352 - 374
54X-RAY DIFFRACTION54( CHAIN H AND RESID 375:391 )H375 - 391

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